Results 51 to 60 of about 3,979 (188)

Effective targeted chemotherapy using AEZS-108 (AN-152) for LHRH receptor-positive pancreatic cancers [PDF]

, 2011
Pancreatic cancer is the fourth commonest cause of cancer-related mortality across the world. Because of the poor response to conventional chemotherapy, small molecules, radiation therapy and surgery, development of new targeted therapies is necessary ...
Reutter, Madita D., Ernst, Jennifer, Emons, Guenter, Gruendker, Carsten, Ghadimi, B. Michael   +4 more
core   +1 more source

Engineered Elastin‐Like Polypeptides: Intelligent Self‐Assembling Platforms for Biomedical Application

Small Structures, Volume 7, Issue 3, March 2026.
Armed with unique structural and functional properties, elastin‐like polypeptides attract their attentions as programmable materials in biomedical applications, including fusion tags for protein and nucleic acid purification; nanocarriers for protein, chemotherapeutics, and imaging agent delivery; hydrogels for tissue regeneration, 3D model ...
Yang Yuan, Chen Zeng, Zichun Chen, Zhuoga Ciren, Qinran Yu, Chuanbo Wang, Hui Mao, Gang Li, Weizhi Chen, Xiqun Jiang   +9 more
wiley   +1 more source

LHRH-Conjugated Drugs as Targeted Therapeutic Agents for the Specific Targeting and Localized Treatment of Triple Negative Breast Cancer [PDF]

, 2020
Bulk chemotherapy and drug release strategies for cancer treatment have been associated with lack of specificity and high drug concentrations that often result in toxic side effects. This work presents the results of an experimental study of cancer drugs
Eluu, S. C., Uzonwanne, V. O., Obayemi, J. D., King, Jean A., Ojelabi, Ogooluwa, Payne, L., Salifu, A. A., Jusu, S. M., Nwazojie, C. C., Onyekanne, C. E., Soboyejo, W. O., Moore, Constance M.   +11 more
core   +1 more source

Molecular and Endocrine Regulation of Ovarian Maturation in the Black Tiger Prawn (Penaeus monodon) and Associated Challenges in Its Aquaculture

Reviews in Aquaculture, Volume 18, Issue 2, March 2026.
ABSTRACT Over the past four decades, substantial research has investigated the regulation of ovarian maturation and spawning in the black tiger prawn (Penaeus monodon). In this species, female reproduction is strongly suppressed by gonad‐inhibiting hormone (GIH) released from the eyestalk, making eyestalk ablation (ESA) the most widely adopted spawning‐
Gourab Chowdhury, Josephine Nocillado, Abigail Elizur, Scott F. Cummins, Tomer Ventura   +4 more
wiley   +1 more source

Mechanism of action of interleukin-1 in modulating gonadotropin secretion. In vivo and in vitro studies [PDF]

, 1998
To obtain further information on the mode of action of interleukin (IL)-1 in modulating gonadotropin secretion, a series of in vivo and in vitro studies has been performed with the beta-isoform of IL-1. IL-1 beta injected in a lateral ventricle of 3-week-
F. Piva, P. Limonta, D. Dondi, M. Montagnani Marelli   +3 more
core   +1 more source

Inference About Separable Causal Effects With Longitudinal Bivariate Ordinal Responses With Missingness and Censoring

Statistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT Causal inference has gained extensive attention in various fields, including healthcare, epidemiology, and social sciences. While many methods have been developed, most research has been directed to handle data with a univariate response variable.
Pingbo Hu, Grace Y. Yi
wiley   +1 more source

Phase I study of ZEN-008 (AN-152), a targeted cytotoxic LHRH analog, in female patients with cancers expressing LHRH receptors [PDF]

, 2006
13146 Background: Human ovarian, endometrial, and breast cancers commonly express receptors for luteinizing hormone releasing hormone (LHRH-R). LHRH-R can be used for targeted chemotherapy with ZEN-008 (AN-152), in which doxorubicin is linked to [D-Lys(6)
Emons, G, Gründker, C, Hamid-Werner, M, Günthert, A. R, Schally, A. V, Kaufmann, M, Loibl, S   +6 more
core   +1 more source

Receptor mediated antiproliferative effects of the cytotoxic LHRH agonist AN-152 in human ovarian and endometrial cancer cell lines [PDF]

, 2000
Eighty percent of human ovarian and endometrial cancers express receptors for luteinizing hormone-releasing hormone (LHRH). These receptors might be used for targeted chemotherapy with cytotoxic LHRH analogs such as AN-152, in which doxorubicin is linked
Schulz, Klaus-Dieter, Werning, G., Emons, G., Westphalen, S., Krauss, W., Schally, Andrew V., Kotulla, G., Elsasser, H. P., Grundker, Carsten, Kaiser, Armin Florian, Nagy, A.   +10 more
core   +2 more sources

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Sites of paradoxical action of the LHRH agonist (D-Trp6)-LHRH. [PDF]

, 1980
Immature intact and hypophysectomized female rats, which were primed with gonadotropin, were injected subcutaneously with 0.9% saline or 0.2 or 2 microgram of (D-Trp6)-LHRH once daily for 7 days.
Schally, Andrew V., Serafini, Paulo C., S, Talbot, A, Arimura   +3 more
core