Results 261 to 270 of about 99,631,586 (306)
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Immunological Investigations, 2013
The aim of this study was to determine whether the functional interleukin-4 (IL-4) -590 C/T, IL-4 receptor (IL-4R) 1902 G/A, IL-18 -607 C/A, and -137 G/C polymorphisms polymorphisms confer susceptibility to rheumatoid arthritis (RA).Meta-analysis was conducted on the associations between these IL-4, IL-4R, and IL-18 polymorphisms and RA.A total of 12 ...
Gwan Gyu, Song +3 more
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The aim of this study was to determine whether the functional interleukin-4 (IL-4) -590 C/T, IL-4 receptor (IL-4R) 1902 G/A, IL-18 -607 C/A, and -137 G/C polymorphisms polymorphisms confer susceptibility to rheumatoid arthritis (RA).Meta-analysis was conducted on the associations between these IL-4, IL-4R, and IL-18 polymorphisms and RA.A total of 12 ...
Gwan Gyu, Song +3 more
openaire +2 more sources
Structure and function of interleukin-4 and its receptor
1995Interleukin-4 (IL-4) is a highly pleiotropic cytokine which has been extensively studied in the last decade. It is predominantly produced by activated T lymphocytes, mast cells, and basophils [1–5]. Consistent with the pleiotropic nature of this molecule, the receptors for IL-4 have been identified on many different cell types, including hematopoietic ...
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Interleukin-4 andInterleukin-4 Receptor AlphaGene Polymorphisms in Recurrent Aphthous Stomatitis
Immunological Investigations, 2018Recurrent aphthous stomatitis (RAS) is a common oral condition with a major impact on the quality of life. The condition is thought to be due to the overexpression of T helper-1(Th1)-related cytokines. Since interleukin-4 (IL-4) and its receptor (IL-4Rα) are antagonistic to Th-1 pathways, polymorphisms in their genes may also be involved in the ...
Shamsolmoulouk Najafi +6 more
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An update on interleukin-4 and its receptor.
European cytokine network, 1998Interleukin-4 (IL-4) exhibits many biological and immunoregulatory functions on B lymphocytes, monocytes, dendritic cells and fibroblasts. The IL-4 gene is located on chromosome 5 and displays several cell-specific regulatory sequences in its promoter, which explain its restricted secretion pattern to activated T cells and mast cells. The IL-4 receptor
P, Chomarat, J, Banchereau
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[Atopy and interleukin-4 receptor].
Rinsho byori. The Japanese journal of clinical pathology, 1999Both IL-4 and IL-13 induce IgE synthesis in B cells by binding to their functional receptors on target cells. These receptors are considered to be composed of heterodimers and both share the IL-4R alpha chain (IL-4R alpha) as a component. Atopy is an inherited tendency, underlying asthma, rhinitis and eczema, and generating high nonspecific IgE and/or ...
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Interleukins in Cancer: From Biology to Therapy
Nature Reviews Cancer, 2021Peter Libby +2 more
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Cellular Sources and Immune Functions of Interleukin-9
Nature Reviews Immunology, 2010Randolph Noelle
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Treating Inflammation by Blocking Interleukin-1 in a Broad Spectrum of Diseases
Nature Reviews Drug Discovery, 2012Jos WM van der Meer +2 more
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Interleukin-21: A Double-Edged Sword With Therapeutic Potential
Nature Reviews Drug Discovery, 2014Warren J Leonard, Rosanne Spolski
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