Results 81 to 90 of about 341,836 (251)

Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure

Neurobiology of Disease, 2016
Neonatal seizures are associated with long term disabilities including epilepsy and cognitive deficits. Using a neonatal seizure rat model that does not develop epilepsy, but develops a phenotype consistent with other models of intellectual disability ...
Heather O'Leary, Paul B. Bernard, Anna M. Castano, Tim A. Benke   +3 more
doaj   +1 more source

CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility

Neurobiology of Disease, 2017
Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders accompanied by intractable epilepsies, i.e. West syndrome or atypical Rett syndrome.
Kosuke Okuda, Shizuka Kobayashi, Masahiro Fukaya, Aya Watanabe, Takuto Murakami, Mai Hagiwara, Tempei Sato, Hiroe Ueno, Narumi Ogonuki, Sayaka Komano-Inoue, Hiroyuki Manabe, Masahiro Yamaguchi, Atsuo Ogura, Hiroshi Asahara, Hiroyuki Sakagami, Masashi Mizuguchi, Toshiya Manabe, Teruyuki Tanaka   +17 more
doaj   +1 more source

Interferon-α2b Modulates AMPA and Kainate Receptors and Alters Cross Talk of AMPA and NMDA Receptors in the Frog Vestibular Epithelium

Frontiers in Bioscience-Landmark
Background: Interferons (IFNs) are ototoxic drugs leading to vestibular and auditory disorders. This study investigated the effect of pro-inflammatory cytokine IFN-α2b on the afferent glutamatergic synaptic transmission of the ...
Irina V. Ryzhova, Elena A. Vershinina, Alexander G. Markov, Tatyana V. Tobias   +3 more
doaj   +1 more source

Submicromolar copper (II) ions stimulate transretinal signaling in the isolated retina from wild type but not from Cav2.3-deficient mice

BMC Ophthalmology, 2020
Background So far, only indirect evidence exists for the pharmacoresistant R-type voltage-gated Ca2+ channel (VGCC) to be involved in transretinal signaling by triggering GABA-release onto ON-bipolar neurons.
Jan Niklas Lüke, Felix Neumaier, Serdar Alpdogan, Jürgen Hescheler, Toni Schneider, Walid Albanna, Isha Akhtar-Schäfer   +6 more
doaj   +1 more source

Changes of cochlear function during cochlear fluids manipulations [PDF]

, 2015
Spatial origins of compound action potential responses to varying stimulation rates, frequencies, and levels were investigated. A technique to measure the regions in the cochlea generating each response in which a neurotoxic drug (kainic acid) is slowly ...
Donovan, Kathryn Marie
core   +1 more source

Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus [PDF]

, 2005
Persistent activation of GABAA receptors by extracellular GABA (tonic inhibition) plays a critical role in signal processing and network excitability in the brain.
Kullmann, D.M., Scimemi, A., Semyanov, A., Sperk, G., Walker, M.C.   +4 more
core   +1 more source

Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. [PDF]

, 1999
Febrile (fever-induced) seizures affect 3-5% of infants and young children. Despite the high incidence of febrile seizures, their contribution to the development of epilepsy later in life has remained controversial.
Baram, TZ, Chen, K, Soltesz, I
core   +1 more source

Neuroprotective actions of ghrelin and growth hormone secretagogues [PDF]

, 2011
The brain incorporates and coordinates information based on the hormonal environment, receiving information from peripheral tissues through the circulation.
Laura M. Frago, Laura M. Frago, Laura M. Frago, Laura M. Frago, Eva eBaquedano, Eva eBaquedano, Eva eBaquedano, Eva eBaquedano, Jesús eArgente, Jesús eArgente, Jesús eArgente, Jesús eArgente, Julie A Chowen, Julie A Chowen, Julie A Chowen   +14 more
core   +1 more source

Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures [PDF]

, 2019
The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites.
Andrews, Peter M., Brandon, Nicholas J., Davies, Paul A., Hines, Rochelle M., Moore, Yvonne E., Moss, Stephen J., Nathanson, Anna J., Ollerhead, Thomas A., Rodriguez Santos, Miguel A., Smalley, Joshua L., Wobst, Heike J., Zhang, Yihui   +11 more
core   +2 more sources

Serotonin receptor antagonists increase fast ripple activity in rats treated with kainic acid

Brain Research Bulletin, 2016
Fast ripples (FR, 250-600 Hz) are field potentials that occur only in those areas capable of generating seizures, such as the hippocampus, and modulation of FR by serotonin has been reported. Therefore, we hypothesized that the receptor antagonists 5HT1A and 5HT2A, B, C will increase FR in rats treated with kainic acid (KA, 0.8 μg/0.5 μl).
Carla, García-Barba, Laura, Medina-Ceja
openaire   +2 more sources