Results 101 to 110 of about 15,962 (236)

Interferon-α2b Modulates AMPA and Kainate Receptors and Alters Cross Talk of AMPA and NMDA Receptors in the Frog Vestibular Epithelium

Frontiers in Bioscience-Landmark
Background: Interferons (IFNs) are ototoxic drugs leading to vestibular and auditory disorders. This study investigated the effect of pro-inflammatory cytokine IFN-α2b on the afferent glutamatergic synaptic transmission of the ...
Irina V. Ryzhova, Elena A. Vershinina, Alexander G. Markov, Tatyana V. Tobias   +3 more
doaj   +1 more source

Submicromolar copper (II) ions stimulate transretinal signaling in the isolated retina from wild type but not from Cav2.3-deficient mice

BMC Ophthalmology, 2020
Background So far, only indirect evidence exists for the pharmacoresistant R-type voltage-gated Ca2+ channel (VGCC) to be involved in transretinal signaling by triggering GABA-release onto ON-bipolar neurons.
Jan Niklas Lüke, Felix Neumaier, Serdar Alpdogan, Jürgen Hescheler, Toni Schneider, Walid Albanna, Isha Akhtar-Schäfer   +6 more
doaj   +1 more source

Epileptogenesis in the developing brain: what can we learn from animal models? [PDF]

, 2007
Knowledge of the processes by which epilepsy is generated (epileptogenesis) is incomplete and has been a topic of major research efforts. Animal models can inform us about these processes. We focus on the distinguishing features of epileptogenesis in the
Baram, Tallie Z, Bender, Roland A
core   +1 more source

Loss of cyclin‐dependent kinase‐like 5 results in susceptibility to audiogenic seizures in mice

Epilepsia Open, Volume 11, Issue 2, Page 670-678, April 2026.
Abstract CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental encephalopathy characterized by early‐onset, treatment‐resistant epilepsy. Mice lacking CDKL5 display several clinically relevant phenotypes, but spontaneous seizures are not consistently reported, and it is unknown if CDD model mice are susceptible to sensory stimulus‐triggered ...
Jordan Higgins, Samuel Egan, Bilal El‐Mansoury, David C. Henshall, Omar Mamad   +4 more
wiley   +1 more source

Corticotropin‐releasing hormone–induced seizures in infant rats originate in the amygdala [PDF]

, 1992
The neuroanatomical substrate of seizures induced by picomolar amounts of corticotropin‐releasing hormone in infant rats was investigated. Electrographic and behavioral phenomena were monitored in 42 rat pups aged 5 to 22 days.
Albala, Baram, Baram, Baram, Baram, Baram, Ben-Ari, Bohmer, Cavalheiro, Cherubini, De Souza, Ehlers, Ehlers, Gilbert, Gray, Grino, Holmes, Ikonomidou-Turski, Insel, Koob, Lothman, Marrosu, Marrosu, Moshe, Oliverio, Ortolani, Palkovits, Pokorny, Sherwood, Siggins, Vale, Vale, Valentino, Watts   +33 more
core   +2 more sources

Honey as a Natural Flavorful Product: A Comprehensive Review of Its Potential Biological Activities and Recent Studies

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Health impacts of honey. ABSTRACT Honey is a natural and nutritious product of the honey bee (Apis mellifera) with low water content. Its color ranges from white to amber, with taste varying accordingly. The chemical form and viscosity of honey depend on its composition.
Ecem Bolat, Ahmet Alperen Canbolat, Sümeyye Sarıtaş, Mauro Lombardo, Anna Maria Witkowska, Hesham El‐Seedi, Mikhael Bechelany, Sercan Karav   +7 more
wiley   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, Volume 293, Issue 7, Page 2067-2085, April 2026.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. [PDF]

, 1999
Febrile (fever-induced) seizures affect 3-5% of infants and young children. Despite the high incidence of febrile seizures, their contribution to the development of epilepsy later in life has remained controversial.
Baram, TZ, Chen, K, Soltesz, I
core   +1 more source

Serotonin receptor antagonists increase fast ripple activity in rats treated with kainic acid

Brain Research Bulletin, 2016
Fast ripples (FR, 250-600 Hz) are field potentials that occur only in those areas capable of generating seizures, such as the hippocampus, and modulation of FR by serotonin has been reported. Therefore, we hypothesized that the receptor antagonists 5HT1A and 5HT2A, B, C will increase FR in rats treated with kainic acid (KA, 0.8 μg/0.5 μl).
Carla, García-Barba, Laura, Medina-Ceja
openaire   +2 more sources

Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus [PDF]

, 2012
Abnormalities of synaptic transmission and plasticity in the hippocampus represent an integral part of the altered programming triggered by early life stress.
Bouwalerh, H., Maccari, S., Mairesse, J., Marrocco, J., Morley-Fletcher, S., Ngomba, R.T., Nicoletti, F., Pittaluga, A., Silletti, V., Summa, M., Van Camp, G.   +10 more
core   +1 more source