Results 171 to 180 of about 341,836 (251)
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Autoradiographic localisation of NMDA, quisqualate and kainic acid receptors in human spinal cord.
Neuroscience Letters, 1990The phencyclidine (PCP) binding site of the N-methyl-D-aspartate receptor, the kainic acid (KA) receptor and the quisqualate (QA) receptor were visualised, using autoradiography in the human spinal cord and the distributions compared with that of benzodiazepine (BDZ) receptors and substance P (SP).
K. Jansen +3 more
semanticscholar +3 more sources
Altered expression of NPY-Y1 receptors in kainic acid induced epilepsy in rats.
Neuroscience Letters, 1997Kainic acid-induced limbic seizures cause lasting increases in neuropeptide Y (NPY) expression in hippocampal granule cells/mossy fibers. The expression of NPY-Y1 receptors in these neurons were investigated, using in situ hybridization for Y1 mRNA and receptor autoradiography with the Y1-specific ligand [125I][Pro34]PYY.
N. Kofler +3 more
semanticscholar +3 more sources
Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors
Nature Medicine, 1997Neuropeptide Y (NPY) is widely distributed in interneurons of the central nervous system (CNS), including the hippocampus and cerebral cortex, in concentrations exceeding those of any other known neuropeptides. Sequence data comparing different species show that NPY is highly conserved.
D. Woldbye +5 more
semanticscholar +3 more sources
Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia.
Phytochemistry, 1995S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.
M. Andersson +7 more
semanticscholar +3 more sources
KAINIC ACID ACTIVATES OXYTOCINERGIC NEURONS THROUGH NON-NMDA GLUTAMATE RECEPTORS
International Journal of Neuroscience, 2006The present study assessed if kainic acid activates oxytocinergic neurons and this activation is blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Dual immunohistochemistry for oxytocin and c-Fos showed that oxytocin neurons in SON and PVN express c-Fos following kainic acid administration, a significant increase when compared to the control ...
Fatma Zehra Minbay +2 more
semanticscholar +4 more sources
Endothelin receptors in kainic acid-induced neural lesions of rat brain.
Neuroscience, 1997Seven days after an intracerebroventricular injection of 0.8 microgram kainic acid, a time of neural tissue-repair after damage, we applied our receptor autoradiographic method to examine changes in the endothelin receptors in kainic acid-induced neural lesions of the rat brain. There were belt-shaped areas with the de novo expressed [125I]endothelin-1
Y. Sakurai‐Yamashita +7 more
semanticscholar +3 more sources
Kainic acid receptors and neurotoxicity in adult and immature rat cerebellar slices.
Neuroscience, 1982The neurotoxic actions of kainate were examined in incubated slices of adult and immature rat cerebellum using light- and electron-microscopy. In the adult, Purkinje cells and inhibitory interneurones became selectively necrotic at concentrations between 5 micro M and 20 micro M. At 30 micro M, granule cells also became affected.
J. Garthwaite, G. Wilkin
semanticscholar +3 more sources
Brain Research, 1990
The distributions of N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-S-methyl-4-isoxazole propionic acid (AMPA) and kainic acid (KA) receptors were determined in the human cerebellum using autoradiography. In contrast to the cerebral cortex, where KA receptors have a complementary distribution to NMDA and AMPA receptors, AMPA receptors were ...
K. Jansen, R. Faull, M. Dragunow
semanticscholar +3 more sources
The distributions of N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-S-methyl-4-isoxazole propionic acid (AMPA) and kainic acid (KA) receptors were determined in the human cerebellum using autoradiography. In contrast to the cerebral cortex, where KA receptors have a complementary distribution to NMDA and AMPA receptors, AMPA receptors were ...
K. Jansen, R. Faull, M. Dragunow
semanticscholar +3 more sources
Kainic acid and the glutamate receptor
Neuroscience Letters, 1978Abstract The excitatory effects of microelectrophoretically administered kainic (KAIN) and glutamic (GLUT) acids have been compared on central neurones of the rat in the presence of antagonists of amino acid-induced excitations. Antagonism by both D-α-amino adipic acid (DAA) and glutamic acid diethyl ester (GDEE) of the effects of glutamic acid but ...
Hall, J., Hicks, T., Mclennan, H.
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Retinal benzodiazepine receptors are destroyed by kainic acid lesions
Neuroscience Letters, 1980[3H]Diazepam binds to preparations of membranes from chicken retina. Two binding sites were detected; a high affinity site (KD, 1.8 nM and Bmax, 0.17 pmol/mg retina protein) and a low affinity site (KD, 132 nM and Bmax, 1.46 pmol/mg retinal protein). GABA stimulated [3H]diazepam binding to these retinal membranes.
M, Willow, I G, Morgan
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