Results 51 to 60 of about 71,015 (314)

Vitamin D and immunomodulation in the skin: a useful affirmative nexus

Exploration of Immunology, 2021
Skin is the largest organ of the body having multifunctional activities. It has a dynamic cellular network with unique immunologic properties to maintain defensive actions, photoprotection, immune response, inflammation, tolerogenic capacity, wound ...
Saptadip Samanta
doaj   +1 more source

Identification of serine 867 as new phosphorylation site on the GABA(B) receptor : characterization of physiological effects [PDF]

, 2011
The GABAB receptor is the metabotropic receptor for γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the mammalian central nervous system (CNS). The functional receptor is a heteromer consisting of a GABAB1 and GABAB2 subunit.
Abdel Aziz, Said
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The bradykinin-forming cascade in anaphylaxis and ACE-inhibitor induced angioedema/airway obstruction

Frontiers in Allergy
Anaphylaxis is a potentially life-threatening multi-system allergic reaction to a biological trigger resulting in the release of potent inflammatory mediators from mast cells and basophils and causing symptoms in at least two organ systems that generally
Berhane Ghebrehiwet, Kusumam Joseph, Allen P. Kaplan   +2 more
doaj   +1 more source

Uncovering the Mast Cell Response to Mycobacterium tuberculosis

Frontiers in Immunology, 2022
The immunologic mechanisms that contribute to the response to Mycobacterium tuberculosis infection still represent a challenge in the clinical management and scientific understanding of tuberculosis disease.
Ivonne Torres-Atencio, Ivonne Torres-Atencio, Ariadne Campble, Amador Goodridge, Margarita Martin, Margarita Martin   +5 more
doaj   +1 more source

Immunologic Effects of the Renin-Angiotensin System.

, 2017
Inappropriate activation of the renin-angiotensin system (RAS) exacerbates renal and vascular injury. Accordingly, treatment with global RAS antagonists attenuates cardiovascular risk and slows the progression of proteinuric kidney disease.
Rudemiller, Nathan P, Nathan P. Rudemiller, Crowley, Steven D, Steven D. Crowley   +3 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Macrophage pattern recognition receptors in immunity, homeostasis and self tolerance.

, 2009
Macrophages, a major component of innate immune defence, express a large repertoire of different classes of pattern recognition receptors and other surface antigens which determine the immunologic and homeostatic potential of these versatile cells.
Plüddemann, A, Subhankar Mukhopadhyay, Gordon, S, Mukhopadhyay, S, Gordon, Siamon, Annette Plüddemann, Siamon Gordon   +6 more
core   +1 more source

Co-Receptors and Recognition of Self at the Immunological Synapse [PDF]

, 2009
The co-receptors CD4 and CD8 are important in the activation of T cells primarily because of their ability to interact with the proteins of the MHC enhancing recognition of the MHC-peptide complex by the T cell receptor (TCR). An antigen-presenting cell presents a small number of antigenic peptides on its MHC molecules, in the presence of a much larger
Nicholas R J, Gascoigne, Tomasz, Zal, Pia P, Yachi, John A H, Hoerter   +3 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source