Results 51 to 60 of about 19,088,710 (306)

Molecular Mechanism of NLRP3 Inflammasome in Inflammatory Diseases and Tumors

Immunity, Inflammation and Disease
The nucleotide‐binding and oligomerization domain‐like receptors (NLRs) are pattern recognition receptors. Nucleotide‐binding oligomerization domain‐like receptor family pyrin domain‐containing 3 (NLRP3), a member of the NLRs family, can form a protein ...
Le‐Lan Gong, He‐Jiang Zhou, Quan‐Ming Zhao, Ning Xu, Feng‐Chang Huang, Ling‐Yan Su, Wen‐Liang Li   +6 more
doaj   +1 more source

Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients

Scientific Reports, 2021
The role of innate immunity in COVID-19 is not completely understood. Therefore, this study explored the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection on the expression of Pattern Recognition Receptors (PRRs) in ...
Maria Clara Saad Menezes, Alicia Dudy Müller Veiga, Thais Martins de Lima, Suely Kunimi Kubo Ariga, Hermes Vieira Barbeiro, Claudia de Lucena Moreira, Agnes Araujo Sardinha Pinto, Rodrigo Antonio Brandao, Julio Flavio Marchini, Julio Cesar Alencar, Lucas Oliveira Marino, Luz Marina Gomez, Niels Olsen Saraiva Camara, Heraldo P. Souza   +13 more
doaj   +1 more source

IL3RA (interleukin-3 receptor alpha) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on IL3RA (interleukin-3 receptor alpha), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source

Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor [PDF]

, 2011
Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen.
Saralili Dipa Robertson, Sofat, N, Nidhi Sofat, Wait, R, Robertson, SD, Wait, Robin, Robin Wait   +6 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Simvastatin and Recombinant Antagonist of Receptors of Interleukin-1 Modulate Toll-like Receptors in Experimental Acute Ileitis in Rat

Research in Molecular Medicine, 2014
Background: The pathogenesis of inflammatory bowel disease is complex and multifactorial. Studies have led to the current concept that Toll-like receptors represent key mediators of innate host defense in the intestine, and they are involved in ...
Aleksandr Zherebiatiev, Aleksandr Kamyshnyi   +1 more
doaj  

Enhancement of CAR‐T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins

Cancer Communications, 2023
Background Existing treatments for cholangiocarcinoma have poor efficacy. However, chimeric antigen receptor‐T (CAR‐T) cells are emerging as a potential therapeutic strategy.
Yidan Qiao, Jie Chen, Xuemei Wang, Shumei Yan, Jizhou Tan, Baijin Xia, Yongjian Chen, Keming Lin, Fan Zou, Bingfeng Liu, Xin He, Yiwen Zhang, Xu Zhang, Hui Zhang, Xiangyuan Wu, Lijuan Lu   +15 more
doaj   +1 more source

Priming by recombinant chicken interleukin-2 induces selective expression of IL-8 and IL-18 mRNA in chicken heterophils during receptor-mediated phagocytosis of opsonized and nonopsonized Salmonella enterica serovar enteritidis [PDF]

, 2003
Heterophils, the principal avian polymorphonuclear leukocytes (PMNs) equivalent to the mammalian neutrophil, function as professional phagocytes against bacterial infections, mediate acute inflammation, and respond to cytokine stimulation to aid in ...
Michael H Kogut, Pete Kaiser, Kogut, Michael H, Kaiser, Pete, Lisa Rothwell, Rothwell, Lisa   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mouse bone marrow-derived mast cells acquire responsiveness to substance P after co-culture with 3T3 fibroblasts in the presence of stem cell factor

Allergology International, 1998
Connective tissue-type mast cells degranulate in response to a neurogenic peptide, substance P, whereas bone marrow-derived mast cells (BMMC) do not respond to this stimulant when prepared with a combination of interleukin-3 and interleukin-4.
Eishin Morita, Takaaki Hiragun, Toshihiko Tanaka, Yoshikazu Kameyoshi, Tsutomu Okabe, Michihiro Hide, Shoso Yamamoto   +6 more
doaj   +1 more source