Results 91 to 100 of about 15,962 (236)
Corticotropin-releasing hormone is a rapid and potent convulsant in the infant rat [PDF]
, 1991 Corticotropin-releasing hormone (CRH) administered into the cerebral ventricles of rats during the first postnatal week caused a specific and stereotyped behavior sequence: rhythmic chewing and licking (jaw myoclonus) were followed by 'limbic'-type ...
BARAM, TZ
core +4 more sources
Pharmacological preconditioning with GYKI 52466: a prophylactic approach to neuroprotection
Frontiers in Neuroscience, 2010 Some toxins and drugs can trigger lasting neuroprotective mechanisms that enable neurons to resist a subsequent severe insult. This ‘pharmacological preconditioning’ has far-reaching implications for conditions in which blood flow to the ...
Chelsea S Goulton +3 more
doaj +1 more source
Spindle oscillations are generated in the dorsal thalamus and modulated by the thalamic reticular nucleus [PDF]
, 2008 Spindle waves occur during the early stage of slow wave sleep and are thought to arise in the thalamic reticular nucleus (TRN), causing inhibitory postsynaptic potential spindle-like oscillations in the dorsal thalamus that are propagated to the cortex ...
Chun-Hua Liu +7 more
core +1 more source
A latent serotonin-1A receptor-gated spinal afferent pathway inhibiting breathing [PDF]
, 2015 Spinal afferents such as nociceptive afferents and group III–IV muscle afferents are known to exert an acute excitatory effect on breathing when activated. Here, we report the surprising existence of latent spinal afferents which exerted tonic inhibitory
Ning, Yinghui +3 more
core +1 more source
Epilepsia, Volume 67, Issue 4, Page 1614-1626, April 2026.Abstract Objective One‐third of patients with epilepsy, particularly those with mesial temporal lobe epilepsy (MTLE), remain resistant to medication. Resective surgery, the gold standard, is highly invasive and carries significant risks. Here, using a mouse model, we explored the potential of microbeam radiation therapy (MRT), a new technique based on ...
Loan Samalens +8 more
wiley +1 more source
Neurobiology of Disease, 2016 Neonatal seizures are associated with long term disabilities including epilepsy and cognitive deficits. Using a neonatal seizure rat model that does not develop epilepsy, but develops a phenotype consistent with other models of intellectual disability ...
Heather O'Leary +3 more
doaj +1 more source
Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo. [PDF]
, 2013 14-3-3 proteins are ubiquitous molecular chaperones that are abundantly expressed in the brain where they regulate cell functions including metabolism, the cell cycle and apoptosis.
Brennan, Gary P +5 more
core +3 more sources
Epilepsia, Volume 67, Issue 4, Page 1665-1678, April 2026.Abstract Objective Epilepsy is a chronic neurological disorder characterized by recurrent seizures and frequent cognitive and psychiatric comorbidities. Although current antiseizure medications provide symptomatic relief, they fail to prevent or modify epileptogenesis.
Yara Sheeni +8 more
wiley +1 more source
Neurobiology of Disease, 2017 Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders accompanied by intractable epilepsies, i.e. West syndrome or atypical Rett syndrome.
Kosuke Okuda +17 more
doaj +1 more source
Developmental seizures induced by common early-life insults: short- and long-term effects on seizure susceptibility. [PDF]
, 2000 The immature brain is highly susceptible to seizures induced by a variety of insults, including hypoxia, fever, and trauma. Unlike early life epilepsy associated with congenital dysplasias or genetic abnormalities, insults induce a hyperexcitable state ...
Baram, TZ, Jensen, FE
core +2 more sources