Results 271 to 280 of about 2,825,424 (355)

Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.

Journal of Pharmacology and Experimental Therapeutics, 2000
STI571 (formerly known as CGP 57148B) is a protein-tyrosine kinase inhibitor that is currently in clinical trials for the treatment of chronic myelogenous leukemia.
E. Buchdunger, C. Cioffi, N. M. Law, D. Stover, Sayuri Ohno-Jones, B. Druker, N. Lydon   +6 more
semanticscholar   +1 more source

Keratinocyte Growth Factor Receptors

Dermatologic Clinics, 2007
Modulation of the number of functional growth factor receptors on the epithelial cell surface that is exposed to the action of cognate ligands represents a key strategy in cellular physiology to regulate the proliferation rate and the differentiation process. The keratinocyte growth factor receptor (KGFR) and the epidermal growth factor receptor (EGFR),
Vincenzo de Giorgi, Serena Sestini, MASSI, DANIELA, Ilaria Ghersetich, LOTTI, TORELLO   +4 more
openaire   +3 more sources

Epidermal growth factor receptors

Molecular and Cellular Biochemistry, 1981
EGF-Rs are cell membrane glycoproteins of wide distribution. They have not yet been fully characterized or purified but are probably molecules of 170-190,000 mol. wt. in most cells. The growth factor EGF binds and will saturate cell surface receptors with a KA of about 5 X 10(9) M-1 although a receptor class with an affinity in excess of 10(10) M-1 has
E D, Adamson, A R, Rees
openaire   +2 more sources

Growth factor receptors and their ligands

Journal of Neuro-Oncology, 1994
The understanding of the signal transduction cascade involving growth factors and their receptors is one major key for diagnostic and therapeutic improvements in human neoplasms. Using receptor autoradiography, an inverse relationship for the incidence of somatostatin receptors (SSR) and epidermal growth factor receptors (EGFR) was found in gliomas [1].
Eppenberger U, Mueller H
openaire   +3 more sources

Endocytosis of growth factor receptors

BioEssays, 1993
AbstractBinding of a growth factor (GF) to its specific receptor on the cell surface causes the initiation of a signal transduction cascade which eventually results in mitosis. GF:receptor complexes are removed from the cell surface via receptor‐mediated endocytosis, a process which involves clathrin‐coated pits.
A, Sorkin, C M, Waters
openaire   +2 more sources

Growth factor receptors

British Medical Bulletin, 1989
The initial interaction of growth factors with their target cells is mediated by specific high affinity cell surface receptors. The structural and functional diversity found in growth factors is more limited at the receptor level where receptors for structurally and functionally distinct factors seem to share structural motifs and employ a restricted ...
openaire   +2 more sources

Hematopoietic growth factor receptors

The International Journal of Cell Cloning, 1991
The molecular cloning for most of the hematopoietic growth factor receptors has been achieved over the past few years and revealed that they can by assigned to two discrete receptor families, namely the hematopoietic growth factor superfamily (HRS) and the receptor tyrosine kinase family (RTK).
M F, Brizzi, G C, Avanzi, L, Pegoraro
openaire   +2 more sources

Growth factor receptors and medulloblastoma

Journal of Neuro-Oncology, 1996
Growth factors and their receptors play important roles in the regulation of cell division, development and differentiation. Neurotrophins are growth factors which have not been shown, until recently, to be associated with human neoplasia. Medulloblastoma is a central nervous system tumor which is thought to arise from the external granule cell layer ...
openaire   +2 more sources

Receptors for Nerve Growth Factor

1993
Publisher Summary This chapter discusses the two receptors for nerve growth factor (NGF)—namely, (1) the low-affinity NGF receptor and (2) the product of the proto-oncogene trk . It also reviews the way they were originally identified and the structural and functional features of the two receptors.
M V, Chao, D S, Battleman, M, Benedetti
openaire   +2 more sources

Fibroblast growth factors and their receptors

Biochemistry and Cell Biology, 1997
Fibroblast growth factors (FGFs) represent a group of polypeptide mitogens eliciting a wide variety of responses depending upon the target cell type. The knowledge of the cell surface receptors mediating the effects of FGFs has recently expanded remarkably.
Z, Galzie, A R, Kinsella, J A, Smith
openaire   +2 more sources