Results 291 to 300 of about 2,667,642 (350)

Lipoprotein receptors and atherosclerosis

Clinical Science, 1986
Mammalian cholesterol metabolism is governed by two key features of the steroid nucleus: it is poorly soluble in plasma and it cannot be degraded in animal tissues. Cells which require the lipid import it through their cytoplasmic membranes in the form of solubilized lipid-protein complexes, and a similar export mechanism is essential in order to ...
Christopher J. Packard, James Shepherd
openaire   +3 more sources

Macrophage lipoprotein receptors

Journal of Cell Science, 1988
ABSTRACT Macrophages possess a number of surface receptors that are capable of mediating the internalization of lipoproteins. The low-density lipoprotein (LDL) receptor of human monocyte macrophages recognizes apolipoprotein B-100 and apolipoprotein E and is rapidly regulated in response to changes in intracellular cholesterol levels. In
Margaret E. Haberland, Alan M. Fogelman, Peter A. Edwards, Craig H Warden, Brian J. Van Lenten   +4 more
openaire   +3 more sources

Regulation of plasma cholesterol by lipoprotein receptors.

Science, 1981
The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man.
Michael S. Brown, P. Kovanen, J. Goldstein   +2 more
semanticscholar   +1 more source

Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism

Hepatology, 1988
Hepatocytes, as the major site of synthesis and terminal catabolism of plasma lipoproteins, exert the major regulatory influence on the concentration of atherogenic lipoproteins in blood plasma and may thereby influence the rate of atherogenesis. The LDL receptor on the microvillous sinusoidal surface of hepatocytes mediates the catabolism of remnants ...
J M D Richard Havel, Robert L. Hamilton
openaire   +3 more sources

Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.

Annual Review of Biochemistry, 1983
PERSPECTIVES AND SUMMARY ............................... .... ....................................... 224 UPTAKE OF LIPOPROTEIN-BOUND CHOLESTEROL BY MACROPHAGES ..............................................................................................
M. Brown, J. Goldstein
semanticscholar   +1 more source

Lipoprotein-receptor interactions

1986
Publisher Summary This chapter focuses on the lipoprotein–receptor interactions. Lipoprotein receptors function as a major control mechanism for the regulation of lipoprotein catabolism. The classical studies of Goldstein and Brown demonstrated the importance of low-density lipoprotein (LDL) receptors in supplying cells with cholesterol and in ...
Robert W. Mahley, Robert E. Pitas, Thomas L. Innerarity   +2 more
openaire   +3 more sources

The Lipoprotein Receptor Concept

Drugs, 1988
The interaction of plasma lipoproteins with mammalian cells is facilitated by specific receptors on the cell surface. The chylomicron remnant receptor recognises apolipoprotein E (apo E) and mediates the uptake of chylomicron remnants by the liver. The low density lipoprotein (LDL) receptor recognises lipoproteins containing apolipoprotein B100 or an ...
openaire   +2 more sources

Lipoprotein receptors in perspective

Current Opinion in Lipidology, 1992
Recent findings regarding mutant founder genes, structure/function relationships and regulation of the LDL receptor are reviewed. New aspects regarding the control of the LDL receptor-related protein are presented. The structure and function of the scavenger receptor and the physiological role of the HDL receptor are considered.
Deneys R. van der Westhuyzen, Gerhard A. Coetzee   +1 more
openaire   +2 more sources

Role of bile acids and bile acid receptors in metabolic regulation.

Physiological Reviews, 2009
The incidence of the metabolic syndrome has taken epidemic proportions in the past decades, contributing to an increased risk of cardiovascular disease and diabetes.
P. Lefebvre, B. Cariou, F. Lien, F. Kuipers, B. Staels   +4 more
semanticscholar   +1 more source

Cellular signalling by lipoprotein receptors

Current Opinion in Lipidology, 2000
Lipoprotein receptors are commonly thought merely to mediate the internalization of lipoprotein particles or the exchange of lipids at the cell surface. Recent findings have now implicated these multifunctional receptors in cellular signalling mechanisms that extend beyond simple ligand endocytosis.
Michael Gotthardt, Thomas E. Willnow, Joachim Herz   +2 more
openaire   +3 more sources