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Anti-Inflammatory Interleukins in the Pathogenesis of Atherosclerosis. [PDF]
Int J Mol SciGujytė G +5 more
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Acquired perforating dermatosis associated with uremic pruritus treated with dupilumab monotherapy: A case report. [PDF]
JAAD Case RepMubarak S +4 more
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Regulation of interleukin 4 receptors on human T cells
International Immunology, 1990Human recombinant interleukin 4 (IL-4) was modified with biotin-N-hydroxysuccinimide and used to examine the expression of human IL-4 receptors (IL-4R) on activated peripheral blood T cells by flow cytometry. Freshly isolated T cells expressed only a low level of IL-4R which remained unchanged when cells were cultured in the absence of stimuli.
R J, Armitage +4 more
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A model of the complex between interleukin‐4 and its receptors
Proteins: Structure, Function, and Bioinformatics, 1995AbstractA three‐dimensional model of interleukin‐4 (IL‐4) bound to one molecule each of the high‐ and low‐affinity receptors (IL‐4R and IL‐2Rγ) was built, using the crystal structure of the complex of human growth hormone (HGH) with its receptor (HGHR) as a starting model.
A, Gustchina +3 more
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The Journal of Pharmacology and Experimental Therapeutics, 1996
Soluble interleukin-4 (IL-4) receptors (sIL-4R) can have either enhancing or inhibitory effects on the activity of IL-4 in vivo, depending on the relative concentration ratios of sIL-4R to IL-4. Whereas competition with membrane IL-4 receptors is the basis for their inhibitory action, the mechanisms responsible for the potentiation of IL-4 activity are
Y, Ma, H E, Hurst, R, Fernandez-Botran
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Soluble interleukin-4 (IL-4) receptors (sIL-4R) can have either enhancing or inhibitory effects on the activity of IL-4 in vivo, depending on the relative concentration ratios of sIL-4R to IL-4. Whereas competition with membrane IL-4 receptors is the basis for their inhibitory action, the mechanisms responsible for the potentiation of IL-4 activity are
Y, Ma, H E, Hurst, R, Fernandez-Botran
openaire +3 more sources
Interleukin‐4 and the interleukin‐4 receptor in allergic contact dermatitis
Contact Dermatitis, 1998Cutaneous immune responses involving T helper (TH) type 1 (TH1) and type 2 (TH2) T cells, characterised by secretion of interferon‐γ (Ifn‐γ) and interleukin‐4 (IL‐4), respectively, have both been reported in allergic contact dermatitis (ACD). We used immunohistochemistry to localize expression of IL‐4 in ACD lesions and unaffected skin.
A, Rowe, C B, Bunker
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Interleukin-4 and interleukin-13 as possible therapeutic targets in systemic sclerosis.
Cytokine, 2019Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal organs. Its pathogenesis, which is still poorly understood, features three main pathogenic moments: an initial diffuse vasculopathy followed by low-grade ...
G. Gasparini, E. Cozzani, A. Parodi
semanticscholar +1 more source
Interleukin 4 receptor: signaling mechanisms
Immunology Today, 1994Achsah Keegan and colleagues consider the signaling mechanisms utilized by the interleukin 4 (IL-4) receptor and review evidence suggesting that these mechanisms can account for the known responses of hematopoietic and non-hematopoietic cells to IL-4. Most of these data have been obtained from analyses of the ability of IL-4 to regulate the growth of ...
A D, Keegan +4 more
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Interleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy
Clinical Science, 1999Minimal change nephropathy (MCN) is an important cause of nephrotic syndrome, especially in children, that is strongly associated with atopy and IgE production. The immunogenetics of MCN are poorly understood. Interleukin-4 (IL-4) is the critical cytokine involved in the development of atopy.
Gillespie, KM +4 more
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