Results 221 to 230 of about 23,298 (234)
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Multiple Signaling Pathways of Histamine H2 Receptors
1991Histamine H2 receptor (H2R) has been shown to be coupled to adenylate cyclase. However, we have previously demonstrated that H2R-specific stimulation also activated phospholipase C in human HL-60 promyelocytic leukemia cells (Mitsuhashi M. et al. J. Biol. Chem. 264:18356, 1989).
D G Payan, M Mitsuhashi
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Journal of Molecular Structure: THEOCHEM, 1985
Abstract The conformational energy maps and charge distributions of histamine and six H2-receptor agonists of histamine were determined in the CNDO/2 approach. When several tautomeric forms were possible only the NτH was considered. A judicious analysis of the conformational results, as a function of the H2-receptor activity, allows us to propose ...
F.J. Romero-Sánchez +2 more
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Abstract The conformational energy maps and charge distributions of histamine and six H2-receptor agonists of histamine were determined in the CNDO/2 approach. When several tautomeric forms were possible only the NτH was considered. A judicious analysis of the conformational results, as a function of the H2-receptor activity, allows us to propose ...
F.J. Romero-Sánchez +2 more
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H2 histaminic receptors in rat cerebral cortex. 3. Inhibition of [3H]histamine by H2 agonists
Biochemistry, 1985The binding of [3H]histamine to H2 receptors in homogenates of rat cerebral cortex is inhibited by 11 H2 agonists in a characteristic and unique manner. At low concentrations of the radioligand (less than 1.5 nM), the inhibitory profiles of individual agonists (A) are distinctly biphasic; specific binding is well described in most cases by the ...
Marianne Kandel +3 more
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Molecular Pharmacology, 1993
Recently we developed amthamine [2-amino-5-(2-aminoethyl)-4-methylthiazole]. This cyclic analogue of dimaprit proved to be the most potent and selective histamine H2 receptor agonist of a series of substituted 4- or 5-(2-aminoethyl)thiazoles. Quantum chemical studies on histamine (N pi-H tautomer), dimaprit, and amthamine revealed that, based upon ...
J C, Eriks +2 more
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Recently we developed amthamine [2-amino-5-(2-aminoethyl)-4-methylthiazole]. This cyclic analogue of dimaprit proved to be the most potent and selective histamine H2 receptor agonist of a series of substituted 4- or 5-(2-aminoethyl)thiazoles. Quantum chemical studies on histamine (N pi-H tautomer), dimaprit, and amthamine revealed that, based upon ...
J C, Eriks +2 more
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Histamine H2 Receptors and Lung Function
1991The lung is a complex tissue comprising many different cellular elements, including smooth muscle, both airway and vascular; vascular endothelium; respiratory epithelium; mucus-secreting cells; nerves; and connective tissue cells. The purpose of this review is to examine the evidence that histamine H2 receptors which may be present on these cells ...
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Histamine and histamine H1- and H2-receptor antagonists in acute inflammation [PDF]
Biochemical Society Transactions, 1980 D. A. A. Owen, D. F. Woodward
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Methods to determine the constitutive activity of histamine H2 receptors
2002Publisher Summary The histamine H 2 receptor belongs to the large family of G protein-coupled receptors (GPCRs) and is positively coupled to adenylate cyclase. This chapter discusses a variety of experimental approaches that can be used to determine the constitutive activity of the H 2 receptor or other G s -coupled receptors.
Martine J. Smit +4 more
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1980
Publisher Summary The overall effect of histamine on the airway smooth muscle is highly complex and depends on the algebraic sum of stimulatory and inhibitory actions of a mixed population of H 1 - and H 2 -receptors, which in general act in opposite directions.
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Publisher Summary The overall effect of histamine on the airway smooth muscle is highly complex and depends on the algebraic sum of stimulatory and inhibitory actions of a mixed population of H 1 - and H 2 -receptors, which in general act in opposite directions.
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Histamine H2 Receptor Antagonists and the Cardiovascular System
Pharmacological Research, 1993Giulio Bertaccini +2 more
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HISTAMINE H2-RECEPTORS AND PARATHYROID HORMONE SECRETION
The Lancet, 1980P. M. Christiansen +2 more
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