Results 61 to 70 of about 19,088,710 (306)

Suppressible and nonsuppressible autocrine mast cell tumors are distinguished by insertion of an endogenous retroviral element (IAP) into the interleukin 3 gene [PDF]

, 1993
After v-H-ras expression, the interleukin 3 (IL-3)-dependent PB-3c mast cells progress in vivo to two different classes of IL-3 autocrine tumors. Class I tumors show a germline configuration of the IL-3 gene and represent more than 90% of tumors analyzed
Nair, A. P., Hirsch, H. H., A P Nair, Moroni, C., C Moroni, H H Hirsch   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Post-transcriptional effects of interleukin-3, interferon-gamma, erythropoietin and butyrate on in vitro hemoglobin chain synthesis in congenital hemolytic anemia

Haematologica, 2001
BACKGROUND AND OBJECTIVES: Various agents modulate hemoglobin synthesis. In vitro modulation of translation in hemoglobin chain synthesis was analysed in patients with congenital hemolytic anemia (n=32) and healthy controls (n=17).
D Reinhardt, R Ridder, W Kugler, A Pekrun   +3 more
doaj  

Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]

, 2011
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli, Khader Valli Rupanagudi, Allam, R., Anders Hans-Joachim, Darisipudi, M.N., Ramanjaneyulu Allam, Allam Ramanjaneyulu, Murthy Narayana Darisipudi, Hans-Joachim Anders, Rupanagudi, K.V., Rupanagudi, Khader Valli, Anders, Hans-Joachim, Anders, H.J., Darisipudi, Murthy Narayana, Darisipudi Murthy Narayana, Allam, Ramanjaneyulu   +15 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Granulocyte and granulocyte-macrophage colony-stimulating factors, their receptors and interleukin-3 levels in newborns

The Turkish Journal of Pediatrics, 1997
Serum levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and interleukin-3 (IL-3) as well as neutrophil counts were studied on the first, second and fifth days after birth, in order ...
M Coşkun, F Kardelen, N Oygür, L Undar, A Savaş, O Yeğin   +5 more
doaj  

The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A₃ Receptor Agonist, in a Rat Model of Colitis

Cells, 2020
The pharmacological activation of A3 receptors has shown potential usefulness in the management of bowel inflammation. However, the role of these receptors in the control of visceral hypersensitivity in the presence of intestinal inflammation has not ...
Luca Antonioli, Elena Lucarini, Catia Lambertucci, Matteo Fornai, Carolina Pellegrini, Laura Benvenuti, Lorenzo Di Cesare Mannelli, Andrea Spinaci, Gabriella Marucci, Corrado Blandizzi, Carla Ghelardini, Rosaria Volpini, Diego Dal Ben   +12 more
doaj   +1 more source

Structure of the IL-27 quaternary receptor signaling complex

eLife, 2022
Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis.
Nathanael A Caveney, Caleb R Glassman, Kevin M Jude, Naotaka Tsutsumi, K Christopher Garcia   +4 more
doaj   +1 more source

Binding of src-like Kinases to the β-Subunit of the Interleukin-3 Receptor [PDF]

Journal of Biological Chemistry, 1997
We have previously shown that stimulation of 32D cl3 cells with interleukin (IL)-3 results in the activation of three src-like tyrosine kinases, fyn, hck, and lyn. The beta subunit of the IL-3 receptor co-immunoprecipitated with hck in lysates of both unstimulated and IL-3-stimulated cells; however, the beta subunit did not precipitate with either fyn ...
E A, Burton, S, Hunter, S C, Wu, S M, Anderson   +3 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source