Results 211 to 220 of about 23,298 (234)

Localization of histamine and histamine H2-receptor antagonists in the gastric mucosa

The Histochemical Journal, 1977
Histamine stimulates acid secretion by the parietal cell and this secretion is inhibited by the histamine H2-receptor antagonists. Whole body autoradiography showed that radioactivity from 14C-histamine was localized in the artery walls of the stomach and in the muscularis mucosae, but that the level in the fundic mucosa was the same as the blood. When
openaire   +3 more sources

Histamine H2 receptor: Involvement in gastric ulceration

Life Sciences, 1976
The involvement of the H1 and H2 receptors for histamine in the pathogenesis of gastric ulcers was investigated in rats. Metiamide, an H2 receptor antagonist, reliably reduced ulceration produced by stress alone or by a combination of stress and aspirin.
Thomas H. Brown, Patricia A. Brown, Joan Vernikos-Danellis   +2 more
openaire   +3 more sources

Prolactin responses to histamine H2 receptor antagonists

Acta Endocrinologica, 1980
Abstract. We have compared the effects of cimetidine and SK&F 92994, a new more potent histamine H2 receptor antagonist, on serum prolactin, and also assessed the effect of the H2 receptor agonist impromidine on the response to cimetidine. As previously reported, cimetidine 200 mg given as an iv bolus dose produced a marked rise in serum prolactin,
P. C. Sharpe, W. L. Burland, Jane G. Mills, G. V. Groom, M. A. Melvin   +4 more
openaire   +3 more sources

Analysis of the histamine H2-receptor in human monocytes

Biochemical Pharmacology, 2014
Histamine receptors are G-protein-coupled receptors (GPCRs). Canonically, the histamine H2-receptor (H2R) couples to Gs-proteins and activates adenylyl cyclases (ACs) with subsequent adenosine-3',5'-cyclic monophosphate (cAMP) generation. Recently, the classic two-state model describing GPCR activation has been extended to a multiple-state model ...
Roland Seifert, Detlef Neumann, Kristin Werner   +2 more
openaire   +3 more sources

Histamine H2-Receptors and Gastric Secretion

1978
In 1966 Ash and Schild1 pointed out for the first time the existence of different types of histamine receptors. They defined as H1 receptors those which could be blocked by the classical antihistaminics and non-H1 receptors those which could not be blocked.
openaire   +3 more sources

Histamine H2 receptors in rat renal glomeruli

Biochemical Pharmacology, 1982
The aim of this study was to demonstrate histamine-H2 receptors in glomeruli isolated from rat renal cortex and to correlate binding to stimulation by histamine of glomerular cyclic AMP concentration. Binding studies were performed at 10-12 degrees C using [3H]cimetidine as a tracer.
Jean-Paul Oudinet, Marie-Paule Nivez, Dominique Chansel, Raymond Ardaillou   +3 more
openaire   +3 more sources

Nephrotoxicity and Hepatotoxicity of Histamine H2 Receptor Antagonists

Drug Safety, 2001
The extensive use of selective histamine H2 receptor antagonists provides a unique opportunity to describe very rare adverse drug reactions. Although mild elevation of serum creatinine level following the administration of cimetidine is relatively common, acute interstitial nephritis (AIN) is a rare hypersensitivity reaction.
Alexander A. Fisher, David G. Le Couteur
openaire   +3 more sources

Conformational analyses on histamine H2-receptor antagonists

Journal of Computer-Aided Molecular Design, 1990
In a series of compounds with H2-antihistaminic activity, a conformational analysis was performed based on force field calculations. The drugs studied were cimetidine, ranitidine, famotidine, roxatidine and the conformationally more restricted ICI127032.
Hans-Dieter Höltje, Anita Batzenschlager   +1 more
openaire   +3 more sources

Histamin-H2-Receptor-Antagonismus

1978
Receptoren sind als hypothetische Orte an der Zelloberflache aufzufassen, deren Verbindung mit einem Agonisten (physiologischer Wirkstoff oder Pharmakon) von einer spezifischen Leistung der Zelle gefolgt ist. Antagonisten besitzen ebenfalls eine Affinitat zum Receptor, konnen aber die spezifische Wirkung in der Zelle nicht hervorrufen. Sie konkurrieren
openaire   +2 more sources

Characterization of an accessory binding area in the histamine H2 receptor

European Journal of Pharmacology: Molecular Pharmacology, 1991
The histamine H2 receptor-blocking activity of ranitidine and lamtidine analogues has been investigated to gain information on the structure of the receptor area adjacent to the site fitted by the polar group. The introduction of differently shaped alkyl moieties on the polar group is always accompanied by maintenance or by an increase of H2 receptor ...
ORSETTI, Marco Riccardo Lilio, SORBA G.
openaire   +3 more sources