Results 71 to 80 of about 636,775 (308)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]

, 2007
Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D., Groot-Kormelink, P., Plested, A.J.R., Sivilotti, L.G.   +3 more
core  

Improving the Effectiveness of Adjuvants: Targeting Innate Immune Receptors with a Special Focus on Toll-like Receptor Agonists

مجله دانشکده پزشکی اصفهان, 2013
The development of potent and safe adjuvants for generating vaccines capable of inducing protective and long lasting immunity has become an expanding field in vaccine development.
Seyed-Elias Tabatabaeizadeh, Alireza Haghparast   +1 more
doaj  

Anti-Ids in Allergy: Timeliness of a Classic Concept

World Allergy Organization Journal, 2010
Anti-idiotypic antibodies (anti-ids) are part of natural immune responses with regulatory capacity. Their effect on an antigen-specific, so-called Ab1 antibody response, is dependent on 1) the original antigen, which they mirror, being Ab2 antibodies ...
Julia Wallmann, MSc, Isabella Pali-Schöll, PhD, Erika Jensen-Jarolim, MD   +2 more
doaj   +1 more source

Harnessing the non-specific immunogenic effects of available vaccines to combat COVID-19

Human Vaccines & Immunotherapeutics, 2021
No proven remedy is identified for COVID-19 yet. SARS-CoV-2, the viral agent, is recognized by some endosomal and cytosolic receptors following cell entry, entailing innate and adaptive immunity stimulation, notably through interferon induction ...
Pouria Mosaddeghi, Farbod Shahabinezhad, Mohammadreza Dorvash, Mojtaba Goodarzi, Manica Negahdaripour   +4 more
doaj   +1 more source

Co-Receptors and Recognition of Self at the Immunological Synapse [PDF]

, 2009
The co-receptors CD4 and CD8 are important in the activation of T cells primarily because of their ability to interact with the proteins of the MHC enhancing recognition of the MHC-peptide complex by the T cell receptor (TCR). An antigen-presenting cell presents a small number of antigenic peptides on its MHC molecules, in the presence of a much larger
Nicholas R J, Gascoigne, Tomasz, Zal, Pia P, Yachi, John A H, Hoerter   +3 more
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]

, 2011
GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Errington, Adam C., Di Giovanni, Giuseppe, Crunelli, Vincenzo   +2 more
core  

Immunologic aspects of preeclampsiaAJOG Global Reports at a Glance

AJOG Global Reports
Preeclampsia is a syndrome with multiple etiologies. The diagnosis can be made without proteinuria in the presence of dysfunction of at least 1 organ associated with hypertension. The common pathophysiological pathway includes endothelial cell activation,
Henri Boulanger, MD, Stéphane Bounan, MD, Amel Mahdhi, MD, Dominique Drouin, MD, Salima Ahriz-Saksi, MD, Fabien Guimiot, PhD, Nathalie Rouas-Freiss, PD, PhD   +6 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source