Results 191 to 200 of about 15,962 (236)
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Methyltetrahydrofolate is a potent and selective agonist for kainic acid receptors
Nature, 1980Kainic acid, a dicarboxylic acid containing pyrrolidine, is a potent neuronal depolarizing agent in the mammalian central nervous system, being some 50 times more effective than the putative neurotransmitter L-glutamate1–5. As kainic acid is a structural analogue of glutamic acid, it has been proposed that the potent excitatory effects of kainate ...
A, Ruck +3 more
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Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection
Hippocampus, 2011AbstractWe recently demonstrated that endogenous prodynorphin‐derived peptides mediate anticonvulsant, antiepileptogenic and neuroprotective effects via kappa opioid receptors (KOP). Here we show acute and delayed neurodegeneration and its pharmacology after local kainic acid injection in prodynorphin knockout and wild‐type mice and neuroprotective ...
Eduard, Schunk +5 more
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Fructose ingestion modifies NMDA receptors and exacerbates the seizures induced by kainic acid
Neuroscience Letters, 2022Fructose ingestion elicits a diversity of brain alterations, but it is unknown how it affects N-methyl-D-Aspartate receptors (NMDAr). Here, we analyzed the expression of NMDAr subunits and protein kinases after the long-term dietary fructose intake.
Josué, Sánchez-Hernández +3 more
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Effects of kainic acid on the glutamate receptors of the crayfish muscle
Neuropharmacology, 1975The effect of kainic acid on the action of l-glutamate on the crayfish muscle was investigated. l-Glutamate was applied iontophoretically and potential changes were recorded intracellularly. Kainic acid was then added to the bath solution. When the peak time of the glutamate potential was less than about 50–100 msec, kainic acid (10−4 M) had little or ...
A, Takeuchi, K, Onodera
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Phylogenetic distribution of [3H]kainic acid receptor binding sites in neuronal tissue
Brain Research, 1980The phylogenetic distribution of specific binding sites for kainic acid was determined in 14 species including invertebrates and vertebrates. The highest level of binding was observed in brains of the frog (Xenopus laevis), followed by the spiny dogfish (Heterodontus francisci), the goldfish (Carasius auratus) and the chick (Gallus domesticus ...
E D, London, N, Klemm, J T, Coyle
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Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia
Phytochemistry, 1995S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.
M, Andersson +7 more
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Neurochemistry International, 1987
Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the left when [Ca(2+)] was lowered to 0 ...
VERSACE, PAOLA +3 more
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Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the left when [Ca(2+)] was lowered to 0 ...
VERSACE, PAOLA +3 more
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Autoradiographic visualization of [3H]kainic acid receptor subtypes in the rat hippocampus
Neuroscience Letters, 1983Unfixed, slide-mounted tissue sections from the rat forebrain have been incubated in the presence of 20 and 100 nM [3H]kainic acid ([3H]KA). For the last 2 min of incubation, 10 micrometers unlabelled KA was added to displace [3H]KA from binding sites with high on-off rate. Washed and dried slices were exposed on [3H]Ultrofilm for 178 days. Our results
M, Berger, Y, Ben-Ari
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Kainic acid receptors and neurotoxicity in adult and immature rat cerebellar slices
Neuroscience, 1982The neurotoxic actions of kainate were examined in incubated slices of adult and immature rat cerebellum using light- and electron-microscopy. In the adult, Purkinje cells and inhibitory interneurones became selectively necrotic at concentrations between 5 micro M and 20 micro M. At 30 micro M, granule cells also became affected.
J, Garthwaite, G P, Wilkin
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Subtype selective kainic acid receptor agonists: Discovery and approaches to rational design
Medicinal Research Reviews, 2008Abstract(S)‐Glutamic acid (Glu) is the major excitatory neurotransmitter in the mammalian central nervous system, activating the plethora of glutamate receptors (GluRs). In broad lines, the GluRs are divided into two major classes: the ionotropic Glu receptors (iGluRs) and the metabotropic Glu receptors (mGluRs).
Bunch, Lennart, Krogsgaard-Larsen, Povl
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