Results 11 to 20 of about 2,265,539 (159)

Locally Expressed LHRH Receptors Mediate the Oncostatic and Antimetastatic Activity of LHRH Agonists on Melanoma Cells [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2002
Malignant melanoma is a tumor known for its uncontrollable growth and aggressive metastatic behavior. The mean survival time for patients with a metastatic melanoma is estimated to be less than 6 months, tumor cells being refractory to the conventional chemotherapy.
R.M. Moretti, M. Montagnani Marelli, J. C. Van Groeninghen, P. Limonta   +3 more
openaire   +5 more sources

AEZS-108: a targeted cytotoxic analog of LHRH for the treatment of cancers positive for LHRH receptors

Expert Opinion on Investigational Drugs, 2012
Receptors for the luteinizing hormone-releasing hormone [LHRH, also known as gonadotropin-releasing hormone (GnRH)] can be regarded as an ideal target for a personalized medicine approach in cancer therapy. LHRH receptors are expressed in about 80% of human endometrial and ovarian cancers, 86% of prostate cancer, and about 50% of breast cancers ...
Engel, Joerg B., Emons, Guenter, Pinski, Jacek, Schally, Andrew V.   +3 more
openaire   +5 more sources

Comparison of mechanisms of action of luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats [PDF]

Proceedings of the National Academy of Sciences, 2001
The mechanisms through which luteinizing hormone (LH)-releasing hormone (LHRH) antagonists suppress pituitary gonadotroph functions and LHRH-receptor (LHRH-R) expression are incompletely understood. Consequently, we investigated the direct effect of LHRH antagonist cetrorelix in vitro on the expression of the ...
Magdolna Kovacs, Andrew V. Schally, Andrew V. Schally   +2 more
openaire   +3 more sources

Changes in pituitary and ovarian LHRH receptors after active immunization of female rats against LH or LHRH [PDF]

Reproduction, 1985
The hypothalamic-pituitary-ovarian axis of female rats was disrupted at the site of LHRH stimulation by active immunization against LHRH or at the site of LH action by active immunization against LH. Active immunization against LH was associated with an increase in pituitary LHRH receptors to levels comparable to control values at pro-oestrus whereas ...
R. M. Popkin, H. M. Fraser
openaire   +4 more sources

The presence of LHRH‐like receptors in Dunning R3327H prostate tumors

FEBS Letters, 1983
Quantitative analyses of LH‐RH‐like membrane receptors were performed in five tumors from the transplantable Dunning R3372H rat prostatic adenocarcinoma. The binding of D‐Trp6‐LH‐RH, an agonist of LH‐RH, was observed in all 5 tumors. The antagonist [Ac‐Dp‐Cl‐Phe1,2,D‐Trp3,D‐Lys6,D‐Ala10]‐LH‐RH was bound to 4 tumors.
Altamirano Perla, Tommie W. Redding, Marion T. Hierowski, Andrew V. Schally   +3 more
openaire   +4 more sources

Corrin Ring Modification in Peptide Drug Development - a Brief History of "Corrination". [PDF]

ChemMedChem
This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Cham N, Doyle RP.
europepmc   +2 more sources

LHRH-Conjugated Drugs as Targeted Therapeutic Agents for the Specific Targeting and Localized Treatment of Triple Negative Breast Cancer

Scientific Reports, 2020
Bulk chemotherapy and drug release strategies for cancer treatment have been associated with lack of specificity and high drug concentrations that often result in toxic side effects. This work presents the results of an experimental study of cancer drugs
J. D. Obayemi, A. Salifu, S. C. Eluu, V. Uzonwanne, S. M. Jusu, C. Nwazojie, C. Onyekanne, O. Ojelabi, L. Payne, C. Moore, J. King, W. Soboyejo   +11 more
semanticscholar   +1 more source

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma

OncoTarget, 2020
Uveal melanoma (UM) is the most common malignant tumor of the eye. Recently, we have established that 46% of UM specimens express LHRH receptors. This finding supports the idea of a LHRH receptor-targeted therapy of UM patients. Cytotoxic analog of LHRH,
Klára Fodor, Nikoletta Dobos, A. Schally, Z. Steiber, G. Oláh, É. Sipos, Lorant Szekvolgyi, G. Halmos   +7 more
semanticscholar   +1 more source

Triple negative breast cancers express receptors for LHRH and are potential therapeutic targets for cytotoxic LHRH-analogs, AEZS 108 and AEZS 125

BMC Cancer, 2014
BackgroundTriple negative breast cancer (TNBC) is a distinct subtype of breast cancer burdened with a dismal prognosis due to the lack of effective therapeutic agents.
S. Seitz, S. Buchholz, A. Schally, F. Weber, M. Klinkhammer-Schalke, E. Inwald, R. Perez, F. Rick, L. Szalontay, F. Hohla, S. Segerer, C. W. Kwok, O. Ortmann, J. Engel   +13 more
semanticscholar   +1 more source

Efficacy and Safety of AEZS-108 (LHRH Agonist Linked to Doxorubicin) in Women With Advanced or Recurrent Endometrial Cancer Expressing LHRH Receptors

International Journal of Gynecologic Cancer, 2014
Objective Advanced or recurrent endometrial cancer (EC) no longer amenable to surgery or radiotherapy is a life-threatening disease with limited therapeutic options left.
G. Emons, G. Gorchev, P. Harter, P. Wimberger, A. Stähle, L. Hanker, F. Hilpert, M. Beckmann, P. Dall, C. Gründker, H. Sindermann, J. Sehouli   +11 more
semanticscholar   +1 more source