Results 51 to 60 of about 991,315 (356)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages [PDF]

, 2009
Background Toll-like receptors (TLRs) are present on monocytes and alveolar macrophages that form the first line of defense against inhaled particles.
Esmaeil Mortaz, Nijkamp, Frans P, Caldenhoven Eric, Caldenhoven, Eric, Kraneveld, Aletta D, Gert Folkerts, Sarir Hadi, Folkerts Gert, Nijkamp Frans P, Khalil Karimi, Kraneveld Aletta D, Karimi Khalil, Sarir, Hadi, Mortaz Esmaeil, Karimi, Khalil, Rahman Irfan, Folkerts, Gert, Frans P Nijkamp, Rahman, Irfan, Irfan Rahman, Eric Caldenhoven, Aletta D Kraneveld, Mortaz, Esmaeil, Hadi Sarir   +23 more
core   +1 more source

Imidazoline receptors in the heart: a novel target and a novel mechanism of action that involves atrial natriuretic peptides

Brazilian Journal of Medical and Biological Research, 2004
Chronic stimulation of sympathetic nervous activity contributes to the development and maintenance of hypertension, leading to left ventricular hypertrophy (LVH), arrhythmias and cardiac death.
S. Mukaddam-Daher, J. Gutkowska
doaj   +1 more source

Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor [PDF]

Open Biology, 2012
Certain disulfide bonds present in leucocyte membrane proteins are labile and can be reduced in inflammation. This can cause structural changes that result in downstream functional effects, for example, in integrin activation.
Clive Metcalfe, Peter Cresswell, A. Neil Barclay   +2 more
doaj   +1 more source

Association of Severe Respiratory Syncytial Virus Bronchiolitis with Interleukin‐4 and Interleukin‐4 Receptor α Polymorphisms [PDF]

The Journal of Infectious Diseases, 2003
The association of variants of genes encoding interleukin (IL)-4 and the IL-4 receptor alpha chain (IL-4Ralpha) with respiratory syncytial virus (RSV) bronchiolitis was examined in hospitalized infants. Polymorphisms in IL-4 (C-590T) and IL-4Ralpha (I50V and Q551R) were genotyped by restriction fragment-length polymorphism analysis.
Hoebee, B, Rietveld, E (Edwin), de Bont, L (Louis), van Oosten, M, Hodemaekers, HM, Auvinen, Anssi-Pekka, Neijens, HJ (Herman), Kimpen, JLL, Kimman, TG   +8 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 101-111).Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N ...
Brombacher, Tiroyaone M H
core  

Modulation of human immune responses by bovine interleukin-10 [PDF]

, 2011
Cytokines can be functionally active across species barriers. Bovine IL-10 has an amino acid sequence identity with human IL-10 of 76.8%. Therefore, the aim of this study was to evaluate whether bovine IL-10 has immunomodulatory activities on human ...
Schoemaker, R., de Ruiter, T., Weg-Schrijver, Elise, van de, Westphal Adrie H., Tijhaar, E., Savelkoul, H.F.J., Adrie H Westphal, Westphal, A.H., Savelkoul Huub F. J., R J Joost van Neerven, Edwin Tijhaar, Neerven, R.J.J., van, Gerco den Hartog, van de Weg-Schrijver Elise, Schoemaker Ruud, den Hartog Gerco, den Hartog, C.G., Huub F J Savelkoul, van de Weg-Schrijver, Elise, Talitha de Ruiter, Elise van de Weg-Schrijver, de Ruiter Talitha, Ruiter, T., de, Ruud Schoemaker, van Neerven, R.J.J., Hartog, C.G., den, Tijhaar Edwin, van Neerven R. J. Joost   +27 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Mechanisms by which interleukin-4 suppresses inflammatory cytokine production by activated human monocytes [PDF]

, 2011
Improving understanding of how inflammatory responses by monocytes and macrophages are regulated may aid in the development of more targeted therapies for chronic inflammatory disease.
Woodward, Eleanor
core   +1 more source