Results 61 to 70 of about 49,569 (265)

Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. [PDF]

PLoS ONE, 2012
BACKGROUND:Histamine is detected in high concentrations in the airways during an allergic asthma response. In a murine model of allergic asthma, JNJ 7777120, an antagonist at the histamine H(4) receptor, reduces asthmatic symptoms, while the histamine H ...
Silke Beermann, Silke Glage, Danny Jonigk, Roland Seifert, Detlef Neumann   +4 more
doaj   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

ANTI-INFLAMMATORY AND ANTI-ALLERGIC FEATURES OF ANTIBODIES TO HISTAMINE IN RELEASE-ACTIVE FORM: REVIEW OF EXPERIMENTAL AND CLINICAL RESEARCHES

Детские инфекции (Москва), 2015
Preclinical and clinical studies of medical preparations (rengalin, ergoferon) containing release-active (P-A) antibodies to histamine confirmed their ability to provide anti-inflammatory and anti-allergic effect.
E. S. Zhavbert, Yu. L. Dugina, O. I. Epshtein   +2 more
doaj   +1 more source

HISTAMINE RECEPTORS

The Professional Medical Journal, 2010
Objective: This research work deals with the mechanism of action involved in determining the therapeutic potential of histamine and its blockers in gastrointestinal motility. Study Design: Rabbits of equal weights were used in this study. They were brought from the animal house of BMSI, sacrificed in the Pharmacology Research laboratory.
AFTAB TURABI, GHULAM ALI ASGHAR QURESHI, Muhammad ZIAULLAH, S. Saud Hasan   +3 more
openaire   +2 more sources

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Histamine and H1-histamine receptors faster venous circulation [PDF]

Journal of Cellular and Molecular Medicine, 2011
The study has analysed the action of histamine in the rabbit venous system and evaluated its potential role in contraction during increased venous pressure. We have found that a great variety exists in histamine sensitivity and H(1) -histamine receptor expression in various types of rabbit veins.
Galajda, Zoltan, Balla, Jozsef, Szentmiklosi, A Jozsef, Biro, Tamas, Czifra, Gabriella, Dobrosi, Nora, Cseppento, Agnes, Patonay, Lajos, Roszer, Tamas, Balla, Gyorgy, Popescu, Laurenciu M, Lekli, Istvan, Tosaki, Arpad   +12 more
openaire   +2 more sources

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Histamine Excites Rat Superior Vestibular Nuclear Neurons via Postsynaptic H1 and H2 Receptors in vitro

Neurosignals, 2012
The superior vestibular nucleus (SVN), which holds a key position in vestibulo-ocular reflexes and nystagmus, receives direct hypothalamic histaminergic innervations.
Qian-Xing Zhuang, Yong-Hui Wu, Guan-Yi Wu, Jing-Ning Zhu, Jian-Jun Wang   +4 more
doaj   +1 more source

Histamine receptors in mammalian retinas [PDF]

Journal of Comparative Neurology, 2006
AbstractMammalian retinas are innervated by histaminergic axons that originate from perikarya in the posterior hypothalamus. To identify the targets of these retinopetal axons, we localized histamine receptors (HR) in monkey and rat retinas by light and electron microscopy.
Matthew J, Gastinger, Alistair J, Barber, Noga, Vardi, David W, Marshak   +3 more
openaire   +2 more sources