Results 71 to 80 of about 341,836 (251)

Pathologically Activated Neuroprotection via Uncompetitive Blockade of \u3cem\u3eN\u3c/em\u3e-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin [PDF]

, 2010
Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders.
Fu, Hongjun, Han, Yifan, Huang, Pingbo, Li, Chaoying, Li, Fushun, Li, Wenming, Luo, Jialie, Ma, Dik-Lung, Pang, Yuanping, Peoples, Robert W., Tang, Jing, Wang, Qinwen, Xia, Jun, Zhao, Yuming   +13 more
core   +1 more source

3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility [PDF]

, 2015
Kainic acid (KA) causes seizures and neuronal loss in the hippocampus. The present study investigated whether a recreational schedule of 3,4-methylenedioxymethamphetamine (MDMA) favours the development of a seizure state in a model of KA-induced epilepsy
Abad, Sonia, Auladell i Costa, M. Carme, Camarasa García, Jordi, Camins Espuny, Antoni, Escubedo Rafa, Elena, Junyent Herena, Fèlix, Pallàs i Llibería, Mercè, 1964-, Pubill Sánchez, David   +7 more
core   +2 more sources

Fucoxanthin Inhibits the NMDA and AMPA Receptors Through Regulating the Calcium Response on Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Juvenile Mice

Neural Plasticity
Glutamate excitotoxicity is considered as the etiology of stroke and neurodegenerative diseases, namely, Parkinson’s disease (PD), Alzheimer’s disease (AD), and others.
Nhung Ha Thuy Le, Seon Ah Park, Yu Mi Kim, Dong Kuk Ahn, Won Jung, Seong Kyu Han   +5 more
doaj   +1 more source

Calcineurin-mediated GABAA receptor dephosphorylation in rats after kainic acid-induced status epilepticus [PDF]

Seizure, 2009
Calcineurin (CaN) is a neuronally enriched, calcium-dependent phosphatase, which plays an important role in a number of neuronal processes including development of learning and memory, and modulation of receptor's function and neuronal excitability as well as induction of apoptosis. It has been established in kindling model that the status epilepticus (
Wang, Aihua, Chi, Zhaofu, Wang, Shengjun, Wang, Shuhua, Sun, Qinjian   +4 more
openaire   +2 more sources

p75, but Not proNGF, Is Upregulated Following Status Epilepticus in Mice

ASN Neuro, 2014
ProNGF and p75 NTR are upregulated and induce cell death following status epilepticus (SE) in rats. However, less is known about the proneurotrophin response to SE in mice, a more genetically tractable species where mechanisms can be more readily ...
Melissa W. VonDran, John LaFrancois, Victoria A. Padow, Wilma J. Friedman, Helen E. Scharfman, Teresa A. Milner, Barbara L. Hempstead   +6 more
doaj   +1 more source

A latent serotonin-1A receptor-gated spinal afferent pathway inhibiting breathing [PDF]

, 2015
Spinal afferents such as nociceptive afferents and group III–IV muscle afferents are known to exert an acute excitatory effect on breathing when activated. Here, we report the surprising existence of latent spinal afferents which exerted tonic inhibitory
Ning, Yinghui, Poon, Chi-Sang, Song, Gang, Yang, Liang   +3 more
core   +1 more source

Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor function [PDF]

Brain Research, 2010
The pathophysiology of schizophrenia may involve reduced NMDA receptor function and experimental models of NMDA receptor hypofunction have proven useful for characterizing neurobiological abnormalities potentially relevant to schizophrenia. The present study assessed behavioral responses and induction of Fos after administration of kainic acid to wild ...
Gary E, Duncan, Ken, Inada, Beverly H, Koller, Sheryl S, Moy   +3 more
openaire   +2 more sources

Pharmacological preconditioning with GYKI 52466: a prophylactic approach to neuroprotection

Frontiers in Neuroscience, 2010
Some toxins and drugs can trigger lasting neuroprotective mechanisms that enable neurons to resist a subsequent severe insult. This ‘pharmacological preconditioning’ has far-reaching implications for conditions in which blood flow to the ...
Chelsea S Goulton, Anna R Patten, John R Kerr, Steve Kerr   +3 more
doaj   +1 more source

Modulation of the Expression of the GABAA Receptor β1 and β3 Subunits by Pretreatment with Quercetin in the KA Model of Epilepsy in Mice -The Effect of Quercetin on GABAA Receptor Beta Subunits- [PDF]

, 2016
Objectives: Quercetin is a flavonoid and an important dietary constituent of fruits and vegetables. In recent years, several pharmacological activities of quercetin, such as its neuroprotective activity and, more specifically, its anti-convulsant effects
Khodabandehloo, Fatemeh, Moghbelinejad, Sahar, Mohammadi, Ghazaleh, Nassiri-Asl, Marjan, Rashvand, Zahra   +4 more
core   +2 more sources

A kainic acid receptor from frog brain purified using domoic acid affinity chromatography.

Journal of Biological Chemistry, 1988
A kainic acid receptor was purified from Triton X-100/digitonin-solubilized frog brain membranes. The purification was carried out in two steps: ion exchange chromatography using DEAE-Sepharose CL-6B and affinity chromatography with domoic acid immobilized on Sepharose 4B.
D R, Hampson, R J, Wenthold
openaire   +2 more sources