Results 181 to 190 of about 15,962 (236)
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KAINIC ACID ACTIVATES OXYTOCINERGIC NEURONS THROUGH NON-NMDA GLUTAMATE RECEPTORS
International Journal of Neuroscience, 2006The present study assessed if kainic acid activates oxytocinergic neurons and this activation is blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Dual immunohistochemistry for oxytocin and c-Fos showed that oxytocin neurons in SON and PVN express c-Fos following kainic acid administration, a significant increase when compared to the control ...
Eyigor, ÖZHAN +2 more
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Loss of striatal dopaminergic receptors after intrastriatal kainic acid injection
Life Sciences, 1978Abstract Lesioning of the rat striatum with kainic acid may provide a useful animal model with which to study Huntington's Disease since, in both situations, changes in several neurochemical parameters appear similar. In this study, we examined the time course of dopaminergic (DA) and muscarinic cholinergic (MCHOL) receptor alterations after kainic ...
J Z, Fields, T D, Reisine, H I, Yamamura
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A physiologically active kainic acid-preferring receptor in chicken retina
Neuroscience Letters, 1984Neurotoxicity induced by intravitreal injections of kainic acid in the chicken retina was effectively antagonized by piperidine 2,3-dicarboxylic acid and to a lesser extent D-gamma-glutamylglycine. 2-Amino-5-phosphonovaleric acid and glutamic acid diethyl ester were much less effective antagonists. These effects probably result from interactions with a
I G, Morgan, D R, Dvorak
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The ontogeny of excitatory amino acid receptors in the rat forebrain—II. Kainic acid receptors
Neuroscience, 1990The ontogeny of [3H]kainic acid binding in rat forebrain was studied quantitatively using in vitro receptor autoradiography. Specific binding was detectable in ventral thalamus, hippocampus, striatum and olfactory bulb by postnatal day 1. In regions with high densities of receptors in adulthood, such as CA3, dentate gyrus and striatum, binding ...
L P, Miller +3 more
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Kainic Acid‐Induced Decrease in Hippocampal Corticosteroid Receptors
Journal of Neurochemistry, 1992Abstract: The potential role of excitatory amino acids in the regulation of brain corticosteroid receptors was examined using systemic administration of kainic acid. Administration of kainic acid (5, 10, and 15 mg/kg) to 24‐h adrenalectomized rats that were killed 3 h later produced large, dose‐related decreases in glucocorticoid receptors (GR) in ...
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Domoic acid: A dementia-inducing excitotoxic food poison with kainic acid receptor specificity
Experimental Neurology, 1990Domoic acid (Dom), a rigid analog of the excitotoxic amino acids, glutamate and kainic acid, is believed to be the mussel neurotoxin responsible for a recent food poisoning incident in Canada that killed some people and left others with memory impairment.
G R, Stewart +3 more
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Kainic acid lesions decrease striatal dopamine receptors and 1,4-dihydropyridine sites
Neuroscience Letters, 1988The effects of intrastriatal injection of kainic acid (2 microliters, 1 mg/ml) in the rat were determined. Four weeks after the lesioning, striatal dopamine receptors and 1,4-dihydropyridine sites were measured by radioligand binding with [3H]spiperone and [3H]nimodipine, respectively.
A, Skattebøl +3 more
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Kainic Acid: Insights Into Its Receptor-Mediated Neurotoxic Mechanisms
1983Historically, kainic acid (KA) was selected as a potential exitotoxin because the evidence at the time was consistent with the notion that, as a conformationally restricted analogue of L-glutamate, it was a potent agonist at glutamate receptors (Olney et al., 1974; Coyle and Schwarcz, 1976). Since the first reports of the perikaryal-specific neurotoxic
J. T. Coyle +4 more
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Analogue interactions with the brain receptor labeled by [3H]kainic acid
Brain Research, 1983The kinetics of interaction of kainic acid analogues and reputed antagonists of acidic excitatory amino acids with a specific binding site for [3H]alpha-kainic acid were examined in washed cerebellar membranes incubated at 4 degrees C. The avidity of both L-glutamate (1.5 microM) and quisqualate (0.6 microM) suggests that proper orientation of the two ...
J T, Slevin, J F, Collins, J T, Coyle
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Endothelin receptors in kainic acid-induced neural lesions of rat brain
Neuroscience, 1997Seven days after an intracerebroventricular injection of 0.8 microgram kainic acid, a time of neural tissue-repair after damage, we applied our receptor autoradiographic method to examine changes in the endothelin receptors in kainic acid-induced neural lesions of the rat brain. There were belt-shaped areas with the de novo expressed [125I]endothelin-1
Y, Sakurai-Yamashita +7 more
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