Results 21 to 30 of about 112,504 (296)

Topological and Structural Plasticity of the Single Ig Fold and the Double Ig Fold Present in CD19

Biomolecules, 2021
The Ig fold has had a remarkable success in vertebrate evolution, with a presence in over 2% of human genes. The Ig fold is not just the elementary structural domain of antibodies and TCRs, it is also at the heart of a staggering 30% of immunologic cell ...
Philippe Youkharibache
doaj   +1 more source

The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus Monkeys

Frontiers in Genetics, 2021
The coronavirus disease 2019 (COVID-19) pandemic, induced by the pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly all over the world. There is considerable variability among neonates, children, and adults in the
Bangrong Cao, Liping Zhang, Huifen Liu, Shiqi Ma, Kun Mi   +4 more
doaj   +1 more source

Immunopathogenesis of rheumatoid arthritis [PDF]

, 2017
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an immune-mediated etiology associated with stromal tissue dysregulation that
Ahmed, Ai, Ai, Anzilotti, Arend, Astorri, Benham, Bombardieri, Bottini, Bottini, Byng-Maddick, Catrina, Catrina, Charles-Schoeman, Christophorou, Corsiero, Croft, de Aquino, de Hair, Deane, Dennis, Diarra, Ekwall, El-Gabalawy, Ferreira, Filer, Firestein, Firestein, Firestein, Firestein, Firestein, Fonseca, Franz, Gary S. Firestein, Genovese, Hammaker, Harre, Hill, Horiuchi, Huber, Iain B. McInnes, Joosten, Juarez, Kaminsky, Karouzakis, Kelly, Kiener, Kim, Kinslow, Kirschmann, Klarenbeek, Konig, Konig, Krishnadas, Krishnamurthy, Källberg, Langley, Law, Lee, Lefèvre, Linn-Rasker, Liu, Lubberts, Lundström, Makrygiannakis, Matsumoto, McInnes, McInnes, McInnes, McInnes, McKellar, Miossec, Mydel, Müller-Ladner, Nakamachi, Nakano, Nakano, Nam, Okada, Pap, Perlman, Pitzalis, Randen, Rawlings, Raychaudhuri, Raza, Reynisdottir, Reynisdottir, Robertson, Rodríguez-Carrio, Rombouts, Rossetti, Scally, Scher, Schiff, Shi, Shi, Smolen, Smolen, Snir, Sokolove, Stanczyk, Suzuki, Tan, Tran, Tsaprouni, van Beers, van der Helm-van Mil, Vassallo, Wang, Wegner, Weyand, Yamamoto, Yang, Zhang, Zvaifler   +115 more
core   +1 more source

What Is the Correlation between Preeclampsia and Cancer? The Important Role of Tachykinins and Transition Metal Ions

Pharmaceuticals, 2023
Metal ions are irreplaceable in many biological processes. They are components of numerous metalloproteins and serve as cofactors or structural elements for enzymes.
Klaudia Szczerba, Kamila Stokowa-Soltys
doaj   +1 more source

Structural Immunology of Complement Receptors 3 and 4 [PDF]

Frontiers in Immunology, 2018
Complement receptors (CR) 3 and 4 belong to the family of beta-2 (CD18) integrins. CR3 and CR4 are often co-expressed in the myeloid subsets of leukocytes, but they are also found in NK cells and activated T and B lymphocytes. The heterodimeric ectodomain undergoes considerable conformational change in order to switch the receptor from a structurally ...
Thomas Vorup-Jensen, Thomas Vorup-Jensen, Rasmus Kjeldsen Jensen   +2 more
openaire   +6 more sources

High-throughput Sequencing Based Immune Repertoire Study during Infectious Disease

Frontiers in Immunology, 2016
The selectivity of the adaptive immune response is based on the enormous diversity of T and B cell antigen-specific receptors. The immune repertoire, the collection of T and B cells with functional diversity in the circulatory system at any given time ...
Dongni Hou, Cuicui Chen, Eric John Seeley, Shujing Chen, Yuanlin Song   +4 more
doaj   +1 more source

Cortisol patterns are associated with T cell activation in HIV. [PDF]

, 2012
ObjectiveThe level of T cell activation in untreated HIV disease is strongly and independently associated with risk of immunologic and clinical progression. The factors that influence the level of activation, however, are not fully defined.
Acree, Michael, Bacchetti, Peter, Deeks, Steven G, Epel, Elissa, Epling, Lorrie, Hecht, Frederick M, Kemeny, Margaret E, Kirschbaum, Clemens, Moran, Patricia, Patterson, Sarah, Sinclair, Elizabeth   +10 more
core   +3 more sources

Effects of Parathyroid Hormone on Immune Function

Clinical and Developmental Immunology, 2010
Parathyroid hormone (PTH) function as immunologic mediator has become interesting with the recent usage of PTH analogue (teriparatide) in the management of osteoporosis.
Abdallah Sassine Geara, Mario R. Castellanos, Claude Bassil, Georgia Schuller-Levis, Eunkue Park, Marianne Smith, Michael Goldman, Suzanne Elsayegh   +7 more
doaj   +1 more source

Peroxisome proliferator-activated receptor agonists (PPARs): a promising prospect in the treatment of psoriasis and psoriatic arthritis [PDF]

Anais Brasileiros de Dermatologia, 2013
Psoriasis is a polygenic, inflammatory and progressive disease, characterized by an abnormal differentiation and hyperproliferation of keratinocytes, associated with impaired immunologic activation and systemic disorders, while psoriatic arthritis is a ...
Emerson de Andrade Lima, Mariana Modesto Dantas de Andrade Lima, Cláudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte, Ivan da Rocha Pita, Maira Galdino da Rocha Pita   +5 more
doaj   +1 more source

The Effector Function of Allergens

Frontiers in Allergy, 2022
Allergens are antigens that generate an IgE response (sensitization) in susceptible individuals. The allergenicity of an allergen can be thought of in terms of its ability to sensitize as well as its ability to cross-link IgE/IgE receptor complexes on ...
Stéphane Hazebrouck, Nicole Canon, Stephen C. Dreskin   +2 more
doaj   +1 more source