Results 211 to 220 of about 46,914 (246)

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Enzymatic Synthesis of Enantiopure (R)‐Citronellal from Geraniol via a Short‐Chain Dehydrogenase and Ene Reductase

Advanced Synthesis &Catalysis, EarlyView.
A synthetic cascade with two consecutive biocatalytic steps consisting of a short‐chain alcohol dehydrogenase and an ene reductase in a biphasic system provides (R)‐citronellal with >90% conversion and >99% enantiomeric excess from inexpensive geraniol. The development of synthetic routes to produce enantiopure (R)‐citronellal as a key intermediate for
Claudia Ferrer‐Carbonell, Rocio Villa, Iris Viskaal, Diederik J. Opperman, Caroline E. Paul   +4 more
wiley   +1 more source

Dendritic cells and the balance between transplant tolerance and immunity [PDF]

, 1996
Lu, L, Starzl, TE, Steptoe, RJ, Thomson, AW   +3 more
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The Immunology of the Insulin Receptor

Immunological Communications, 1976
We have detected and characterized anti-insulin-receptor autoantibodies which circulate in several patients with insulin resistance diabetes. These antibodies are predominantly IgG and are polyclonal. They inhibit insulin binding to its receptor on a variety of tissues from widely separated species. Antibodies obtained from different patients appear to
David B. Jarrett, Jeffrey S. Flier, C. R. Kahn, Jesse Roth   +3 more
openaire   +3 more sources

THE ONTOGENY OF IMMUNOLOGICAL RECEPTORS IN THE THYMUS

Acta Pathologica Microbiologica Scandinavica Series C: Immunology, 1982
Receptors for sheep erythrocytes, for the Fc part of IgG (FcyR) and IgM (FcμR), and for components of activated human complement C3 (C3bR and C3dR) in thymus tissue from fetuses, infants and children were studied using haemadsorption to cryostat sections in a closed chamber.
Olav Tönder, Nils Erik Gilhus, Stein Frostad, Roald Matre   +3 more
openaire   +3 more sources

Engineered bacterial receptors in immunology

Current Opinion in Immunology, 1993
Gram-positive surface receptors, such as staphylococcal protein A ans streptococcal protein G, have been genetically engineered for many applications in the field of immunology, including detection antigens, affinity purification of fusion proteins and display of heterologous epitopes on the surface of bacterial cells.
Stefan Ståhl, Anders Sjölander, Mathias Uhlén, Per-Åke Nygren   +3 more
openaire   +3 more sources

Antigen-receptor degeneracy and immunological paradigms [PDF]

Molecular Immunology, 2004
This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.
Sorin Solomon, Irun R. Cohen, Uri Hershberg   +2 more
openaire   +2 more sources

New immunology—immunology of pattern recognition receptors

Biology Bulletin, 2006
Pattern recognition receptors (PRRs) have been found on all cells of the body—cells of the innate and adaptive immune systems, epithelial and endothelial cells, keratinocytes, etc. PRRs can recognize specific molecular structures of microorganisms as well as allergens and other substances.
K. A. Lebedev, I. D. Ponyakina
openaire   +2 more sources

Is schizophrenia an immunologic receptor disorder?

Medical Hypotheses, 1983
A model is proposed for an autoimmune etiology for schizophrenia. We propose that schizophrenia is a syndrome (not a disease). We suggest that autoantibodies (and/or cell-mediated immunity) directed against autologous neurotransmitter receptors are responsible for the ebb and flow of psychotic symptomatology.
H. D. Whitten, E. Merler, H. Hugh Fudenberg, O. Farmati   +3 more
openaire   +3 more sources

Immunological of the Thyrotropin Receptor

Immunological Communications, 1976
Antibodies to the thyrotropin receptor appear to be responsible for hyperthyroidism in Graves' disease. The antibodies, described as thyroid-stimulating antibodies (TSAb) mimic the effects of thyrotropin (TSH) by binding to the TSH receptor and activating adenylate cyclase.
openaire   +3 more sources