Results 41 to 50 of about 1,112,126 (259)

Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages [PDF]

, 2009
Background Toll-like receptors (TLRs) are present on monocytes and alveolar macrophages that form the first line of defense against inhaled particles.
Esmaeil Mortaz, Nijkamp, Frans P, Caldenhoven Eric, Caldenhoven, Eric, Kraneveld, Aletta D, Gert Folkerts, Sarir Hadi, Folkerts Gert, Nijkamp Frans P, Khalil Karimi, Kraneveld Aletta D, Karimi Khalil, Sarir, Hadi, Mortaz Esmaeil, Karimi, Khalil, Rahman Irfan, Folkerts, Gert, Frans P Nijkamp, Rahman, Irfan, Irfan Rahman, Eric Caldenhoven, Aletta D Kraneveld, Mortaz, Esmaeil, Hadi Sarir   +23 more
core   +1 more source

Soluble Interleukin 2 Receptors' Levels Versus Thyroid Hormones Levels in Nonthyroidal Disease

Acta Medica, 1999
Serum soluble interleukin-2 receptor levels, basal thyrotropin, total thyroxine, total triiodothyronine and free triodothyronine were assayed in 29 - otherwise healthy - patients with pulmonary tuberculosis before initiation of anti-tuberculosis ...
Ioannis Ilias, Georgios Panoutsopoulos, Nikiforos Filippou, Anna Dima, Ioulia Christakopoulou, Paraskevi Roussou   +5 more
doaj   +1 more source

Exploring the role of interleukin-27 as a regulator of neuronal survival in central nervous system diseases

Neural Regeneration Research, 2022
Interleukin-27 is a pleiotropic cytokine that is involved in tissue responses to infection, cell stress, neuronal disease, and tumors. Recent studies in various tissues indicate that interleukin-27 has complex activating and inhibitory properties in ...
Andrea N Nortey, Kimberly N Garces, Abigail S Hackam   +2 more
doaj   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 101-111).Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N ...
Brombacher, Tiroyaone M H
core   +1 more source

Cortisol Dose-Dependently Impairs Migration and Tube-like Formation in a Trophoblast Cell Line and Modulates Inflammatory and Angiogenic Genes

Biomedicines, 2021
Several stimuli can change maternal hormone levels during pregnancy. These changes may affect trophoblastic cells and modulate the development of the embryo and the placental tissue itself.
Talita Guerreiro Rodrigues Húngaro, Marcos F. Gregnani, Thaís Alves-Silva, Florian Herse, Natalia Alenina, Michael Bader, Ronaldo C. Araújo   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Signal transduction of Interleukin-11 and Interleukin-6 ?-Receptors [PDF]

, 2016
The cytokines Interleukin (IL)-11 and IL-6 are important mediators that regulate differentiation and proliferation of immune cells. Both cytokines bind to unique non-signaling ?-receptors (IL-11R and IL-6R, respectively), and the resulting cytokine ...
Juliane Lokau, Christoph Garbers
core