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Alcohol-related liver disease (ALD) became an important health issue worldwide. Following chronic alcohol consumption, the development of ALD might be caused by metabolic and immunologic factors, such as reactive oxygen species (ROS) and pro-inflammatory
Tom Ryu+4 more
doaj +1 more source
New and emerging therapeutic options for malignant pleural mesothelioma: review of early clinical trials. [PDF]
Malignant pleural mesothelioma (MPM) is a rare tumor that is challenging to control. Despite some benefit from using the multimodality-approach (surgery, combination chemotherapy and radiation), survival remains poor. However, current research produced a
Cameron, Robert B+2 more
core +2 more sources
Purinergic Regulation of Neutrophil Function
Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through ...
Xu Wang, Deyu Chen
doaj +1 more source
DR-bearing T lymphocytes in thoracic duct lymph [PDF]
T cells having DR antigens were shown to be present in high numbers in the thoracic duct lymph of patients undergoing long-term drainage. As drainage progresses the proportion of T DR cells in the lymph increases to levels as high as 70% at 6 weeks ...
Abo+25 more
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Anaphylatoxins spark the flame in early autoimmunity
The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate and adaptive immune cells, the activation of which ...
Jovan Schanzenbacher+3 more
doaj +1 more source
Eplet mismatch analysis in kidney transplantation: from concept to clinical practice
Eplet mismatch analysis offers a refined approach to assessing donor-recipient compatibility in kidney transplantation, surpassing conventional antigen-level human leukocyte antigen (HLA) matching in predicting immunologic outcomes.
Hyeyoung Lee, Eun-Jee Oh
doaj +1 more source
Neonatal innate immunity and Toll-like receptor [PDF]
The innate immune response is the first line of defense against microbial infections. Innate immunity is made up of the surface barrier, cellular immunity and humoral immunity.
Hye Sun Yoon
doaj +1 more source
A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"? [PDF]
With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The
Cannon, Paula M+14 more
core +2 more sources
Flow Cytometric Analysis of Calcium Influx Assay in T cells
Calcium influx is one of the key signaling events upon stimulation of T cell receptors (TCR) and plays an important role for T cell activation, proliferation, and differentiation.
Sun-Hwa Lee
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Herpes simplex virus type 1 (HSV-1), an α subgroup member of the human herpesvirus family, infects cells via the binding of its various envelope glycoproteins to cellular membrane receptors, one of which is herpes virus entry mediator (HVEM), expressed ...
Yang Gao+25 more
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