Results 281 to 290 of about 2,825,424 (355)
Some of the next articles are maybe not open access.
Growth factors, receptors and cancer
BioEssays, 1986AbstractIt now appears that the molecular events associated with the mitogenic action of growth factors are also the events perturbed in neoplastic lesions. This review outlines the relevance of our recent progress in the biochemistry of growth factors and their receptors to the induction and maintenance of the neoplastic state.
openaire +2 more sources
1991
Proliferation of normal cells is regulated through the complex interaction of each cell with neighboring homologous and heterologous cells and extracellular tissue components forming its microenvironment. In addition to the cell-cell and cell-extracellular matrix contact, the proliferation of cells is regulated by a variety of soluble growth factors ...
openaire +2 more sources
Proliferation of normal cells is regulated through the complex interaction of each cell with neighboring homologous and heterologous cells and extracellular tissue components forming its microenvironment. In addition to the cell-cell and cell-extracellular matrix contact, the proliferation of cells is regulated by a variety of soluble growth factors ...
openaire +2 more sources
Growth Factors and Receptors of Lymphocytes
1987To understand molecular mechanisms of clonal expansion of lymphocytes we have isolated cDNA clones for two lymphokines, interleukins (IL) 4 and 5 that induce proliferation and maturation of B-lymphocytes. Structures of IL-4 and IL-5 revealed a remote homology with other lymphokines such as IL-3 and gamma-interferon.
T. Kinashi +13 more
openaire +2 more sources
Growth Factors, Growth-Factor Receptors and Oncogenes
Bio/Technology, 1985In this review we summarize the current knowledge of polypeptide growth factors, their receptors and oncogenes. Recent studies indicate that oncogenes are linked to growth factors and to growth factor receptors, suggesting that these molecules participate in the proliferation of normal and neoplastic cells.
R. M. Kris +3 more
openaire +1 more source
Growth factors and growth factor receptors.
British journal of hospital medicine, 1993Peptide growth factors and their cell surface-associated receptors are important determinants of normal and pathological growth reactions. Through signal transduction pathways, receptor occupancy triggers the production of intracellular downstream effector molecules which ultimately cause cell proliferation.
M R, Alison, N A, Wright
openaire +1 more source
Growth Factor Receptors: The Epidermal Growth Factor Receptor as a Model
1990Secreted polypeptide growth factors such as insulin, insulinlike growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and colony-stimulating factor (CSF-1) initiate complex cytoplasmic and nuclear events. These distinct cellular responses can be attributed to the interaction of hormones with their respective ...
K. C. Oberg, A. Brown, G. Carpenter
openaire +1 more source
International Journal of Neuroscience, 1985
Nerve growth factor is a polypeptide hormone that is required for the normal growth and development of the embryonic sensory and sympathetic nervous systems. On these cells, there are two different receptors for the nerve growth factor. Recently, these receptors have been isolated from three cell types and shown to have essentially the same binding ...
R W, Stach +3 more
openaire +2 more sources
Nerve growth factor is a polypeptide hormone that is required for the normal growth and development of the embryonic sensory and sympathetic nervous systems. On these cells, there are two different receptors for the nerve growth factor. Recently, these receptors have been isolated from three cell types and shown to have essentially the same binding ...
R W, Stach +3 more
openaire +2 more sources
Growth factors and receptors in cancer
Current Opinion in Biotechnology, 1991There have been a number of recent developments in mechanisms of action of growth factors and their receptors with particular relevance to cancer. The tyrosine kinase receptor family, in particular, has been shown to be important in tumour growth. These receptors are the products of oncogenes, or can interact with other oncogene pathways.
openaire +2 more sources
Growth factors, their receptors and development
American Journal of Medical Genetics, 1989AbstractThe hypothesis is put forward that the localized production of growth factors and the regulation both of their receptors and their receptor‐triggered transmembrane signaling reactions played an important role in organ development. The developing palate is used as an example to support this hypothesis.
openaire +2 more sources
Growth factor and growth factor receptor in radiation carcinogenesis
Radiation and Environmental Biophysics, 1991link_to_subscribed_fulltext
openaire +3 more sources