Results 61 to 70 of about 618,319 (304)
Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia
Advanced Science, EarlyView.The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian +12 more
wiley +1 more source
Histamine, histamine receptors, and neuropathic pain relief [PDF]
Histamine, acting via distinct histamine H1 , H2 , H3 , and H4 receptors, regulates various physiological and pathological processes, including pain. In the last two decades, there has been a particular increase in evidence to support the involvement of ...
Telezhkin V +3 more
core +4 more sources
The Professional Medical Journal, 2010 Objective: This research work deals with the mechanism of action involved in determining the therapeutic potential of histamine and its blockers in gastrointestinal motility. Study Design: Rabbits of equal weights were used in this study. They were brought from the animal house of BMSI, sacrificed in the Pharmacology Research laboratory.
AFTAB TURABI +3 more
openaire +2 more sources
, 2007 The present study was designed to explore the expression and distribution of histamine H3 and H4 receptors within the rat gastric fundus by immunohistochemistry using our unique immunological probes.
SHENTON F. C. +7 more
core +1 more source
Annals of Neurology, EarlyView.Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl +10 more
wiley +1 more source
The Histamine H4 Receptor: From Orphan to the Clinic
Frontiers in Pharmacology, 2015 The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other histamine receptors and thus ...
Robin L. Thurmond
doaj +1 more source
Histamine in cancer immunology and immunotherapy. Current status and new perspectives
Pharmacology Research & Perspectives, 2021 Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront
María de la Paz Sarasola +3 more
doaj +1 more source
Histamine: A Mediator of Intestinal Disorders—A Review
Metabolites, 2022 Within the gastrointestinal tract, histamine is present at relatively high concentrations, especially during inflammatory processes. Histamine is a biogenic amine with numerous effects on many cell types, mediated by the activation of its four different ...
Sylwia Smolinska +3 more
doaj +1 more source
Histamine and H1-histamine receptors faster venous circulation [PDF]
Journal of Cellular and Molecular Medicine, 2011 The study has analysed the action of histamine in the rabbit venous system and evaluated its potential role in contraction during increased venous pressure. We have found that a great variety exists in histamine sensitivity and H(1) -histamine receptor expression in various types of rabbit veins.
Galajda, Zoltan +12 more
openaire +2 more sources
Histamine H3 Receptor Heterogeneity in the Central Nervous System in Aging and Dementia. [PDF]
, 2011 The histamine H3R is a classic G-protein coupled receptor and is a potential therapeutic target for a number of central nervous system pathologies. Major pharmacological heterogeneity between and within species has hindered the clinical development of ...
LETHBRIDGE, NATASHA,LOUSIE
core