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Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial.

JAMA Psychiatry
Foley ÉM, Turner N, Margelyte R, Jones HJ, Kaser M, Lewis G, Jones PB, Khandaker GM.   +7 more
europepmc   +1 more source

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Single Nucleotide Polymorphism of Interleukin-18 and Interleukin-18 Receptor and the Risk of Papillary Thyroid Cancer

Experimental and Clinical Endocrinology & Diabetes, 2015
Growing evidence suggests that interleukin-18 (IL-18) levels may affect neoplasia and that single nucleotide polymorphisms (SNPs) within IL-18 gene may influence its production. In this study, we evaluated whether IL-18 and IL-18 receptor (IL-18R) polymorphisms are associated with the development and clinicopathological features of papillary thyroid ...
J H, Chung, Y C, Lee, Y G, Eun, J H, Chung, S K, Kim, S, Chon, S J, Oh, S Y, Rhee, I K, Hong   +8 more
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Expression of Interleukin‐18 and its Receptor in Mouse Ovary

American Journal of Reproductive Immunology, 2001
PROBLEM: Interleukin‐18 (IL‐18) strongly induces interferon‐gamma production and is produced not only by types of immune cells but also by types of non‐immune cells. Ovulation is thought to be an inflammation‐like reaction in which many pro‐inflammatory cytokines are involved. We investigated whether IL‐18 is involved in the functions of ovary.
 METHOD
YOSHIYUKI TSUJI, SUSUMU ADACHI, KOJI KOYAMA, TOMOKO HASHIMOTO TAMAOKI, ATSUKO IEMOTO, JUN‐ICHI FURUYAMA, TOMOKO HASHIMOTO TAMAOKI, AKIKO HASEGAWA, JUN‐ICHI FURUYAMA, KOJI KOYAMA, TOMOKO HASHIMOTO TAMAOKI, SHIN‐ICHIRO KASHIWAMURA, HARUYASU UEDA, JUNKO MURANAKA, JUN‐ICHI FURUYAMA, HARUKI OKAMURA   +15 more
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Heterogeneity of response of rheumatoid synovium cell subsets to interleukin‐18 in relation to differential interleukin‐18 receptor expression

Arthritis & Rheumatism, 2003
AbstractObjectiveTo examine the differential response of rheumatoid arthritis (RA) synovium cell subsets to interleukin‐18 (IL‐18), the effect of IL‐18 on Th1‐cytokine production, and the regulation of IL‐18 by IL‐18 binding protein (IL‐18BP).MethodsRA fibroblast‐like synoviocytes were stimulated with IL‐1β, IL‐12, and IL‐18, and levels of IL‐6 were ...
Masanori, Kawashima, Pierre, Miossec
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Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18

Journal of Interferon & Cytokine Research
Interleukin 18 (IL-18) is a key cytokine involved in the activation of T and NK cells, which are major effector cells in tumor killing. However, recombinant IL-18 showed limited efficacy in clinical trials. A recent study showed the lack of efficacy was largely due to the existence of IL-18BP, a soluble decoy receptor for IL-18.
Yasaman Mortazavi, Robert Herrera, Matthieu Masureel, Timurs Maculins, Isabelle Lehoux, Jonathan Sockolosky, Nathan West, Beyza Bulutoglu, Yue Zhao   +8 more
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Enhanced Expression of Interleukin-18 and its Receptor in Idiopathic Pulmonary Fibrosis

American Journal of Respiratory Cell and Molecular Biology, 2004
Abstract Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP) is a major interstitial lung disease (ILD). Recently, we established a new mouse model for ILD in which daily administration of interleukin (IL)-18 with IL-2 induces lethal lung injury, suggesting that IL-18 is involved in the pathogenesis of ILD.
Yasuhiko, Kitasato, Tomoaki, Hoshino, Masaki, Okamoto, Seiya, Kato, Yoshiro, Koda, Nobuhiko, Nagata, Masaharu, Kinoshita, Hideyuki, Koga, Do-Young, Yoon, Hironobu, Asao, Hiroshi, Ohmoto, Takeharu, Koga, Toru, Rikimaru, Hisamichi, Aizawa   +13 more
openaire   +2 more sources