Results 261 to 270 of about 19,088,710 (306)

Evidence for a Low-Affinity Interleukin-3 Receptor

Growth Factors, 1990
Interleukin-3 (IL-3) regulates the proliferation of myeloid, erythroid, and lymphoid cells. Previous reports showed IL-3 binding restricted to a single high-affinity (Kd = 50-200 pM) site. Here, we demonstrate by equilibrium studies an additional binding site for IL-3 with lower apparent affinity (Kd = 5-20 nM). Furthermore, kinetic analysis shows that
J, Schreurs, K, Arai, A, Miyajima
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Affinity isolation of the interleukin-3 surface receptor

Biochemical and Biophysical Research Communications, 1986
Interleukin-3 (IL-3) is a pluripotent hematopoietic growth factor which can stimulate both proliferation and differentiation of progenitor cells. Using the factor dependent NSF-60 and FDC-P1 cells, which possess specific, high affinity binding sites for 125I-IL-3 (i.e.
W S, May, J N, Ihle
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Functional Interaction of c-Kit Receptor and Interleukin-3 Receptor.

Blood, 2007
Abstract Hematopoiesis is regulated by a number of growth factors and cytokines, among which stem cell factor (SCF) plays a critical role for normal hematopoiesis. An important feature of SCF is its strong capacity to synergize with the cytokines including interleukin-3(IL-3), granulocyte-marcrophage colony-stimulation factor (GM-CSF ...
Sherman M. Weissman, Zhijia Ye
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Receptors for Interleukin-3 (IL-3)

1995
Abstract The murine and human IL-3R o. subunit cDNAs (GenBank accession numbers X64534 and M74782) encode a protein of 396 and 378 amino acids including a putative signal peptide of 16 and 18 amino acids, an extracellular domain of 315 and 288 amino acids, a single transmembrane spanning segment of 24 and 20 amino acids, and a ...
T Ogorochi, A Miyajima
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Properties of the Murine Interleukin-3 Receptor

1990
Murine interleukin-3 (mIL-3) is a hemopoietic growth factor produced by activated T lymphocytes that stimulates the survival, proliferation and differentiation of pluripotent stem cells and a variety of committed myeloid and lymphoid progenitors (1). Because of its wide range of biological activities both in vitro and in vivo (2), it is thought to play
A. L.-F. Mui, P. H. B. Sorensen, S. C. Murthy, G. Krystal   +3 more
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Cloning of an Interleukin-3 Receptor Gene: a Member of a Distinct Receptor Gene Family

Science, 1990
Interleukin-3 (IL-3) binds to its receptor with high and low affinities, induces tyrosine phosphorylation, an d promotes the proliferation and differentiation of hematopoietic cells. A binding component of the IL-3 receptor was cloned. Fibroblasts transfected with the complementary DNA bound IL-3 with a low affinity [dissociation constant (
N, Itoh, S, Yonehara, J, Schreurs, D M, Gorman, K, Maruyama, A, Ishii, I, Yahara, K, Arai, A, Miyajima   +8 more
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Characterization of the interleukin 3 receptor.

Experimental hematology, 1990
A variety of homobifunctional crosslinking agents have been used to gain insight into the nature of the murine interleukin 3 (mIL-3) receptor. When [125I]mIL-3 was cross-linked to receptor sites on the surfaces of intact B6SUtA1 cells with disuccinimidyl suberate (DSS), sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) revealed the ...
S C, Murthy, A L, Mui, G, Krystal
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CD123 (Interleukin 3 receptor a chain).

2001
CD 123 is the interleukin 3 receptor alpha chain and is expressed on different type of myloid hematopoietic ...
Moretti S., LANZA, Francesco, Dabusti M., Tieghi A., CAMPIONI, Diana, Dominici M., Castoldi GL   +6 more
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CD123 (interleukin 3 receptor alpha chain).

Journal of biological regulators and homeostatic agents, 2001
not ...
S. MORETTI, F. LANZA, M. DABUSTI, A. TIEGHI, D. CAMPIONI, DOMINICI, Massimo, G. L. CASTOLDI   +6 more
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Interleukin-3-associated ganglioside GD1a is induced independently of normal interleukin-3 receptor in murine myelogenous leukaemia NFS60 cells transfected with the interleukin-3 gene

Glycoconjugate Journal, 1996
The mechanism of interleukin-3 (IL-3) independent cell growth and of IL-3-associated ganglioside expression was analysed using the IL-3 dependent murine myelogenous leukaemia cell line NFS60-I7 and IL-3 gene-transfected sublines. The transfected cell lines showed autonomous cell growth, tumorigenicity, and IL-3 associated ganglioside GD1a expression in
M, Nakamura, K, Kirito, A, Tsunoda, K, Hara, Y, Furukawa, M, Saito   +5 more
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