Results 21 to 30 of about 2,558,356 (334)

Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans

Circulation, 2017
Background: Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB).
G. Reyes-Soffer, M. Pavlyha, C. Ngai, T. Thomas, S. Holleran, R. Ramakrishnan, W. Karmally, R. Nandakumar, Nelson Fontanez, Joseph Obunike, S. Marcovina, A. Lichtenstein, N. Matthan, James Matta, M. Maroccia, Frederic Becue, F. Poitiers, B. Swanson, L. Cowan, W. Sasiela, H. Surks, H. Ginsberg   +21 more
semanticscholar   +1 more source

Mechanics of cell integration in vivo [PDF]

arXiv, 2021
During embryonic development, regeneration and homeostasis, cells have to physically integrate into their target tissues, where they ultimately execute their function. Despite a significant body of research on how mechanical forces instruct cellular behaviors within the plane of an epithelium, very little is known about the mechanical interplay at the ...
arxiv  

LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer’s disease

Frontiers in Physiology, 2012
Low density lipoprotein receptor-related protein (LRP) belongs to the low-density lipoprotein receptor family, generally recognized as cell surface endocytic receptors, which bind and internalize extracellular ligands for degradation in lysosomes ...
Carlos eSpuch, Saida eOrtolano, Carmen eNavarro   +2 more
doaj   +1 more source

Lipoprotein receptors – an evolutionarily ancient multifunctional receptor family

Biological chemistry, 2010
The evolutionarily ancient low-density lipoprotein (LDL) receptor gene family represents a class of widely expressed cell surface receptors. Since the dawn of the first primitive multicellular organisms, several structurally and functionally distinct ...
Marco Dieckmann, M. Dietrich, J. Herz
semanticscholar   +1 more source

Lipopolysaccharide enters the rat brain by a lipoprotein-mediated transport mechanism in physiological conditions

Scientific Reports, 2017
Physiologically, lipopolysaccharide (LPS) is present in the bloodstream and can be bound to several proteins for its transport (i.e.) LPS binding protein (LBP) and plasma lipoproteins).
Alejandra Vargas-Caraveo, A. Sayd, Sandra R. Maus, J. Caso, J. Madrigal, B. García-Bueno, J. Leza   +6 more
semanticscholar   +1 more source

Mechanism of action of fibrates on lipid and lipoprotein metabolism.

Circulation, 1998
Treatment with fibrates, a widely used class of lipid-modifying agents, results in a substantial decrease in plasma triglycerides and is usually associated with a moderate decrease in LDL cholesterol and an increase in HDL cholesterol concentrations ...
B. Staels, J. Dallongeville, J. Auwerx, K. Schoonjans, E. Leitersdorf, J. Fruchart   +5 more
semanticscholar   +1 more source

LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages. [PDF]

PLoS ONE, 2015
Within the circulation, cholesterol is transported by lipoprotein particles and is taken up by cells when these particles associate with cellular receptors.
Anna P Lillis, Selen Catania Muratoglu, Dianaly T Au, Mary Migliorini, Mi-Jeong Lee, Susan K Fried, Irina Mikhailenko, Dudley K Strickland   +7 more
doaj   +1 more source

Large number of receptors may reduce cellular response time variation [PDF]

Physical biology 10 (3), 035008, 2013, 2012
Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv   +1 more source

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors.

Journal of Clinical Investigation, 2016
Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma triglycerides (TGs) correlate strongly with plasma apolipoprotein C-III (ApoC-III) levels.
P. Gordts, Ryan Nock, Ni-Huiping Son, B. Ramms, Irene Lew, J. Gonzales, Bryan E. Thacker, Debapriya Basu, Richard G. Lee, A. Mullick, M. Graham, I. Goldberg, R. Crooke, J. Witztum, J. Esko   +14 more
semanticscholar   +1 more source

Causal Models with Constraints [PDF]

arXiv, 2023
Causal models have proven extremely useful in offering formal representations of causal relationships between a set of variables. Yet in many situations, there are non-causal relationships among variables. For example, we may want variables $LDL$, $HDL$, and $TOT$ that represent the level of low-density lipoprotein cholesterol, the level of lipoprotein
arxiv