Results 21 to 30 of about 2,265,539 (159)

Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer

Reproductive Biology and Endocrinology, 2003
The expression of GnRH (GnRH-I, LHRH) and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the ovary.
Emons Günter, Gründker Carsten
doaj   +1 more source

Triple-negative breast cancers express receptors for luteinizing hormone-releasing hormone (LHRH) and respond to LHRH antagonist cetrorelix with growth inhibition.

International Journal of Oncology, 2009
The aim of the present study was to evaluate the expression of receptors for luteinizing hormone-releasing hormone (LHRH) in human specimens of triple-negative breast cancers (TNBC). In addition, we used in vitro and in vivo models of TNBC to investigate
S. Buchholz, S. Seitz, A. Schally, J. Engel, F. Rick, L. Szalontay, F. Hohla, A. Krishan, A. Papadia, T. Gaiser, G. Brockhoff, O. Ortmann, K. Diedrich, F. Köster   +13 more
semanticscholar   +1 more source

Involvement of Membrane Progestin Receptor Beta (mPRβ/Paqr8) in Sex Pheromone Progestin-Induced Expression of Luteinizing Hormone in the Pituitary of Male Chinese Black Sleeper (Bostrychus Sinensis)

Frontiers in Endocrinology, 2018
Our previous studies showed that 17α, 20β-dihydroxy-4-pregnen-3-one (DHP) acted as a sex pheromone to induce reproductive success in Chinese black sleeper (Bostrychus sinensis), but its functional mechanism remains unclear.
Yu Ting Zhang, Wan Shu Hong, Dong Teng Liu, Heng Tong Qiu, Yong Zhu, Yong Zhu, Shi Xi Chen, Shi Xi Chen, Shi Xi Chen   +8 more
doaj   +1 more source

Synthesis and Cytotoxic Study of a Platinum(IV) Anticancer Prodrug with Selectivity toward Luteinizing Hormone-Releasing Hormone (LHRH) Receptor-Positive Cancer Cells.

Inorganic Chemistry, 2019
Platinum drugs including cisplatin are widely used in clinics to treat various types of cancer. However, the lack of cancer-cell selectivity is one of the major problems that lead to side effects in normal tissues.
Houzong Yao, Zoufeng Xu, Cai Li, M. Tse, Zixuan Tong, G. Zhu   +5 more
semanticscholar   +1 more source

Effect of long-term treatment with low doses of the LHRH antagonist Cetrorelix on pituitary receptors for LHRH and gonadal axis in male and female rats.

Proceedings of the National Academy of Sciences of the United States of America, 2004
Our previous studies showed that treatment of female rats with large doses of Cetrorelix, an antagonist of luteinizing hormone-releasing hormone (LHRH), reduces levels of serum LH, estradiol, progesterone, and the concentration of pituitary LHRH ...
J. Horváth, Gabor L. Toller, A. Schally, A. Bajo, K. Groot   +4 more
semanticscholar   +1 more source

LHRH-Targeted Drug Delivery Systems for Cancer Therapy.

Mini-Reviews in Medical Chemistry, 2017
Targeted delivery of therapeutic and diagnostic agents to cancer sites has significant potential to improve the therapeutic outcome of treatment while minimizing severe side effects. It is widely accepted that decoration of the drug delivery systems with
Xiaoning Li, O. Taratula, O. Taratula, C. Schumann, T. Minko   +4 more
semanticscholar   +1 more source

Luteinizing hormone-releasing hormone (LHRH) agonist restoration of age-associated decline of thymus weight, thymic LHRH receptors, and thymocyte proliferative capacity.

Endocrinology, 1989
The presence of specific LHRH-binding sites within the rat thymus gland and the ability of LHRH and its agonistic and antagonistic analogs to directly modulate thymus function prompted us to study the possible changes in the number of thymic LHRH-binding
Bianca Marchetti, V. Guarcello, M. C. Morale, G. Bartoloni, F. Raiti, Giuseppe A. Palumbo, Z. Farinella, S. Cordaro, Umberto Scapagnini   +8 more
semanticscholar   +1 more source

Luteinizing hormone releasing hormone (LHRH) neurons maintained in nasal explants decrease LHRH messenger ribonucleic acid levels after activation of GABA(A) receptors.

Endocrinology, 1998
Inhibition of the LHRH system appears to play an important role in preventing precocious activation of the hypothalamic-pituitary-gonadal axis. Evidence points to gamma-aminobutyric acid (GABA) as the major negative regulator of postnatal LHRH neuronal ...
S. Fueshko, S. Key, S. Wray
semanticscholar   +2 more sources

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

Impact of Concomitant Hormone Therapy on the Diagnostic Performance of 18F‐Piflufolastat PET/CT in Prostate Cancer Patients: A Sub‐Group Analysis of OSPREY Cohort B

The Prostate, EarlyView.
ABSTRACT Background This study investigates the impact of hormone therapy (HT) on the diagnostic performance of 18F‐piflufolastat PET/CT in OSPREY (NCT02981368) cohort B patients with recurrent or metastatic prostate cancer. Methods 18F‐piflufolastat PET/CT was evaluated in OSPREY cohort B patients (n = 117 men) with elevated prostate‐specific antigen (
Lawrence Saperstein, Steven P. Rowe, Michael A. Gorin, Kenneth J. Pienta, Barry A. Siegel, Michael J. Morris, Saradha Baskaran, Nancy Stambler, Vincent A. DiPippo, Bela S. Denes   +9 more
wiley   +1 more source