Results 251 to 260 of about 99,631,586 (306)

Interleukin 4 receptor: signaling mechanisms

Immunology Today, 1994
Achsah Keegan and colleagues consider the signaling mechanisms utilized by the interleukin 4 (IL-4) receptor and review evidence suggesting that these mechanisms can account for the known responses of hematopoietic and non-hematopoietic cells to IL-4. Most of these data have been obtained from analyses of the ability of IL-4 to regulate the growth of ...
A D, Keegan, K, Nelms, L M, Wang, J H, Pierce, W E, Paul   +4 more
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Interleukin-4 and interleukin-4 receptor polymorphisms in minimal change nephropathy

Clinical Science, 1999
Minimal change nephropathy (MCN) is an important cause of nephrotic syndrome, especially in children, that is strongly associated with atopy and IgE production. The immunogenetics of MCN are poorly understood. Interleukin-4 (IL-4) is the critical cytokine involved in the development of atopy.
Gillespie, KM, Parnham, A, Clark, AGB, Mathieson, PW, Parry, RG   +4 more
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Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk

European Journal of Cancer, 2007
Interleukin-4 (IL-4) and interleukin-4 receptor (IL-4R) modulate inflammation and are associated with the colorectal adenoma-carcinoma progression and the metastatic capacity. IL-4 also causes a dose-dependent reduction of proliferation in colorectal cancer cells.
LANDI, STEFANO, BOTTARI F, GEMIGNANI, FEDERICA, GIOIA PATRICOLA L, GUINO E, OSORIO A, DE OCA J, CAPELLA G, CANZIAN F, MORENO V.   +9 more
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The rat interleukin 4 receptor: coevolution of ligand and receptor

Cytokine, 1995
A rat interleukin 4 receptor (IL-4R) cDNA was cloned by polymerase chain reaction (PCR) using RNA of Con A activated T cells and primers deduced from mouse and human IL-4R sequences. Sequence analysis revealed an open reading frame for a putative membrane protein of 800 amino acids in length.
G, Richter, G, Hein, T, Blankenstein, T, Diamantstein   +3 more
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The interleukin-4 receptor: signal transduction by a hematopoietin receptor

Journal of Leukocyte Biology, 1994
Abstract Over the last several years, the receptors for numerous cytokines have been molecularly characterized. Analysis of their amino acid sequences shows that some of these receptors bear certain motifs in their extracellular domains that define a family of receptors called the Hematopoietin receptor superfamily [1–3].
A D, Keegan, J H, Pierce
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A computer model of the interleukin‐4/receptor complex

Proteins: Structure, Function, and Bioinformatics, 1993
AbstractInterleukin‐4 is a member of the cytokine family, a group of related messenger proteins which collectively help to moderate and control the immune response. It is believed that the folding topology of the β‐sheets of the interleukin‐4 receptor (IL4R) is the same as that seen in the crystal structure of CD4. Although the sequence identity is low,
P, Bamborough, G H, Grant, C J, Hedgecock, S P, West, W G, Richards   +4 more
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Molecular Analysis of Adrenergic Receptor Genes And Interleukin-4/interleukin-4 Receptor Genes in Patients With Interstitial Cystitis

Journal of Urology, 2002
Interstitial cystitis is a chronic and sterile inflammatory disease of the bladder. Clinically many patients with interstitial cystitis also have allergic or autoimmune diseases. Recent studies have suggested that allelic variations in the adrenergic receptor beta2 gene, the interleukin (IL)-4 gene and its receptor gene are closely associated with ...
Kimio, Sugaya, Saori, Nishijima, Tetsuo, Yamada, Minoru, Miyazato, Tadashi, Hatano, Yoshihide, Ogawa   +5 more
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Interleukin-4 Receptors

1995
Abstract Both the murine (Mosley et al. 1989) and human (ldzerda et al. 1990) IL-4 receptors have been molecularly cloned. The murine IL-4 receptor, which was cloned first (Mosley et al. 1989), is produced as an 810-amino-acid precursor with a predicted 25-amino-acid signal peptide (GenBank accession number M27959).
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Linked in vivo expression of soluble interleukin‐4 receptor and interleukin‐4 in murine schistosomiasis

European Journal of Immunology, 1995
AbstractSoluble interleukin‐4 receptors (sIL‐4R) are truncated IL‐4R molecules that are secreted into biological fluids. To gain an insight into the mechanisms that control sIL‐4R synthesis in vivo and their role in the regulation of immune responses, the expression and secretion of sIL‐4R in mice infected with Schistosoma mansoni was studied ...
R, Fernandez-Botran, T A, Wynn, S, Hieny, P, Caspar, P M, Chilton, A, Sher   +5 more
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Interleukin 4, interleukin 4 receptor‐α and interleukin 10 gene polymorphisms in Chagas disease

Parasite Immunology, 2011
SummaryIn this study, we investigated the association between single‐nucleotide polymorphisms (SNPs) of the interleukin‐4 (IL4), interleukin‐4 receptor‐α (IL4RA) and interleukin‐10 (IL10) genes with the development of chagasic heart disease. This study included 260 patients from Colombia who were serologically positive for Trypanosoma cruzi antigens ...
O, Flórez, J, Martín, C I, González
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