Results 91 to 100 of about 71,015 (314)

Expression of histamine receptors (H1, H2, and H3) in the rabbit endolymphatic sac: an immunohistochemical study

, 2008
Objective: The endolymphatic sac (ES) is part of the membranous labyrinth of the inner ear. Its central role in immunologic activity within the inner ear has been confirmed by numerous studies.
Gamze Mocan Kuzey, Bayazit, Yildirim, MOCAN KUZEY, GAMZE, Dagli, Muharrem, Muharrem Dagli, Celil Gocer, Gocer, Cehl, Eryilmaz, Adil, Yildirim Bayazit, Goksu, Nebil, Nebil Goksu, Adil Eryilmaz, Banu Dogan Gun, DOĞAN GÜN, BANU   +13 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Potential of the Trifunctional Bispecific Antibody Surek Depends on Dendritic Cells: Rationale for a New Approach of Tumor Immunotherapy

Molecular Medicine, 2013
Trifunctional bispecific antibodies (trAbs) used in tumor immunotherapy have the unique ability to recruit T cells toward antigens on the tumor cell surface and, moreover, to activate accessory cells through their immunoglobulin Fc region interacting ...
Nina Eissler, Josef Mysliwietz, Nina Deppisch, Peter Ruf, Horst Lindhofer, Ralph Mocikat   +5 more
doaj   +1 more source

Toll-like receptors and inflammatory bowel disease

The fundamental purpose of the innate immune system is to protect a host against pathogens. In this context, the innate immune system in the gastrointestinal tract is unique because of the numerous foreign organisms such as bacteria living within it ...
Fukata, Masayuki, Abreu, Maria T
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV Trans Infection

mBio, 2014
A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded ...
Vinayaka R. Prasad, Michael I. Bukrinsky
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva (TM)): Mechanisms of action [PDF]

, 2004
Psoriasis is a chronic, incurable, auto-immune disorder with cutaneous manifestations. New evidence on the central role of the immune system in the pathogenesis of psoriasis increasingly provides insight into pathogenic steps that can be modulated to ...
Caro, I., Jullien, D., Langley, RGB, Dedrick, R., Prinz, Jörg Christoph, Joshi, A., Natta, P., Dummer, W.   +7 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human Natural Killer cells [PDF]

, 2010
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling.
Mehrabi, M, Brzostek, Joanna, Nigel J Burroughs, Stephane Oddos, Nigel J. Burroughs, Harrison, A, Van der Merwe, Philip Anton, Eissmann, P, Miloserdov, V, Maryam Mehrabi, Daniel M Davis, Koehler, Karsten, Daniel M. Davis, Gould, K, Alice Harrison, Köhler, K, Harrison Alice, Eissmann, Philipp, Oddos, S, Shiqiu Xiong, Davis, Daniel M., Köhler Karsten, Xiong, S, Burroughs, NJ, Köhler, Karsten, Cordoba, Shaun-Paul, Philipp Eissmann, Oddos, Stephane, Xiong, Shiqiu, Miloserdov, Vladimir, Gould Keith, Philip Anton van der Merwe, Davis, DM, Mehrabi, Maryam, Xiong Shiqiu, Cordoba, SP, Burroughs, Nigel J, Davis Daniel M., Miloserdov Vladimir, van der Merwe, PA, Brzostek, J, van der Merwe Philip Anton, Mehrabi Maryam, Karsten Köhler, Burroughs Nigel J., Harrison, Alice, Joanna Brzostek, Cordoba, Shaun Paul, Oddos Stephane, van der Merwe, Philip, Shaun-Paul Cordoba, Burroughs, Nigel J., Cordoba Shaun-Paul, Davis, Daniel M, Burroughs, Nigel John, Gould, Keith, Keith Gould, Vladimir Miloserdov, Eissmann Philipp, Brzostek Joanna   +59 more
core   +1 more source