Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem +9 more
wiley +1 more source
Characterization of Luteinizing hormone-releasing hormone (LH-RH-I) receptor type I as a potential molecular target in OCM-1 and OCM-3 human uveal melanoma cell lines [PDF]
K
Dobos, Nikoletta +8 more
core +1 more source
A Retrospective Study on the Impact of Primary Aldosteronism in Pregnancy (H.A.P.P.I. Study Group)
ABSTRACT Objective Primary aldosteronism (PA) is a common cause of hypertension in young women. However, there is a paucity of data regarding its impact during pregnancy. The primary objective of this study was to describe the occurrence of hypertensive disorders of pregnancy (HDP) in PA.
Diana Oprea +7 more
wiley +1 more source
Lifestyle implications of the paradox and management of oxidative stress in sperm
Abstract figure legend Lifestyle factors influencing male fertility. Schematic overview of lifestyle factors with beneficial (left) and detrimental (right) effects on male fertility. A balanced diet, regular moderate physical activity and stress management strategies support sperm function and redox homeostasis.
Giuseppe T. Patané +6 more
wiley +1 more source
Rapid Nongenomic Effects of Oestradiol on Gonadotrophin‐Releasing Hormone Neurones [PDF]
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89550/1/j.1365-2826.2011.02135.x ...
Abe +45 more
core +1 more source
Metal Nanoclusters for Cancer Imaging and Treatment
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu +5 more
wiley +1 more source
Design of experiments was used to optimize docetaxel‐loaded PLGA‐PEG nanoparticles that were fabricated by nanoprecipitation using a microfluidics technique. The nanoparticles were functionalized with an antibody to target prostate‐specific membrane antigen receptor on LnCap prostate cancer cells.
Divesha Essa +2 more
wiley +1 more source
The Role of RFamide-Related Peptide-3 in Age-Related Reproductive Decline in Female Rats. [PDF]
Reproductive senescence, the point in time when females cease to show estrous cyclicity, is associated with endocrine changes in the hypothalamus, pituitary, and gonads. However, the mechanisms triggering this transition are not well understood.
Bentley, George E +4 more
core +1 more source
The endocrine system coordinates whole body cellular function and maintains homeostasis. Alcohol impacts the integrity of endocrine regulation at multiple sites, contributing to risk for comorbidities. Some of the alcohol‐mediated pathophysiological effects on the endocrine system include alterations in receptor expression and responsiveness, protein ...
Patricia E. Molina, Liz Simon
wiley +1 more source
Synthesis, characterisation and systematic comparison of FITC-labelled GnRH-I, -II and -III analogues on various tumour cells [PDF]
Targeted tumour therapy is in the focus of recent cancer research. GnRH analogues are able to deliver anticancer agents selectively into tumour cells which highly express GnRH receptors.
Bökönyi, Györgyi +9 more
core +1 more source

