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A soluble form of the interleukin 4 receptor in biological fluids
Cytokine, 1990Murine biological fluids and murine cell culture supernatants were analyzed for the presence of soluble murine interleukin 4 receptor (sIL4R) with the use of two monoclonal antibodies directed against the receptor. Mouse urine, serum, ascitic fluid, and cell culture supernatants contained varying levels of immunoreactive protein.
W C, Fanslow +5 more
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Structure and function of interleukin-4 and its receptor
1995Interleukin-4 (IL-4) is a highly pleiotropic cytokine which has been extensively studied in the last decade. It is predominantly produced by activated T lymphocytes, mast cells, and basophils [1–5]. Consistent with the pleiotropic nature of this molecule, the receptors for IL-4 have been identified on many different cell types, including hematopoietic ...
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Interleukin-4 receptors on human blood mononuclear cells
Cellular Immunology, 1990We have studied regulation of the expression of the interleukin-4 receptor (IL-4R) on human blood mononuclear cells (PBMC) using both 125I-IL-4 binding assay and flow cytometric analysis of biotinylated IL-4 (B-IL-4) binding. PBMC express approximately 300 high-affinity IL-4R per cell (Kd = 25-100 pM).
C E, Zuber +4 more
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An update on interleukin-4 and its receptor.
European cytokine network, 1998Interleukin-4 (IL-4) exhibits many biological and immunoregulatory functions on B lymphocytes, monocytes, dendritic cells and fibroblasts. The IL-4 gene is located on chromosome 5 and displays several cell-specific regulatory sequences in its promoter, which explain its restricted secretion pattern to activated T cells and mast cells. The IL-4 receptor
P, Chomarat, J, Banchereau
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[Atopy and interleukin-4 receptor].
Rinsho byori. The Japanese journal of clinical pathology, 1999Both IL-4 and IL-13 induce IgE synthesis in B cells by binding to their functional receptors on target cells. These receptors are considered to be composed of heterodimers and both share the IL-4R alpha chain (IL-4R alpha) as a component. Atopy is an inherited tendency, underlying asthma, rhinitis and eczema, and generating high nonspecific IgE and/or ...
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Interleukin-4 Receptor Signalling Mechanisms and Their Biological Significance
1998These studies describe key elements of the means through which the IL-4 receptor transduces functions of IL-4 and show relationships between these biochemical events and the major biological consequences of IL-4 action. In large measure, the control of IL-4-mediated growth and gene activation are segregated to different regions of the cytosolic domain ...
K, Nelms +4 more
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Interleukin-4 receptor signaling pathways in asthma pathogenesis
Trends in Molecular Medicine, 2004Asthma is a chronic allergic inflammatory disease, the initiation and progression of which is dependent on the cytokines interleukin (IL)-4 and IL-13 acting through related receptor complexes. Disease pathogenesis is effected by intracellular signaling pathways that couple primarily to specific motifs within the intracellular domain of the IL-4 ...
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Therapeutic Targeting of the Interleukin-4/Interleukin-13 Signaling Pathway: In Allergy and Beyond
BioDrugs, 2018D. Karo-Atar +3 more
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Expression of interleukin-4 and interleukin-13 and their receptors in colorectal cancer
International Journal of Colorectal Disease, 2012A. Formentini +5 more
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Interleukin-4 and its receptor: Essentialmediators of the allergic response
Journal of Allergy and Clinical Immunology, 1997Editor's Note: This is the first of a series of concise reviews intended to update clinicians on new and relevant developments in cellular and molecular immunology. They are presented by the Mechanisms of Allergy interest section of the AAAAI. The guest editorial committee is composed of David M. Essayan, MD, Baltimore, Md.; Charity C.
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