Results 21 to 30 of about 1,144,647 (289)

Transient expression of interleukin 2 receptors. Consequences for T cell growth

Journal of Experimental Medicine, 1983
T lymphocyte mitosis results from the interaction of interleukin 2 (IL- 2) with specific receptors that appear only after appropriate immune stimulation. To assess the potential role of IL-2 receptor levels in determining the rate and magnitude of T cell
D. Cantrell, K. Smith
semanticscholar   +1 more source

Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein 180L Single-Nucleotide Polymorphism Is Associated With Susceptibility to Recurrent Pneumococcal Lower Respiratory Tract Infections in Children

Frontiers in Immunology, 2018
Lower respiratory tract infections (LRTI) are often caused by Streptococcus pneumoniae (Spn) and can be recurrent in 8% of children older than 2 years of age.
Johan N. Siebert, Johan N. Siebert, Lutz Hamann, Charlotte M. Verolet, Cécile Gameiro, Stéphane Grillet, Claire-Anne Siegrist, Claire-Anne Siegrist, Claire-Anne Siegrist, Klara M. Posfay-Barbe, Klara M. Posfay-Barbe   +10 more
doaj   +1 more source

Expression of interleukin 2 receptors on activated human B cells

Journal of Experimental Medicine, 1984
Using anti-Tac, a monoclonal anti-interleukin 2 (IL-2) receptor antibody, we have explored the possibility that certain activated B cells display receptors for IL-2.
T. Waldmann, C. Goldman, R. Robb, J. Depper, W. Leonard, S. Sharrow, K. Bongiovanni, S. Korsmeyer, W. Greene   +8 more
semanticscholar   +1 more source

Interleukin-2 Receptor Positive Cells and Circulating Soluble Interleukin-2 Receptors in Patients with Solid Tumors are not Correlated

The International Journal of Biological Markers, 1989
Activated lymphocytes can release a soluble form of IL-2 receptor (sIL-2R), which retains the capacity to bind IL-2. Abnormally high values of sIL-2R have been observed in patients with advanced solid tumors.
P. Lissoni, V. Rizzo, S. Barni, R. Rescaldani, F. Rovelli, A. Biondi, C. Archili, F. Frigerio, G. Tancini   +8 more
doaj   +1 more source

Activated B cells express receptors for, and proliferate in response to, pure interleukin 2

Journal of Experimental Medicine, 1984
In this study we investigated whether interleukin 2 (IL-2) acts on B cell proliferation and whether activated B cells express IL-2 receptors. First, the functional activity of immunoaffinity-purified or recombinant human IL-2 was studied in a B blast ...
R. Zubler, J. Lowenthal, F. Erard, N. Hashimoto, R. Devos, H. Macdonald   +5 more
semanticscholar   +1 more source

Structure-function relationships for the interleukin 2 receptor system

Memorias do Instituto Oswaldo Cruz, 1987
Receptors for interleukin 2 (IL-2) esit in at least three forms which differ in their subunit compositio, their affinity for ligand and their ability to mediate a cellular reponse.
Richard J. Robb
doaj   +1 more source

Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells

Journal of Experimental Medicine, 1985
Gamma interferon induced surface expression of interleukin 2 (IL-2) receptors on normal human monocytes and the monocytoid cell lines U937 and HL60. These receptors were detected by anti-IL-2 receptor monoclonal antibodies, and U937 IL-2 receptors were ...
F. Herrmann, S. Cannistra, H. Levine, J. Griffin   +3 more
semanticscholar   +1 more source

The interleukin-2 receptor.

Journal of Biological Chemistry, 1991
The interleukins comprise a class of hormones that have a definite known secondary and tertiary structure under physiologic conditions. The interleukin-2 is the leader in T cell differentiation. The interleukin-2 acts via interaction with high affinity, cell bound receptors (IL-2R). High affinity IL-2 receptors are constructed by cooperative binding of
P, Marino, A, Preatoni
openaire   +4 more sources

Targeted Activation of T Cells with IL-2-Coupled Nanoparticles

Cells, 2020
Interleukin-2 (IL-2) is a T cell growth factor particularly required in regulatory T cell maintenance and memory T cell responses. High-dose IL-2 treatment was the first FDA-approved immunotherapy for cancer, while low-dose IL-2 administration has shown ...
Verena K. Raker, Christian Becker, Katharina Landfester, Kerstin Steinbrink   +3 more
doaj   +1 more source

Evidence for Monocyte Reprogramming in a Long-Term Postsepsis Study

Critical Care Explorations, 2022
OBJECTIVES:. This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers.
Raquel Bragante Gritte, PhD, Talita Souza-Siqueira, PhD, Eliane Borges da Silva, PhD, Laiane Cristina dos Santos de Oliveira, PhD, Rodrigo Cerqueira Borges, PhD, Heloísa H de Oliveira Alves, PhD, Laureane Nunes Masi, PhD, Gilson Masahiro Murata, PhD, Renata Gorjão, PhD, Adriana Cristina Levada-Pires, PhD, Antônio Carlos Nogueira, PhD, Tânia Cristina Pithon-Curi, PhD, Ricardo Bentes de Azevedo, PhD, Francisco Garcia Soriano, MD, PhD, Rui Curi, PhD, Marcel Cerqueira Cesar Machado, MD, PhD   +15 more
doaj   +1 more source