Results 21 to 30 of about 179 (100)
Structural and Functional Features of the P2X4 Receptor: An Immunological Perspective [PDF]
Frontiers in Immunology, 2021 Extracellular nucleotides are important mediators of activation, triggering various responses through plasma membrane P2 and P1 receptors. P2 receptors are further subdivided into ionotropic P2X receptors and G protein-coupled P2Y receptors. P2X4 is an ATP-gated cation channel broadly expressed in most tissues of the body.
Kanellopoulos, Jean M +3 more
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Purinergic Regulation of Neutrophil Function
Frontiers in Immunology, 2018 Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through ...
Xu Wang, Deyu Chen
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Anaphylatoxins spark the flame in early autoimmunity
Frontiers in Immunology, 2022 The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate and adaptive immune cells, the activation of which ...
Jovan Schanzenbacher +3 more
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Neonatal innate immunity and Toll-like receptor [PDF]
Korean Journal of Pediatrics, 2010 The innate immune response is the first line of defense against microbial infections. Innate immunity is made up of the surface barrier, cellular immunity and humoral immunity.
Hye Sun Yoon
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Flow Cytometric Analysis of Calcium Influx Assay in T cells
Bio-Protocol, 2013 Calcium influx is one of the key signaling events upon stimulation of T cell receptors (TCR) and plays an important role for T cell activation, proliferation, and differentiation.
Sun-Hwa Lee
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Viruses, 2022 Herpes simplex virus type 1 (HSV-1), an α subgroup member of the human herpesvirus family, infects cells via the binding of its various envelope glycoproteins to cellular membrane receptors, one of which is herpes virus entry mediator (HVEM), expressed ...
Yang Gao +25 more
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Immunity to pathogens taught by specialized human dendritic cell subsets.
Frontiers in Immunology, 2015 Dendritic cells (DC) are specialized antigen-presenting cells (APC) that have a key role in immune responses, because they bridge the innate and adaptive arms of the immune system.
Jens A. E. Geginat +7 more
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Toll-like receptors in control of immunological autophagy [PDF]
Cell Death & Differentiation, 2009 Autophagy is a cell biological process, enabling cells to autodigest their own cytosol when starved, remove cytoplasmic protein aggregates too large for proteasomal degradation, eliminate aberrant or over-proliferated organelles, and sanitize the cytoplasm by killing intracellular microbes.
Vojo Deretic, Mónica A. Delgado
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Application of built-in adjuvants for epitope-based vaccines [PDF]
PeerJ, 2019 Several studies have shown that epitope vaccines exhibit substantial advantages over conventional vaccines. However, epitope vaccines are associated with limited immunity, which can be overcome by conjugating antigenic epitopes with built-in adjuvants (e.
Yao Lei +6 more
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Vitamin D and immunomodulation in the skin: a useful affirmative nexus
Exploration of Immunology, 2021 Skin is the largest organ of the body having multifunctional activities. It has a dynamic cellular network with unique immunologic properties to maintain defensive actions, photoprotection, immune response, inflammation, tolerogenic capacity, wound ...
Saptadip Samanta
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