Results 251 to 260 of about 77,479 (303)

The VLDL receptor: wayward brother of the LDL receptor

Current Opinion in Lipidology, 1995
The VLDL receptor binds lipoproteins that contain apolipoprotein E and consists of five functional domains that resemble the LDL receptor. Although the LDL- and VLDL-receptor genes are located on different chromosomes, their gene structure and organization are almost the same.
H, Jingami, T, Yamamoto
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LDL receptor polymorphisms revisited

Blood, 2010
In this issue of Blood , Martinelli and colleagues describe that certain single-nucleotide polymorphisms in the LDL receptor gene independently associate with high plasma levels of coagulation factor VIII in patients with coronary artery disease.[1][1] In 1985, Drs M. S. Brown and J.
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LDL-receptor

2000
Opisan je značaj LDL-receptora u metabolizmu kolesterola te metoda protočne citometrije s pomoću koje se može dobiti uvid u relativnu aktivnost LDL-receptora na površini kultiviranih monocita.
Užarević, Branka, Zrinski Topić, Renata   +1 more
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Expression of LDL receptor and uptake of LDL in mouse preimplantation embryos

Molecular and Cellular Endocrinology, 2003
The aim of this study is to address the role of low-density lipoprotein (LDL) on mouse preimplantation embryos.The temporal expression of low-density lipoprotein receptor (LDLR) and side-chain cleavage cytochrome P450 (P450scc) mRNAs in mouse oocytes and preimplantation embryos up to the hatched blastocyst stage were analyzed by RT-PCR and nested PCR ...
N, Sato, K, Kawamura, J, Fukuda, Y, Honda, T, Sato, H, Tanikawa, H, Kodama, T, Tanaka   +7 more
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LDL Receptor's β-Propeller Displaces LDL

Science, 2002
The low density lipoprotein receptor (LDLR) binds to lipoprotein extracellularly and releases it in the endosome. In his Perspective, Innerarity discusses new structural work (Rudenkoet al.) that shows that an interdomain interaction that occurs at low pH likely displaces ligand from the receptor in the endosome.
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[LDL receptors].

Revue medicale de Bruxelles, 1991
The low density lipoprotein receptor removes the cholesterol-carrying lipoproteins from blood. When the activity of LDL receptors is reduced, as a result of genetic or acquired abnormalities, LDL increases in blood, resulting in atherosclerosis. Heterozygote familial hypercholesterolemia (one mutant gene) is characterized by a 50% reduction of LDL ...
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Governance of the concentration of plasma LDL: a reevaluation of the LDL receptor paradigm

Atherosclerosis, 2000
The level of LDL in plasma is the major determinantof the risk of vascular disease and lowering the level ofLDL diminishes that risk, both in those with and thosewithout symptomatic vascular disease [1–4]. Fully un-derstanding the factors that govern the concentration ofplasma LDL is, therefore, one of our most importantchallenges.
A D, Sniderman, X J, Zhang, K, Cianflone
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Solution Structure of the Sixth LDL-A Module of the LDL Receptor^,

Biochemistry, 2000
The low-density lipoprotein receptor (LDLR) is the primary mechanism for uptake of plasma cholesterol into cells and serves as a prototype for an entire class of cell surface receptors. The amino-terminal domain of the receptor consists of seven LDL-A modules; the third through the seventh modules all contribute to the binding of low-density ...
C L, North, S C, Blacklow
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Lowering LDL cholesterol, but not raising LDL receptor activity, by ezetimibe

Journal of Clinical Lipidology, 2013
Ezetimibe, an inhibitor of intestinal cholesterol absorption, is effective in lowering serum low-density lipoprotein (LDL) cholesterol with or without coadministration of statin. Ezetimibe-plus-statin therapy enhances LDL receptor activity, but it is still unclear whether ezetimibe alone enhances LDL receptor activity, resulting in LDL cholesterol ...
Hiroshi, Hayashi, Mitsunobu, Kawamura
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Regulation of LDL Receptors in vivo

1984
The information reviewed here indicates that LDL receptor activity in vivo is regulated in normal animals and probably in normal humans. Furthermore, LDL receptor activity is also regulated in patients with heterozygous Familial Hypercholesterolemia. Our experiments in patients with this disease indicate that one can exploit the normal regulation of ...
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