Interplay Among Synaptic Glutamate Release and Excitotoxicity: Neuronal Damage and Graphene-Based Materials Related Protection. [PDF]
Life (Basel)Cellot G, Ballerini L.
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Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models. [PDF]
Mol AutismPollali E +7 more
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Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-induced neurodegeneration. [PDF]
PLoS OneArimura N +10 more
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The Lateral Habenula Is Necessary for Maternal Behavior in the Naturally Parturient Primiparous Mouse Dam. [PDF]
eNeuroBenedict J +4 more
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The ontogeny of excitatory amino acid receptors in the rat forebrain--II. Kainic acid receptors.
Neuroscience, 1990The ontogeny of [3H]kainic acid binding in rat forebrain was studied quantitatively using in vitro receptor autoradiography. Specific binding was detectable in ventral thalamus, hippocampus, striatum and olfactory bulb by postnatal day 1. In regions with high densities of receptors in adulthood, such as CA3, dentate gyrus and striatum, binding ...
L. Miller +4 more
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Loss of striatal dopaminergic receptors after intrastriatal kainic acid injection.
Life Sciences, 1978Abstract Lesioning of the rat striatum with kainic acid may provide a useful animal model with which to study Huntington's Disease since, in both situations, changes in several neurochemical parameters appear similar. In this study, we examined the time course of dopaminergic (DA) and muscarinic cholinergic (MCHOL) receptor alterations after kainic ...
J. Fields, T. Reisine, Henry I. Yamamura
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The activation of glutamate receptors by kainic acid and domoic acid.
Natural Toxins, 1998The neurotoxins kainic acid and domoic acid are potent agonists at the kainate and alphaamino-5-methyl-3-hydroxyisoxazolone-4-propionate (AMPA) subclasses of ionotropic glutamate receptors. Although it is well established that AMPA receptors mediate fast excitatory synaptic transmission at most excitatory synapses in the central nervous system, the ...
D. Hampson, Jerrie Lynn Manalo
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Methyltetrahydrofolate is a potent and selective agonist for kainic acid receptors
Nature, 1980Kainic acid, a dicarboxylic acid containing pyrrolidine, is a potent neuronal depolarizing agent in the mammalian central nervous system, being some 50 times more effective than the putative neurotransmitter L-glutamate1–5. As kainic acid is a structural analogue of glutamic acid, it has been proposed that the potent excitatory effects of kainate ...
A. Ruck +3 more
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Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors
Nature, 1982Kainic acid (KA), a conformationally restricted analogue of glutamic acid, exhibits potent neuroexcitatory1 and neurotoxic properties2. The mechanism of the neurotoxicity of KA, however, seems to be complex and indirect because in many brain areas neuronal vulnerability requires the integrity of excitatory afferents3–6. Nevertheless, neurophysiological
J. Ferkany, R. Zaczek, J. Coyle
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Effects of kainic acid on the glutamate receptors of the crayfish muscle.
Neuropharmacology, 1975The effect of kainic acid on the action of l-glutamate on the crayfish muscle was investigated. l-Glutamate was applied iontophoretically and potential changes were recorded intracellularly. Kainic acid was then added to the bath solution. When the peak time of the glutamate potential was less than about 50–100 msec, kainic acid (10−4 M) had little or ...
A. Takeuchi, K. Onodera
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