Results 121 to 130 of about 2,265,539 (159)

LHRH RECEPTORS AND LHRH RECEPTOR-BEARING CELLS IN PITUITARIES OF STREPTOZOCIN DIABETIC MALE RATS

Pharmacological Research, 1997
Streptozocin (STZ)-diabetic rats have low hypothalamic luteotropic hormone-releasing hormone (LHRH) secretion and various alterations of gonadotrope cells, among which low luteotropic hormone (LH) secretion. Possible causes for the gonadotrope disorders may be low hypothalamic LHRH secretion alone or combined with reduced (a) number of LHRH receptor ...
Bernhard Moser, C.E. Boujon, Alfred Walz, Gilberto E. Bestetti, Giovanni L. Rossi, Annamaria Brändli-Baiocco, D. Barone   +6 more
openaire   +3 more sources

Variations in the number of pituitary LHRH receptors correlated with altered responsiveness to LHRH

Life Sciences, 1982
Isolated pituitary cells from metestrous, ovariectomized (OVX), and ovariectomized-estradiol treated (OVX-EB) rats were employed to study the gonadotrophin response to luteinizing hormone-releasing hormone (LHRH) challenge and to quantitate LHRH receptors, using a labeled LHRH analog.
Nurit Ben Aroya, R. Meidan, Yitzhak Koch
openaire   +3 more sources

Inhibin Interaction with LHRH Receptors at the Pituitary Level

Archives of Andrology, 1982
In order to investigate whether inhibin could modulate the action of luteinizing hormone releasing hormone (LHRH), the in vitro effect of inhibin of LHRH bindings to the pituitaries from intact adult male rats was studied. The inhibin preparations suppressed the binding of labeled LHRH to pituitary receptors in a dose-related manner.
P. R. Sheth, N. Seethalakshmi, Anil R. Sheth, S. P. Dandekar   +3 more
openaire   +3 more sources

CRF alters the infundibular LHRH secretory system from the medial preoptic area of female rats: possible involvement of opioid receptors.

Neuroendocrinology, 1993
Corticotropin-releasing factor (CRF) is a potent factor involved in the antireproductive effects of various stressors. However, the central mechanisms by which CRF modulates the hypothalamic-pituitary-gonadal (HPG) axis are not well understood.
S. Rivest, P. Plotsky, C. Rivier
semanticscholar   +1 more source

LHRH Receptor Targeted Therapy for Breast Cancer

2008
Breast cancer remains the most common cancer among women, with an estimated 212,920 new cases and 40,970 deaths in the United States in 2006. The present work extends the studies of nanoparticles targeted to the luteinizing hormone-releasing hormone (LHRH) receptor which is overexpressed in breast, ovarian, endometrial and prostate cancer cells.
John W. Eaton, Kyung A. Kang, Bin Hong, Shelly Kakar, Hanzhu Jin   +4 more
openaire   +3 more sources

Receptor-mediated internalization of LHRH antagonists by pituitary cells

Molecular and Cellular Endocrinology, 1983
A fluorescently labeled antagonist of luteinizing hormone releasing hormone (LHRH), D-pGlu-D-Phe-D-Trp-Ser-Tyr-D-Lys6-(tetramethylrhodamine)-Leu-Arg-Pro-Gly-NH2, was prepared. This peptide retained high-affinity binding to the LHRH receptor of pituitary plasma membrane preparations.
Hans R. Lindner, R. Meidan, Yitzhak Koch, Dana Keinan, Eli Hazum, Mordechai Liscovitch   +5 more
openaire   +3 more sources

LHRH receptor expression in sarcomas of bone and soft tissue

Hormone Molecular Biology and Clinical Investigation, 2016
Abstract Aim: Luteinizing hormone releasing hormone (LHRH) is a neurohormone, secreted by the hypothalamus, which regulates the secretion of gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary.
Andrew V. Schally, Philip Robinson, H. Thomas Temple, Norman L. Block, Chenthuran Deivaraju   +4 more
openaire   +3 more sources

Effects of an LHRH agonist and gonadotropins on testicular prolactin receptors

Peptides, 1982
Effects of administration of the LHRH agonist D-Leu6-LHRH ethylamide (LHRH-A), gonadotropin (PMS), and their interaction on testicular prolactin (PRL) receptor levels were investigated in rats. LHRH-A (2 micrograms/100 g body wt.) or saline was injected SC daily, and PMS (5 IU) injected every other day.
C.M. Turkelson, C.M. Turkelson, A. Arimura, A. Arimura, J.B. Fishback   +4 more
openaire   +3 more sources

Dissociated changes of pituitary luteinizing hormone-releasing hormone (LHRH) receptors and responsiveness to the neurohormone induced by 17 beta-estradiol and LHRH in vivo in the rat.

Endocrinology, 1981
A single injection of 17 beta-estradiol into castrated male or female rats results in an initial decrease in plasma concentrations of LH and pituitary responsiveness to LHRH, followed by a rapid return to normal or slightly elevated values.
L. Ferland, B. Marchetti, C. Séguin, F. Lefebvre, J. Reeves, F. Labrie   +5 more
semanticscholar   +1 more source

Abstract 5476: LHRH receptor targeting as mechanism of anti-tumor activity for cytotoxic conjugates of Disorazol Z with the LHRH receptor agonistic peptide D-Lys6-LHRH.

Cancer Research, 2013
Abstract Background For drug-targeting aimed at the treatment of LHRH receptor overexpressing cancers the LHRH receptor agonistic peptide D-Lys6-LHRH has been conjugated to the novel highly cytotoxic natural compound Disorazol Z.
Lars Blumenstein, Olaf Ortmann, Antje Schubert, Michael Teifel, J. Engel, Babette Aicher, Rolf Mueller, Tilmann Schuster, Carsten Gründker, Eckhard Guenther, Matthias Gerlach   +10 more
openaire   +2 more sources