Results 261 to 270 of about 636,775 (308)
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Immunological approaches for probing receptor structure and function
Trends in Pharmacological Sciences, 1991Molecular cloning has revealed the primary sequence of numerous membrane receptors, and this information catalysed two important efforts: modeling of receptor structure by hydropathy analysis and generating sequence-specific immunological probes with which these models can be tested experimentally.
S W, Bahouth, H Y, Wang, C C, Malbon
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Somatostatin receptor expression in clinical immunology
Metabolism, 1996Specific somatostatin receptors (ssts) have been described in normal and tumor tissues and identified on more than 95% of normal mitogen-activated human peripheral lymphocytes. Somatostatin may modulate the immune response by a variety of mechanisms, most of which are inhibitory, sst scintigraphy in patients with immune-mediated diseases revealed sst ...
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Immunological role of TAM receptors in the cancer microenvironment
2020TAM receptors belong to the family of receptor tyrosine kinases, comprising of Tyro3, Axl and Mertk receptors (TAMs) and are important homeostatic regulators of inflammation in higher eukaryotes. Along with their ligands, Gas6 and ProteinS, TAMs acts as receptors to phosphatidylserine (PtdSer), an anionic phospholipid that becomes externalized on the ...
Varsha, Gadiyar +2 more
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Immunology of bile acids regulated receptors
Progress in Lipid ResearchBile acids are steroids formed at the interface of host metabolism and intestinal microbiota. While primary bile acids are generated in the liver from cholesterol metabolism, secondary bile acids represent the products of microbial enzymes. Close to 100 different enzymatic modifications of bile acids structures occur in the human intestine and ...
Fiorucci, Stefano +6 more
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UP-REGULATION OF LACTOGENIC RECEPTORS - AN IMMUNOLOGICAL ARTIFACT?
Endocrinology, 1982We examined whether injection of heterologous hormones for more than one week might evoke a humoral immune response which would simulate receptor induction. Male rats were injected daily for ten days with human growth hormone (hGH) or ovine prolactin (oPRL), and binding of 125I-hGH and 125I-oPRL was examined in serum and in membranes from liver and ...
J P, Hughes, H P, Elsholtz, H G, Friesen
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Immunology of the Nicotinic Acetylcholine Receptor
1979The classical surface antigens of Enterobacteriaceae: 0, K, and H antigens have been studied extensively in the past and have provided a basis for the taxonomy of this family (Kauffmann, 1966, 1975). In comparison to the vast knowledge accumulated on the structure, localization, genetic determination, and biologic effects of O and K antigens (Weinbaum ...
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Fc Receptors in Mucosal Immunology
2015Immunoglobulin A (IgA) is the most prevalent antibody class at mucosal surfaces. In addition to protecting mucosal surfaces by preventing invasion of pathogens, IgA can interact with multiple IgA receptors by binding to the Fc tail, carbohydrate side chains, or accessory molecules. The best characterized IgA Fc receptor is FcαRI (CD89), which acts as a
van Egmond, Marjolein +2 more
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Immunological functions of the neuropilins and plexins as receptors for semaphorins
Nature Reviews Immunology, 2013Semaphorins were originally identified as axon-guidance molecules that function during neuronal development. However, cumulative evidence indicates that semaphorins also participate in immune responses, both physiological and pathological, and they are now considered to be potential diagnostic and/or therapeutic targets for a range of diseases.
Atsushi, Kumanogoh, Hitoshi, Kikutani
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Immunological aspects of acetycholine receptors
Trends in Neurosciences, 1983Abstract Monoclonal antibodies raised against purified acetycholine receptor (AChR) can be used as probes for defining its structure and function, and, indirectly, for defining the binding sites of antibodies from patients with the muscle disease myasthenia gravis (MG).
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Immunologic Analysis of the Acetylcholine Receptor
1986Studies of receptors have come a long way in the past decade or so. It is no longer possible to study their pharmacological or electrophysiological properties without serious consideration of their macromolecular properties. A cascade of new techniques (e.g., affinity labeling, affinity purification, reconstitution, patch clamping, monoclonal antibody ...
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