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Histamine and its receptors [PDF]
British Journal of Pharmacology, 2006 This article reviews the development of our knowledge of the actions of histamine which have taken place during the course of the 20th century. Histamine has been shown to have a key physiological role in the control of gastric acid secretion and a pathophysiological role in a range of allergic disorders.
C. Robin Ganellin, M. E. Parsons
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Histamine receptors and COVID-19 [PDF]
Inflammation Research, 2020 Reports that the over-the-counter histamine H2 receptor antagonist famotidine could help treat the novel coronavirus disease (COVID-19) appeared from April 2020. We, therefore, examined reports on interactions between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and histamine receptor antagonists.A systematic literature search was ...
Ennis, Madeleine, Tiligada, Katerina
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Histamine, histamine receptors, and neuropathic pain relief [PDF]
British Journal of Pharmacology, 2019 Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various physiological and pathological processes, including pain. In the last two decades, there has been a particular increase in evidence to support the involvement of H3 receptor and H4 receptor in the modulation of neuropathic pain, which remains challenging in terms ...
Ilona Obara +3 more
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Histamine receptors and cancer pharmacology [PDF]
British Journal of Pharmacology, 2010 Considerable evidence has been collected indicating that histamine can modulate proliferation of different normal and malignant cells. High histamine biosynthesis and content together with histamine receptors have been reported in different human neoplasias including melanoma, colon and breast cancer, as well as in experimental tumours in which ...
Elena Rivera +2 more
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Functional Diversity of Histamine and Histamine Receptors
Journal of Investigative Dermatology, 1992 In order to analyze the mechanisms by which a single biogenic amine like histamine is capable of inducing a wide variety of both physiologic and pathologic functions in various tissues/cells, histamine responses were dissected in detail from a biochemical and pharmacologic point of view.
Donald G. Payan, Masato Mitsuhashi
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Regulation of the immune response and inflammation by histamine and histamine receptors [PDF]
Journal of Allergy and Clinical Immunology, 2011 Histamine is a biogenic amine with extensive effects on many cell types, including important immunologic cells, such as antigen-presenting cells, natural killer cells, epithelial cells, and T and B lymphocytes. Histamine and its 4 receptors represent a complex system of immunoregulation with distinct effects dependent on receptor subtypes and their ...
O'Mahony Liam +2 more
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New Developments in the Use of Histamine and Histamine Receptors [PDF]
Current Allergy and Asthma Reports, 2010 Histamine and the histamine receptors are important regulators of a plethora of biological processes, including immediate hypersensitivity reactions and acid secretion in the stomach. In these roles, antihistamines have found widespread therapeutic applications, while the last receptor to be discovered, the H4 histamine receptor, has become a major ...
Craig Smuda, Paul J. Bryce
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Histamine and H1-histamine receptors faster venous circulation [PDF]
Journal of Cellular and Molecular Medicine, 2011 The study has analysed the action of histamine in the rabbit venous system and evaluated its potential role in contraction during increased venous pressure. We have found that a great variety exists in histamine sensitivity and H(1) -histamine receptor expression in various types of rabbit veins.
Galajda, Zoltán +12 more
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Histamine receptors in mammalian retinas [PDF]
Journal of Comparative Neurology, 2006 AbstractMammalian retinas are innervated by histaminergic axons that originate from perikarya in the posterior hypothalamus. To identify the targets of these retinopetal axons, we localized histamine receptors (HR) in monkey and rat retinas by light and electron microscopy.
Noga Vardi +3 more
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