Molecular Oncology, EarlyView.Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley +1 more source
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Diagnostic Value Parameters Of Acute Phase Reactances Of Infectious-inflammatory Process In Diagnostics Of Early Neonatal Sepsis [PDF]
, 2018 An advanced progress of clinical neonatology in recent years has enabled to achieve considerable success in newborn management with due respect to both medical treatment and general care, especially in the group of neonates with low body weight at birth.
Bezrukov, L. (Leonid) +2 more
core +2 more sources
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
A hepatitis C virus (HCV) fertőzés pathogenesise: a genetikai és az immunológiai tényezők, valamint az oxidativ stress szerepe és a kórokozó virus sajátosságai, különös tekintettel a HCV-okozta betegségekben és a tünetmentes virushordozó állapotban = Pathogenesis of hepatitis C virus (HCV) infection: the role of the genetic and immunological factors, the oxidative stress and the viral features in the HCV-related diseases and in the symptomfree virus carriers [PDF]
, 2009 Genetikai, immunológiai és környezeti tényezők potenciális szerepe krónikus hepatitis C virus (HCV) infekcióban: összehasonlitó vizsgálatok aktiv HCV hepatitises betegekben és tünetmentes "egészséges" virushordozókban. 1.
Berki, Timea +5 more
core
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
The Emergence of Universal Immune Receptor T Cell Therapy for Cancer
Frontiers in Oncology, 2019 Chimeric antigen receptor (CAR) T cells have shown great success in the treatment of CD19+ hematological malignancies, leading to their recent approval by the FDA as a new cancer treatment modality. However, their broad use is limited since a CAR targets
Nicholas G. Minutolo +8 more
doaj +1 more source
Mutations in the _SC4MOL_ gene encoding a novel methyl sterol oxidase cause autosomal recessive psoriasisiform dermatitis, microcephaly and developmental delay [PDF]
, 2008 Disorders of cholesterol biosynthesis have clinical manifestations involving skeleton, eyes, neurologic development, and skin. We describe a patient with congenital cataracts, developmental delay, microcephaly, and low serum cholesterol who developed ...
Abbe Vallejo +8 more
core +1 more source
Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. [PDF]
, 2014 Complex interactions between the immune system and the brain might have important aetiological and therapeutic implications for neuropsychiatric brain disorders.
Cousins, Lesley +5 more
core +2 more sources
Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
FEBS Open Bio, EarlyView.Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa +13 more
wiley +1 more source