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The Immunology of the Insulin Receptor
Immunological Communications, 1976We have detected and characterized anti-insulin-receptor autoantibodies which circulate in several patients with insulin resistance diabetes. These antibodies are predominantly IgG and are polyclonal. They inhibit insulin binding to its receptor on a variety of tissues from widely separated species. Antibodies obtained from different patients appear to
David B. Jarrett +3 more
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THE ONTOGENY OF IMMUNOLOGICAL RECEPTORS IN THE THYMUS
Acta Pathologica Microbiologica Scandinavica Series C: Immunology, 1982Receptors for sheep erythrocytes, for the Fc part of IgG (FcyR) and IgM (FcμR), and for components of activated human complement C3 (C3bR and C3dR) in thymus tissue from fetuses, infants and children were studied using haemadsorption to cryostat sections in a closed chamber.
Olav Tönder +3 more
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Engineered bacterial receptors in immunology
Current Opinion in Immunology, 1993Gram-positive surface receptors, such as staphylococcal protein A ans streptococcal protein G, have been genetically engineered for many applications in the field of immunology, including detection antigens, affinity purification of fusion proteins and display of heterologous epitopes on the surface of bacterial cells.
Stefan Ståhl +3 more
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Antigen-receptor degeneracy and immunological paradigms [PDF]
Molecular Immunology, 2004 This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.
Sorin Solomon +2 more
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New immunology—immunology of pattern recognition receptors
Biology Bulletin, 2006Pattern recognition receptors (PRRs) have been found on all cells of the body—cells of the innate and adaptive immune systems, epithelial and endothelial cells, keratinocytes, etc. PRRs can recognize specific molecular structures of microorganisms as well as allergens and other substances.
K. A. Lebedev, I. D. Ponyakina
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Is schizophrenia an immunologic receptor disorder?
Medical Hypotheses, 1983A model is proposed for an autoimmune etiology for schizophrenia. We propose that schizophrenia is a syndrome (not a disease). We suggest that autoantibodies (and/or cell-mediated immunity) directed against autologous neurotransmitter receptors are responsible for the ebb and flow of psychotic symptomatology.
H. D. Whitten +3 more
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Immunological of the Thyrotropin Receptor
Immunological Communications, 1976Antibodies to the thyrotropin receptor appear to be responsible for hyperthyroidism in Graves' disease. The antibodies, described as thyroid-stimulating antibodies (TSAb) mimic the effects of thyrotropin (TSH) by binding to the TSH receptor and activating adenylate cyclase.
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Immunology of the Acetylcholine Receptor
Immunological Communications, 1976Myasthenia gravis is a spontaneously occurring autoimmune disease in which antibodies and lymphocytes are specifically reactive with nicotinic ACh receptors of skeletal muscle. Antibodies reactive with junctional receptors of human muscle are found in 90% of patients with myasthenia gravis and not at all in other diseases.
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