Results 41 to 50 of about 991,315 (356)

The Effect of Hypertonic Saline on mRNA of Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Polymorphonuclear Cells

Current Therapeutic Research, 2014
Background: Hypertonic saline is often used to resuscitate patients experiencing shock. In such conditions, polymorphonuclear cells and Toll-like receptors (TLRs) form an essential part of early induced innate immunity.
Sung-Hyuk Choi, MD, PhD, Young-Hoon Yoon, MD, PhD, Jung-Youn Kim, MD, PhD, Sung-Woo Moon, MD, PhD, Young-Duck Cho, MD, PhD, Ji-Won Yeom   +5 more
doaj   +1 more source

Characterisation of bovine leukocyte Ig-like receptors [PDF]

, 2012
Leukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have ...
Laing Ken, Martin Vordermeier, John Trowsdale, Singh Mahavir, Philip Butcher (173962), Allen Rachel L., Ken Laing, Laing, K, Butcher, P, Mahavir Singh, Des C Jones, Butcher, Philip, Bhuju, S, Ken Laing (173955), Vordermeier, M, Singh, Mahavir, Jones, DC, Trowsdale, John, Mahavir Singh (70735), Rachel L Allen, Hogan, Louise, Trowsdale, J, Hogan Louise, Vordermeier Martin, Hogan, L, Philip Butcher, Singh, M, Allen, RL, Des C. Jones (173949), Louise Hogan (173942), John Trowsdale (1225), Martin Vordermeier (108962), Trowsdale John, Vordermeier, Martin, Allen, Rachel L, Jones Des C., Sabin Bhuju, Laing, Ken, Bhuju Sabin, Sabin Bhuju (107606), Rachel L. Allen (173972), Jones, Des C, Bhuju, Sabin, Louise Hogan, Butcher Philip   +44 more
core   +1 more source

Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells.

Journal of Immunology, 1988
In this report a method for the affinity purification and radiolabeling of recombinant mouse interleukin (IL)-4 is described. It is shown on the basis of several criteria that IL-4 retains full biologic activity after radioiodination and can therefore be
J. Lowenthal, B. Castle, J. Christiansen, J. Schreurs, D. Rennick, N. Arai, P. Hoy, Y. Takebe, M. Howard   +8 more
semanticscholar   +1 more source

Priming by recombinant chicken interleukin-2 induces selective expression of IL-8 and IL-18 mRNA in chicken heterophils during receptor-mediated phagocytosis of opsonized and nonopsonized Salmonella enterica serovar enteritidis [PDF]

, 2003
Heterophils, the principal avian polymorphonuclear leukocytes (PMNs) equivalent to the mammalian neutrophil, function as professional phagocytes against bacterial infections, mediate acute inflammation, and respond to cytokine stimulation to aid in ...
Michael H Kogut, Pete Kaiser, Kogut, Michael H, Kaiser, Pete, Lisa Rothwell, Rothwell, Lisa   +5 more
core   +1 more source

Recent Progress in the Molecular Recognition and Therapeutic Importance of Interleukin-1 Receptor-Associated Kinase 4

Molecules, 2016
Toll-like receptors (TLRs) are the most upstream pattern recognition receptors in the cell, which detect pathogen associated molecular patterns and initiate signal transduction, culminating in the transcription of pro-inflammatory cytokines and antiviral
Mahesh Chandra Patra, Sangdun Choi
doaj   +1 more source

Novel IL2RG Gene Mutation in One of Dizygotic Twins Causing Profound Changes of Receptor Structure

Frontiers in Pediatrics, 2022
In this study, we report a 4-month-old boy with T−B+NK− severe combined immunodeficiency (SCID) due to a novel mutation in exon 2 of IL2RG, the gene encoding the interleukin (IL) common gamma chain (γc) of the cytokine receptors for IL-2, IL-4, IL-7, IL ...
Magdalena Rutkowska-Zapała, Anna Szaflarska, Anna Kluczewska, Julia Ciȩciwa, Jacek Plewka, Anna Michalska, Maciej Siedlar   +6 more
doaj   +1 more source

An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13- induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors

Journal of Experimental Medicine, 1993
Interleukin 4 (IL-4) and IL-13 share many biological functions. Both cytokines promote growth of activated human B cells and induce naive human surface immunoglobulin D+ (sIgD+) B cells to produce IgG4 and IgE. Here we show that a mutant form of human IL-
G. Aversa, J. Punnonen, Benjamin G. Cocks, René De, Waal Malefyt, Felix Vega, S. Zurawski, G. Zurawski, Jan E. de Vries   +8 more
semanticscholar   +1 more source

Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells [PDF]

, 2013
Background Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related hypertension with SNS activation accelerates progression of non-alcoholic fatty liver ...
Vander Borght, S, McKee, C, Vander Borght Sara, Mazzoccoli, G, Ching-I Lin, Gianluigi Mazzoccoli, Lin Ching-I, Selden, C, Maelle Morgan, Pazienza Valerio, Selden Clare, Junpei Soeda, Lin, C, Jude A Oben, Barbara Sigala, Manlio Vinciguerra, Oben, JA, Tania Roskams, Sara Vander Borght, Pazienza, V, Roskams, T, Clare Selden, Lin, CI, McKee Chad, Mazzoccoli Gianluigi, Vinciguerra, M, Morgan Maelle, Valerio Pazienza, Sigala Barbara, Vinciguerra Manlio, Soeda, J, Chad McKee, Soeda Junpei, Oben Jude A., Sigala, B, Roskams Tania, Morgan, M   +36 more
core   +1 more source

Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases

Reviews in Cardiovascular Medicine, 2022
Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) directly interact with intracellular interleukin receptor associated kinase (IRAK) family members to initialize innate immune and inflammatory responses following activation by pathogen ...
Youjing Zheng, Jia-Qiang He
doaj   +1 more source

Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes

Journal of Experimental Medicine, 1987
Human rIL-4 is able to induce the expression of low-affinity receptors for IgE (Fc epsilon RL/CD23) on resting B lymphocytes, as determined by the binding of either the anti Fc epsilon RL/CD23-specific mAb 25 or IgE.
T. Defrance, J. Aubry, F. Rousset, B. Vanbervliet, J. Bonnefoy, N. Arai, Y. Takebe, T. Yokota, F. Lee, K. Arai   +9 more
semanticscholar   +1 more source