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The expression of functional erythropoietin receptors on an interleukin-3 dependent cell line
Biochemical and Biophysical Research Communications, 1987We report the expression of the erythropoietin receptors on an interleukin-3 dependent cell line. By the transfer into medium supplemented with erythropoietin, DA-1 cells were converted to an erythropoietin dependent growth state. [125I] erythropoietin was used to detect receptors specific for this hormone on the cell surface.
M, Sakaguchi +6 more
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Interleukin-3 receptor as a target for antileukemic drugs
Drugs of the Future, 2004interieukin-3 (IL-3) is the prototype of a pieiotropic cylokine displaying a key cole in the control of the proliferation, survival and differerdiation of hematopoietic cells. This cytokine acts via a membrane receptor comprised of an α-chain (IL-3Hα) specific to this receptor and a β-chain (IL-3Rβ) common to IL-3.
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Demonstration of interleukin‐3 receptor‐associated antigen in the central nervous system
Journal of Neuroscience Research, 1995AbstractWe previously reported that interleukin‐3 (IL‐3) acts as a neurotrophic factor for cholinergic neurons. However, it has not yet been determined whether the action is derived from the interaction of IL‐3 with IL‐3 receptors. As the first step to study IL‐3 receptors in the central nervous system, we examined the presence and localization of IL‐3
Y, Konishi +5 more
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Regulation of Expression of the Interleukin-2 Receptor on Hematopoietic Cells by Interleukin-3
Science, 1986Remarkable similarities in the intracellular and genetic events occur when lymphoid and hematopoietic cells are exposed to their specific growth factors. The interleukin-2 (IL-2) receptor, whose cell-surface expression is an absolute requirement for the growth and differentiation of lymphoid cells, was detected on various nonlymphoid ...
M C, Birchenall-Sparks +4 more
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2009
Murine interleukin-3 (mIL-3) is a potent hemopoietic growth factor that is produced primarily by activated T lymphocytes and stimulates the proliferation and differentiation of pluripotent stem cells and committed myeloid and early lymphoid progenitors.
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Murine interleukin-3 (mIL-3) is a potent hemopoietic growth factor that is produced primarily by activated T lymphocytes and stimulates the proliferation and differentiation of pluripotent stem cells and committed myeloid and early lymphoid progenitors.
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Molecular Characterization of the Mouse Interleukin-3 Receptor
1992erythroblasts, eosinophils, megakaryocytes, mast cells, and pro-B cells [1]. Whereas IL-3 is capable of regulating proliferation and differentiation of various hemopoietic cell lineages, production of IL-3 is limited to antigen-stimulated T cells and activated mast cells and so far there is no evidence indicating that IL-3 is produced in normal bone ...
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Experimental hematology, 1992
Two receptor polypeptides have been identified in several studies by using cross-linking with interleukin 3 (IL-3). It has been suggested that proteolytic degradation of the larger polypeptide yields the lower molecular weight fragment, but there is little proof that this is the case.
V, Duronio +2 more
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Two receptor polypeptides have been identified in several studies by using cross-linking with interleukin 3 (IL-3). It has been suggested that proteolytic degradation of the larger polypeptide yields the lower molecular weight fragment, but there is little proof that this is the case.
V, Duronio +2 more
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2010
Hemopoiesis is regulated, in part, by a group of potent, soluble hemopoietic growth factors. One of these growth factors, interleukin 3, stimulates the proliferation and differentiation of both multi-potential hemopoietic stem cells and maturing committed progenitors, and may thus play a central role in regulating hemopoiesis in vivo.
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Hemopoiesis is regulated, in part, by a group of potent, soluble hemopoietic growth factors. One of these growth factors, interleukin 3, stimulates the proliferation and differentiation of both multi-potential hemopoietic stem cells and maturing committed progenitors, and may thus play a central role in regulating hemopoiesis in vivo.
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Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease
Circulation Research, 2021exaly