Results 111 to 120 of about 15,962 (236)

Structure and function of NMDA-type glutamate receptor subunits

Neurología (English Edition), 2012
Introduction: To review the physiology of the glutamate receptor subunits such as N-methyl-d-aspartate (NMDA). Development: Glutamic acid (Glu) is the major excitatory neurotransmitter in the central nervous system (CNS) which interacts with two types ...
M.E. Flores-Soto, V. Chaparro-Huerta, M. Escoto-Delgadillo, E. Vazquez-Valls, R.E. González-Castañeda, C. Beas-Zarate   +5 more
doaj   +1 more source

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation [PDF]

, 2016
Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Brain inflammation is increasingly recognized as a critical factor for seizure precipitation, but the molecular mediators of such proconvulsant effects are only partly ...
Allegra, M, Bozzi, Y, Caleo, M, Cerri, C, Genovesi, S, Guglielmotti, A, Ntener, Up, Perry, Vh, Pistillo, F   +8 more
core   +2 more sources

Regional Susceptibility to Domoic Acid in Primary Astrocyte Cells Cultured from the Brain Stem and Hippocampus

Marine Drugs, 2008
Domoic acid is a marine biotoxin associated with harmful algal blooms and is the causative agent of amnesic shellfish poisoning in marine animals and humans.
Olga M. Pulido, Talat Ghane, Yangxun Hou, Santokh S. Gill   +3 more
doaj  

Estructura y función de las subunidades del receptor a glutamato tipo NMDA

Neurología, 2012
Resumen: Introducción: Realizar una revisión de la fisiología de las subunidades del receptor a glutamato tipo N-metil-D-aspartato (NMDA). Desarrollo: El acido glutámico (Glu) es el principal neurotransmisor excitador del sistema nervioso central la ...
M.E. Flores-Soto, V. Chaparro-Huerta, M. Escoto-Delgadillo, E. Vazquez-Valls, R.E. González-Castañeda, C. Beas-Zarate   +5 more
doaj   +1 more source

Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases [PDF]

, 2014
Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development.
Andrade, Paula B., Ferreres, Federico, Grosso, Clara, Valentão, Patricia   +3 more
core   +2 more sources

LPM682000012, a Synthetic Neuroactive Steroid That Ameliorates Epileptic Seizures by Downregulating the Serpina3n/NF-κB Signaling Pathway

Molecules
Epilepsy is characterized by abnormal neuronal firing in the brain. Several therapeutic strategies exist for epilepsy; however, several patients remain poorly treated.
Xiaofan Zhang, Shengmin Ji, Yue Yang, Xiaohui Sun, Hui Wang, Yifan Yang, Xuan Deng, Yunjie Wang, Chunmei Li, Jingwei Tian   +9 more
doaj   +1 more source

Spatial transcriptomics in epilepsy research: Early successes, opportunities, and challenges

Epilepsia, Volume 67, Issue 4, Page 1589-1600, April 2026.
Donald J. Phillips, Autumn S. Ivy, Samuel Guzman, Saman Hazany, Xiangmin Xu   +4 more
wiley   +1 more source

KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q

Frontiers in Molecular Neuroscience
IntroductionThe potassium chloride co-transporter 2 (KCC2) is the principal Cl− extrusion mechanism employed by mature neurons in the central nervous system (CNS) and plays a critical role in determining the efficacy of fast synaptic inhibition mediated ...
Jinglin Ji, Catherine Choi, Christopher E. Bope, Jacob S. Dengler, Stephen J. Moss, Joshua L. Smalley   +5 more
doaj   +1 more source

Changes of cochlear function during cochlear fluids manipulations [PDF]

, 2015
Spatial origins of compound action potential responses to varying stimulation rates, frequencies, and levels were investigated. A technique to measure the regions in the cochlea generating each response in which a neurotoxic drug (kainic acid) is slowly ...
Donovan, Kathryn Marie
core   +1 more source

Dopamine receptor stimulation and striatal kainic acid neurotoxicity

Journal of Pharmacy and Pharmacology, 1981
P R, Sanberg, I, Creese
openaire   +2 more sources