Results 261 to 270 of about 516,089 (311)
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Biochemical and Biophysical Research Communications, 1993
Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4 ...
K, Izuhara, A, Miyajima, N, Harada
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Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4 ...
K, Izuhara, A, Miyajima, N, Harada
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Blocking interleukin-1 receptors
International Journal of Clinical & Laboratory Research, 1994During inflammation, injury, immunological challenge or infection, interleukin-1 appears to mediate, in part, the pathogenesis, of disease. Most studies on interleukin-1 are derived from experiments in which bacterial products, such as endotoxins from Gram-negative bacteria or exotoxins from Gram-positive organisms, are used to stimulate macrophagic ...
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Interleukin-1 Receptor Antagonist
1993IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by three criteria: amino acid sequence homology of 26 to 30% to IL-1 beta and 19% to IL-1 alpha; similarities in gene structure; and common gene localization to human chromosome 2q14.
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1995
Abstract The human IL-7 receptor is produced as a 459-amino-acid precursor with a predicted 20-amino-acid signal peptide (GenBank accession number M29696) (Fig. 1). It contains a single transmembrane domain of 25 amino acids, an extracellular domain of 219 amino acids, and a cytoplasmic domain of 195 amino acids.
R G Goodwin, L S Park
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Abstract The human IL-7 receptor is produced as a 459-amino-acid precursor with a predicted 20-amino-acid signal peptide (GenBank accession number M29696) (Fig. 1). It contains a single transmembrane domain of 25 amino acids, an extracellular domain of 219 amino acids, and a cytoplasmic domain of 195 amino acids.
R G Goodwin, L S Park
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1985
Interleukin-2 (IL-2) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors but receptors are rapidly expressed on T-cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen specific T-cell receptor complex.
Thomas A. Waldmann +6 more
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Interleukin-2 (IL-2) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors but receptors are rapidly expressed on T-cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen specific T-cell receptor complex.
Thomas A. Waldmann +6 more
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Enhancing Interleukin-6 and Interleukin-11 receptor cleavage
The International Journal of Biochemistry & Cell Biology, 2017Proteolytic cleavage of the membrane-bound Interleukin-6 receptor (IL-6R) by the metalloprotease ADAM17 releases an agonistic soluble form of the IL-6R (sIL-6R), which is responsible for the pro-inflammatory trans-signaling branch of the cytokine's activities.
Juliane, Lokau +2 more
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Clinical & Experimental Ophthalmology, 2009
AbstractPurpose: Interleukin‐1 (IL‐1) is known to have an important role in pathogenesis of Graves' ophthalmopathy (GO). Polymorphisms in IL‐1 gene have been associated with autoimmune reactions. This study aimed to investigate the association of GO with single‐nucleotide polymorphisms (SNPs) in the IL‐1 family (IL‐1α, IL‐1β, IL‐1 receptor [IL‐1R] and
Omid, Khalilzadeh +7 more
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AbstractPurpose: Interleukin‐1 (IL‐1) is known to have an important role in pathogenesis of Graves' ophthalmopathy (GO). Polymorphisms in IL‐1 gene have been associated with autoimmune reactions. This study aimed to investigate the association of GO with single‐nucleotide polymorphisms (SNPs) in the IL‐1 family (IL‐1α, IL‐1β, IL‐1 receptor [IL‐1R] and
Omid, Khalilzadeh +7 more
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The interleukin 1 receptor family
Developmental & Comparative Immunology, 2004Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor and a receptor accessory protein. These two molecules are members of a wider family of proteins that have in common the presence of immunoglobulin domains in the extracellular region of the protein and a TIR domain in the cytoplasmic region.
Sumathi, Subramaniam +2 more
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The interleukin-1/interleukin-1-receptor interaction
Annales de l'Institut Pasteur / Immunologie, 1987H R, MacDonald, J W, Lowenthal
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