Results 81 to 90 of about 10,025,178 (148)

Mecanismos envolvidos na hipernocicepção mecânica muscular induzida pela Interleucina-6 (IL-6) em camundongos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010O objetivo do presente estudo foi investigar os possíveis mecanismos e mediadores envolvidos na ...
Manjavachi, Marianne Neves
core  

Pathogens and Dead Cells Cooperate with Cytokines in Activating the Innate and Adaptive Response

European Journal of Inflammation, 2011
After microbial invasion and tissue damage, a set of cytokines, including interleukin-1α (IL-1α), IL-1β, IL-6, IL-18 and tumor necrosis factor-α (TNF-α), and microbial and endogenous molecules named pathogen-associated molecular pattern (PAMPs) and ...
J.E. Belizário
doaj   +1 more source

Natural AI-based drug designing by modification of ascorbic acid and curcumin to combat buprofezin toxicity by using molecular dynamics study

Scientific Reports
Buprofezin, a widely employed insecticide in agricultural practices, has elicited significant apprehension due to its prospective deleterious effects on non-target organisms and ecological systems.
Haleema Sadia, Irfan Zia Qureshi, Muhammad Naveed, Tariq Aziz, Metab Alharbi, Abdullah F. Alasmari, Thamer H. Albekairi   +6 more
doaj   +1 more source

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

, 2007
Interleukin-6 (IL-6) is a key inflammatory cytokine, signalling to most tissues by binding to a soluble IL-6 receptor (sIL-6r), making a complex with gp130.
A Murray, Henley, W, Bandinelli, S, S Rafiq, Rafiq, S, Weedon, MN, Guralnik, JM, Hurst, A, A-M Corsi, Ferrucci, L, K Stevens, S Bandinelli, M N Weedon, Corsi, A-M, L Ferrucci, Murray, A, D Melzer, W Henley, T M Frayling, J M Guralnik, A Hurst, Stevens, K, Melzer, D, Frayling, TM   +23 more
core   +1 more source

Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration

Frontiers in Cellular Neuroscience
Microglia, the innate immune cells of the central nervous system (CNS), play essential roles in maintaining neural homeostasis through dynamic interactions with neurons and other brain structures.
Guang Yang, Guang Yang, Xiao Xu, Waimao Gao, Xingyu Wang, Yan Zhao, Ying Xu   +6 more
doaj   +1 more source

Pharmacotherapy for rheumatoid arthritis in the early 21st century: Russian and international experience

Терапевтический архив, 2013
The paper summarizes the data of international and Russian studies concerning current approaches to the pharmacotherapy of rheumatoid arthritis. Particular emphasis is placed on the substantiation of the treat-to-target concept, on the efficacy and ...
E L Nasonov, D E Karateev, G V Lukina
doaj  

The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 101-111).Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N ...
Brombacher, Tiroyaone M H
core   +1 more source

Mechanisms by which interleukin-4 suppresses inflammatory cytokine production by activated human monocytes [PDF]

, 2011
Improving understanding of how inflammatory responses by monocytes and macrophages are regulated may aid in the development of more targeted therapies for chronic inflammatory disease.
Woodward, Eleanor
core  

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Therapeutic Targeting of the Interleukin-6 Receptor

Annual Review of Pharmacology and Toxicology, 2012
Interleukin (IL)-6 is a typical cytokine featuring redundancy and pleiotropic activity. It contributes to host defense against pathogens, but dysregulation of IL-6 production plays a significant pathological role in various autoimmune and inflammatory diseases.
Masashi Narazaki, Tadamitsu Kishimoto
exaly   +3 more sources

Interleukin-6 and interleukin-6 receptor gene expression in pituitary tumors

Journal of Neuro-Oncology, 1994
Interleukin-6 (IL-6) is a multifunctional cytokine which plays a role in the stimulation, inhibition, differentiation, and regulation of cell growth. IL-6 has been shown to act as an autocrine growth factor in several tumors, and is expressed by a variety of tumors. IL-6 also exhibits a regulatory role in the hypothalamo-pituitary axis.
A R, Rezai, A, Rezai, O, Martínez-Maza, M, Vander-Meyden, M H, Weiss   +4 more
openaire   +2 more sources