Results 271 to 280 of about 499,428 (289)

Functional analysis of the interleukin-5 receptor antagonist peptide, AF18748

Cytokine, 2004
AF18748 is a dimeric peptide of 2 x 19 amino acids that specifically binds to the alpha-chain of the human IL-5 receptor (IL-5R), preventing binding of IL-5 and acting as a receptor antagonist. However, the peptide acts by inducing alpha-chain dimerization, and we therefore set out to investigate whether this peptide would have any residual agonist ...
Marcela, Rosas, Iain J, Uings, Cornelli, van Aalst, Jan-Willem J, Lammers, Leo, Koenderman, Paul J, Coffer   +5 more
openaire   +3 more sources

Soluble Interleukin-5 Receptor α-Chain Binding Assays: Use for Screening and Analysis of Interleukin-5 Mutants

Analytical Biochemistry, 1995
Interleukin-5 (IL-5) is a key cytokine for the production, differentiation, and activation of eosinophils. IL-5 is a member of the four helical bundle family of cytokines, and in common with many members of the cytokine family it binds to a heterodimeric receptor composed of a ligand binding alpha-chain and a signal-transducing beta-chain.
M, Banks, P, Graber, A E, Proudfoot, C Y, Arod, B, Allet, A R, Bernard, E, Sebille, M, McKinnon, T N, Wells, R, Solari   +9 more
openaire   +2 more sources

Interleukin-5 Receptor and CD5-Positive B Cells

Methods, 1995
Abstract Interleukin-5 (IL-5) is a cytokine that stimulates proliferation and differentiation of B cells including CD5-positive B (B-1) cells and eosinophils. IL-5 signals can be transduced through IL-5 receptor (IL-5R) that is composed of α and βc chains.
Kiyoshi Takatsu, Ai Kariyone, Taku Kouro, Yuji Kikuchi, Yasumichi Hitoshi, Satoshi Takaki   +5 more
openaire   +1 more source

Enhanced soluble interleukin‐5 receptor alpha expression in nasal polyposis

Allergy, 2003
Background: Alternative splicing of the interleukin‐5 receptor alpha (IL‐5Rα)‐subunit leads to the generation of a signalling, membrane‐anchored (TM) isoform, or a secreted [soluble (SOL)], antagonistic variant. Given the key role of IL‐5 in eosinophil function, we investigated SOL IL‐5Rα expression pattern in an eosinophil‐associated disease such as ...
P, Gevaert, C, Bachert, G, Holtappels, C P, Novo, J, Van der Heyden, L, Fransen, S, Depraetere, H, Walter, P, van Cauwenberge, J, Tavernier   +9 more
openaire   +2 more sources

Biological and Molecular Characteristics of Interleukin-5 and its Receptor

International Reviews of Immunology, 1998
Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders.
S, Karlen, M L, De Boer, R J, Lipscombe, W, Lutz, V A, Mordvinov, C J, Sanderson   +5 more
openaire   +2 more sources

The Interleukin-5 Receptor

1995
Abstract The nucleotide sequence of the human IL-5Ra cDNA (GenBank accession numbers M75914, M96651, M96652, X61176, X61177, X61178, and X62156) predicts a polypeptide of 420 amino acids (Fig. 1) (Tavernier et al. 1991, 1992; Murata et al. 1992).
openaire   +1 more source

Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor

International Immunopharmacology, 2002
Interleukin-5 (IL-5) plays an important role in the activation of eosinophils in allergic inflammation including asthma and atopic dermatitis. A newly synthesized compound, YM-90709, 2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino [2,3-b]quinoxaline, is reported here to inhibit the binding of IL-5 to its receptor on peripheral human ...
Tatsuaki, Morokata, Kenji, Ida, Toshimitsu, Yamada   +2 more
openaire   +2 more sources

Expression of the murine interleukin-5 receptor on Xenopus laevis oocytes

Biochemical and Biophysical Research Communications, 1990
In this study we describe the use of Xenopus laevis oocytes for the detection of mRNA coding for a murine interleukin-5 (mI15) receptor. When injected with sucrose gradient fractionated polyA+ RNA derived from the murine 115-dependent pre B cell line B13, these oocytes could specifically bind 35S-methionine labeled mI15.
R, Devos, J, Tavernier, G, Plaetinck, J, Van der Heyden, A, Rolink, W, Fiers   +5 more
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Interleukin‐5 receptors on human lung eosinophils after segmental allergen challenge

Clinical & Experimental Allergy, 2004
SummaryBackground IL‐5 is a specific cytokine for eosinophil accumulation, activation and prolongation of survival and can be recovered in elevated concentrations from the bronchoalveolar compartment in atopic asthma following allergen challenge.Objective The action of IL‐5 is mediated via the specific IL‐5 receptor‐α (IL‐5Rα).
Julius, Peter, Hochheim, D., Boser, K., Schmidt, Stephanie, Myrtek, Daniel, Bachert, Claus, Luttmann, Werner, Virchow, Johann Christian   +7 more
openaire   +3 more sources

Identification of the second subunit of the murine interleukin-5 receptor: interleukin-3 receptor-like protein, AIC2B is a component of the high affinity interleukin-5 receptor.

The EMBO Journal, 1991
Murine interleukin-5 (IL-5) binds to its receptor with high and low affinity. It has been shown that the high affinity IL-5 receptor (IL-5-R) is composed of at least two membrane protein subunits and is responsible for IL-5-mediated signal transduction.
S, Takaki, S, Mita, T, Kitamura, S, Yonehara, N, Yamaguchi, A, Tominaga, A, Miyajima, K, Takatsu   +7 more
openaire   +2 more sources