Results 261 to 270 of about 61,846,700 (305)

Interleukin-21 rs2055979 and Interleukin-21 receptor rs3093390 genetic variants and hepatitis C virus chronic infection.

Gastroenterology and hepatology from bed to bench, 2017
The aim of this case-control study was to investigate association of G/T IL-21 (rs2055979) and C/T IL-21R (rs3093390) gene polymorphisms with chronic hepatitis C virus in Iranian Patients.Interleukin 21 (IL-21) has a significant function in the regulation of cellular immune responses. Its exclusive receptor, IL-21R, expressed on the surface of T, B and
Shoraka, Shahrzad, Mohebbi, Seyed Reza, Hosseini, Seyed Masoud, Razavi, Armin Hosseini, Ghaemi, Amir, Kazemian, Shabnam, Rostami-Nejad, Mohammad   +6 more
openaire   +2 more sources

Interleukin‐21 receptor gene polymorphism (rs2285452 A/G) is associated with susceptibility to Behçet's disease

International Journal of Immunogenetics, 2023
AbstractBehçet's disease (BD) is a chronic auto inflammatory disorder of unknown aetiology. Recently, the dysregulation of interleukin‐21 receptor (IL‐21R) has been incriminated in different autoimmune and auto‐inflammatory diseases, such as systemic lupus erythematous, rheumatoid arthritis, and type 1 diabetes.
Rajaa Lahmar, Elyes Chabchoub, Ramzi Zemni, Mzabi Anis, Neirouz Ghannouchi, Foued Ben Hadj Slama   +5 more
openaire   +2 more sources

The crystal structure of the interleukin 21 receptor bound to interleukin 21 reveals that a sugar chain interacting with the WSXWS motif is an integral part of the interleukin 21 receptor

2012
Interleukin (IL) 21 is a class I cytokine, which exerts pleiotropic effects on both innate and adaptive immune responses. It signals through a heterodimeric receptor complex consisting of the IL-21 receptor (IL-21R) and the common gamma chain (gC). A hallmark of the class I cytokine receptors is the class I cytokine receptor signature motif (WSXWS ...
Hamming, Ole Jensen, Kang, Lishan, Svensson, Anders, Karlsen, Jesper Lykkegaard; id_orcid 0000-0002-3146-2414, Rahbek-Nielsen, Henrik, Paludan, Søren Riis, Hjorth, Siv A, Bondensgaard, Kent, Hartmann, Rune   +8 more
openaire   +1 more source

Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2

Biochemical and Biophysical Research Communications, 2010
Interleukin-21 (IL-21) is a pleiotropic cytokine that regulates T-cell, B-cell, NK-cell, and myeloid-cell functions. IL-21 binds with its cognate receptor complex, which consists of the IL-21 receptor (IL-21R) and the common gamma chain (gammac) receptor subunit.
Hidetoshi, Nara, Tadashi, Onoda, Mizanur, Rahman, Akemi, Araki, Farha M, Juliana, Nobuyuki, Tanaka, Hironobu, Asao   +6 more
openaire   +2 more sources

Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus

International Journal of Molecular Medicine, 2005
Interleukin-21 (IL-21) is the most recent member of the common gamma-chain-dependent cytokine family. We studied the expression of the IL-21 receptor (IL-21R) on peripheral B lymphocytes in patients with systemic lupus erythematosus (SLE) or primary Sjögren's syndrome (pSjS), and healthy controls.
Hiroki, Mitoma, Takahiko, Horiuchi, Yasutaka, Kimoto, Hiroshi, Tsukamoto, Ayumi, Uchino, Yasuhiro, Tamimoto, Yugo, Miyagi, Mine, Harada   +7 more
openaire   +2 more sources

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

Nature, 2000
Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here we have identified a class I cytokine receptor that is selectively expressed in lymphoid tissues and is capable of signal transduction.
J, Parrish-Novak, S R, Dillon, A, Nelson, A, Hammond, C, Sprecher, J A, Gross, J, Johnston, K, Madden, W, Xu, J, West, S, Schrader, S, Burkhead, M, Heipel, C, Brandt, J L, Kuijper, J, Kramer, D, Conklin, S R, Presnell, J, Berry, F, Shiota, S, Bort, K, Hambly, S, Mudri, C, Clegg, M, Moore, F J, Grant, C, Lofton-Day, T, Gilbert, F, Rayond, A, Ching, L, Yao, D, Smith, P, Webster, T, Whitmore, M, Maurer, K, Kaushansky, R D, Holly, D, Foster   +37 more
openaire   +2 more sources

Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses

Journal of Leukocyte Biology, 2002
AbstractInterleukin (IL)-21 was recently discovered using a functional cloning approach based on expression of its receptor. It is similar in domain organization and primary sequence to IL-2 and IL-15. Like these cytokines, IL-21 uses the common γ chain of the IL-2/15 receptor, which forms a heterodimeric receptor complex with IL-21R. IL-21 is produced
Julia, Parrish-Novak, Donald C, Foster, Richard D, Holly, Christopher H, Clegg   +3 more
openaire   +2 more sources

Association between Interleukin-21 and Interleukin-21 receptor gene polymorphisms with susceptibility to chronic hepatitis B virus infection and HBV spontaneous clearance in Iranian population

Microbial Pathogenesis, 2019
Hepatitis B virus (HBV) infection is a major public health concern due to the infection often leads to chronic infection, liver cirrhosis and also liver cancer. The host immune response to HBV infection and also genetic background play significant role in outcome of infection.
Shahrzad, Shoraka, Seyed Reza, Mohebbi, Seyed Masoud, Hosseini, Armin, Hosseini Razavi, Yasin, Hatami, Afsaneh, Sharifian, Mohammad, Rostami-Nejad, Hamid, Asadzadeh Aghdaei, Mohammad Reza, Zali   +8 more
openaire   +2 more sources

Abstract W P218: Interleukin 21 receptor: A Major Modulator of Infarct Volume

Stroke, 2014
Using the permanent middle cerebral artery occlusion (MCAO) model of stroke, we have demonstrated that different inbred mouse strains show profound differences in infarct volume, indicating that infarction is under strong genetic control. To identify natural genetic determinants modulating infarction, we employed quantitative trait locus (QTL) linkage ...
Han Kyu Lee, Sehoon Keum, Donald C Lo, Douglas A Marchuk   +3 more
openaire   +1 more source

Interleukin-21 Receptor Might be a Novel Therapeutic Target for the Treatment of Rheumatoid Arthritis

Journal of Experimental & Clinical Medicine, 2014
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the synovial inflammation of the joints. Various cells and cytokines have been identified that may contribute to RA pathology. Interleukin (IL)-21 is a proinflammatory cytokine mediating pleiotropic functions through the IL-21 receptor (IL-21R).
Farhad Seif, Majid Khoshmirsafa, Mohammad Mousavi, Pezhman Beshkar, Mahmoud Rafeian-Kopaei, Nader Bagheri, Hedayatollah Shirzad   +6 more
openaire   +1 more source