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Astrocytes serve as integrative hubs regulating sleep and arousal. [PDF]
PLoS BiologyAstrocytes help control sleep and arousal. A new study in PLOS Biology shows that a wake-promoting signal called histamine affects how astrocytes respond to and modulate other brain signals and reduces time spent awake through astroglial histamine-1 ...
Ashley M Ingiosi
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The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions
Frontiers in Pharmacology, 2021 This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart.
Joachim Neumann +4 more
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Function and Role of Histamine H1 Receptor in the Mammalian Heart
Pharmaceuticals, 2023 Histamine can change the force of cardiac contraction and alter the beating rate in mammals, including humans. However, striking species and regional differences have been observed. Depending on the species and the cardiac region (atrium versus ventricle)
Joachim Neumann +4 more
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Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review
Brain Sciences, 2023 Background: Histamine is a widely distributed biogenic amine with multiple biological functions mediated by specific receptors that determine the local effects of histamine.
Lingyi Kong +2 more
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Histamine, histamine receptors, and neuropathic pain relief [PDF]
British Journal of Pharmacology, 2019 Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various physiological and pathological processes, including pain. In the last two decades, there has been a particular increase in evidence to support the involvement of H3 receptor and H4 receptor in the modulation of neuropathic pain, which remains challenging in terms ...
Ilona Obara +3 more
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Viruses, 2023 Although Kaposi’s sarcoma-associated herpesvirus (KSHV) has been reported to cause several human cancers including Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL), the mechanisms of KSHV-induced tumorigenesis, especially virus–host interaction ...
Jungang Chen +6 more
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Interactions between Histamine H1 and H3 and Dopamine D1 Receptors on feeding behavior in chicken [PDF]
Iranian Journal of Veterinary Medicine, 2017 BACKGROUND: Brain monoamines (such as histamine and dopamine) play an important role in emotions, cognition, reward and feeding behavior. The interactions between histamine and dopamine were studied in many physiological functions but this correlation is
Masood GhandForoushan +2 more
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Histamine Receptors: Ex Vivo Functional Studies Enabling the Discovery of Hits and Pathways
Membranes, 2023 Histamine receptors (HRs) are G-protein-coupled receptors involved in diverse responses triggered by histamine release during inflammation or by encounters with venomous creatures.
Andrea Seldeslachts +2 more
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Journal of Neuroinflammation, 2020 Background Microglia, the principal sentinel immune cells of the central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND).
Yi-Nan Chen +7 more
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