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Fibroblast growth factors and their receptors
Biochemistry and Cell Biology, 1997Fibroblast growth factors (FGFs) represent a group of polypeptide mitogens eliciting a wide variety of responses depending upon the target cell type. The knowledge of the cell surface receptors mediating the effects of FGFs has recently expanded remarkably. The complexity of the FGF family and the FGF-induced responses is reflected in the diversity and
John A. Smith +2 more
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Receptors for fibroblast growth factors
Immunology & Cell Biology, 1995SummaryThe recent discovery of the involvement of heparan sulfate proteoglycans (HSPG) in the activation of fibroblast growth factor receptors (FGFR) has led to an intensification of study of this field. It appears that the HSPG act as low affinity receptors to which the fibroblast growth factors (FGF) must bind in order to successfully activate the ...
John T Gallagher, Jacqueline C Coutts
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Epidermal growth factor receptors
Molecular and Cellular Biochemistry, 1981EGF-Rs are cell membrane glycoproteins of wide distribution. They have not yet been fully characterized or purified but are probably molecules of 170-190,000 mol. wt. in most cells. The growth factor EGF binds and will saturate cell surface receptors with a KA of about 5 X 10(9) M-1 although a receptor class with an affinity in excess of 10(10) M-1 has
Eileen D. Adamson, Anthony R. Rees
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Growth factor receptors and their ligands
Journal of Neuro-Oncology, 1994The understanding of the signal transduction cascade involving growth factors and their receptors is one major key for diagnostic and therapeutic improvements in human neoplasms. Using receptor autoradiography, an inverse relationship for the incidence of somatostatin receptors (SSR) and epidermal growth factor receptors (EGFR) was found in gliomas [1].
H Mueller, U Eppenberger
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Endocytosis of growth factor receptors
BioEssays, 1993AbstractBinding of a growth factor (GF) to its specific receptor on the cell surface causes the initiation of a signal transduction cascade which eventually results in mitosis. GF:receptor complexes are removed from the cell surface via receptor‐mediated endocytosis, a process which involves clathrin‐coated pits.
Alexander Sorkin, Christopher M. Waters
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Hematopoietic growth factor receptors
The International Journal of Cell Cloning, 1991The molecular cloning for most of the hematopoietic growth factor receptors has been achieved over the past few years and revealed that they can by assigned to two discrete receptor families, namely the hematopoietic growth factor superfamily (HRS) and the receptor tyrosine kinase family (RTK).
Luigi Pegoraro +2 more
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British Medical Bulletin, 1989
The initial interaction of growth factors with their target cells is mediated by specific high affinity cell surface receptors. The structural and functional diversity found in growth factors is more limited at the receptor level where receptors for structurally and functionally distinct factors seem to share structural motifs and employ a restricted ...
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The initial interaction of growth factors with their target cells is mediated by specific high affinity cell surface receptors. The structural and functional diversity found in growth factors is more limited at the receptor level where receptors for structurally and functionally distinct factors seem to share structural motifs and employ a restricted ...
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Growth Factors and Receptors of Lymphocytes
1987To understand molecular mechanisms of clonal expansion of lymphocytes we have isolated cDNA clones for two lymphokines, interleukins (IL) 4 and 5 that induce proliferation and maturation of B-lymphocytes. Structures of IL-4 and IL-5 revealed a remote homology with other lymphokines such as IL-3 and gamma-interferon.
Yuji Saito +13 more
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Receptors for Nerve Growth Factor
1993Publisher Summary This chapter discusses the two receptors for nerve growth factor (NGF)—namely, (1) the low-affinity NGF receptor and (2) the product of the proto-oncogene trk . It also reviews the way they were originally identified and the structural and functional features of the two receptors.
David S. Battleman +2 more
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Hematopoietic growth factor receptors
Cytotechnology, 1989The formation of the cellular constituents of the blood is regulated by a series of endogenous polypeptides with largely paracrine function. A number of these hematopoietic growth factors (HGF's), which include colony stimulating factors, interleukins, and erythropoietin, have been purified to homogeneity and cloned, which in turn has led to extensive ...
Malcolm A.S. Moore, Jae-Hung Shieh
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